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"title": "Heat-attributable mortality in Spain rose 15% per 1 °C of mean heatwave daily Tmax",
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"source": "Environment International, 22 October 2026",
"paper_title": "Mortality during heatwaves in Spain, 2015-2025: heat metrics, patterns and future risks",
"authors": "García-García D, León-Gómez I, Pérez-Marín L, Gómez-Barroso D",
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"title": "Amyloid and tau stage in 2711 Sao Paulo autopsies, by age and cognitive status",
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"source": "medRxiv, 22 October 2026",
"paper_title": "Amyloid and Tau Neuropathologic Stage, Coexisting Brain Disease, and Cognitive Status in a Population-Based Autopsy Cohort",
"authors": "Pereira FL, Leite REP, Paes V, Silva CM, Ururahy RR, Moraes FOC et al.",
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"title": "HPV catch-up vaccination to age 30 modelled in 132 low- and middle-income countries",
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"source": "medRxiv, 20 October 2026",
"paper_title": "Determining context-specific economically feasible age ranges for female HPV catch-up vaccination in LMICs: a model-based health economic assessment",
"authors": "Man I, Wondimu A, Georges D, Wittenauer R, Macacu A, Fuady A et al.",
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"source": "European Journal of Preventive Cardiology, 19 October 2026",
"paper_title": "Temperature-Attributable Cardiovascular Mortality in Europe Under Future Climate Scenarios: Projected Impacts of Population Aging and Climate Change to 2080",
"authors": "Parameswaran G, Ponnana SR, Sirasapalli SK, Presswalla F, Surya N, Zhang T et al.",
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"title": "Anti-obesity drugs in routine care: short exposure, smaller weight loss than in trials",
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"source": "BMC Endocrine Disorders, 20 October 2026",
"paper_title": "Current status of anti-obesity medications and performance, an EHR based survey",
"authors": "Ruan X, Li R, Wang L, Lu S, Wen A, Sameer M et al.",
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"title": "Scottish cohort of 3.7 million adults links disability and household setting to COVID-19",
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"url": "https://www.coios.me/scottish-cohort-of-3-7-million-adults-links-disability-and/",
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"source_url": "https://doi.org/10.23889/ijpds.v11i1.3417",
"source": "International Journal of Population Data Science, 22 October 2026",
"paper_title": "Cohort Profile: Disability, Household Living Arrangements and COVID-19 Outcomes in a Linked Population-Based Cohort of Scottish Adults",
"authors": "Adebisi YA, Henderson A, Bailey N, Dibben C, Pattaro S",
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"kind": "item",
"title": "Perioperative enfortumab vedotin and pembrolizumab in cisplatin-ineligible bladder cancer",
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"url": "https://www.coios.me/perioperative-enfortumab-vedotin-and-pembrolizumab-in/",
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"source_url": "https://doi.org/10.1001/jamanetworkopen.2026.40370",
"source": "JAMA Network Open, 20 October 2026",
"paper_title": "Cost-Effectiveness of Perioperative Enfortumab Vedotin and Pembrolizumab for Bladder Cancer",
"authors": "Su ZT, Garman TS, Rivera Lopez CA, Talwar R, Chelluri R, Johnson BA et al.",
"doi": "10.1001/jamanetworkopen.2026.40370",
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"design": "Decision-analytic Markov cost-utility model, 10 000 simulated cisplatin-ineligible MIBC patients (baseline age 73), Medicare perspective, 10-year horizon, efficacy from KEYNOTE-905/EV-303 (median follow-up 25.6 months); analyses Oct 2025-Aug 2026",
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"title": "FAHR-Face, a face photograph foundation model, estimates biological age and survival",
"excerpt": "A face photograph model fine-tuned on 34,363 patients with cancer separated mortality risk between quartiles.",
"url": "https://www.coios.me/fahr-face-a-face-photograph-foundation-model-estimates/",
"published_at": "2026-10-23T13:12:51.000Z",
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"source_url": "https://doi.org/10.1016/j.landig.2026.101056",
"source": "The Lancet Digital Health, 19 October 2026",
"paper_title": "Foundation artificial intelligence models for health recognition by use of face photographs (FAHR-Face): a model development and validation study",
"authors": "Haugg F, Lee G, He J, Nürnberg L, Bontempi D, Bitterman DS et al.",
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"design": "Foundation model development and validation: pretraining on >40 million facial photographs, fine-tuning on ten public image datasets and 34,363 photographs of patients with cancer, tested in two independent cancer cohorts with multivariable Cox survival analysis",
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"kind": "item",
"title": "Semaglutide: 14.5% of US initiators start at high dose, with earlier discontinuation",
"excerpt": "Among US adults starting injectable semaglutide, high-dose initiation was associated with a 25% higher early discontinuation risk and lower 1-year persistence.",
"url": "https://www.coios.me/semaglutide-14-5-of-us-initiators-start-at-high-dose-with/",
"published_at": "2026-10-23T13:12:21.000Z",
"updated_at": "2026-10-23T16:58:21.000Z",
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"source_url": "https://doi.org/10.1111/dom.71448",
"source": "Diabetes, Obesity and Metabolism, 19 October 2026",
"paper_title": "Real-World Semaglutide Initiation Behaviours in the United States: Impact on Early Treatment Discontinuation and on 1-Year Persistence",
"authors": "Belalcazar LM, Gao D, Modi S, Meer A, Kuo YF",
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"design": "Retrospective cohort, MarketScan commercial claims 2018-2021, 48,658 US adults initiating injectable semaglutide; Kaplan-Meier and piecewise Cox models, 12-month follow-up",
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"title": "HPV-attributable fraction in oropharyngeal cancer rose in seven countries over a decade",
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"url": "https://www.coios.me/hpv-attributable-fraction-in-oropharyngeal-cancer-rose-in/",
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"de",
"it",
"pt",
"es",
"cn",
"jp"
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"source_url": "https://doi.org/10.1093/jnci/djag375",
"source": "JNCI: Journal of the National Cancer Institute, 19 October 2026",
"paper_title": "Time trends of human papillomavirus-attributable head and neck cancers: the BROADEN study",
"authors": "Waterboer T, Zhao F, Giuliano A, Pavón MÀ, Qiao Y, Mirghani H et al.",
"doi": "10.1093/jnci/djag375",
"type": "Peer-reviewed article",
"design": "Retrospective multicentre tissue-based study, 6043 head and neck cancer patients, 88 hospitals, seven countries, two periods (2008-2009 and 2018-2019), central HPV-DNA, E6*I mRNA and p16 testing",
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"title": "Housing for homeless Californians with opioid use disorder modelled at $31,083 per QALY",
"excerpt": "A lifetime microsimulation of 18,928 Californians experiencing homelessness with opioid use disorder gave $31,083 per quality-adjusted life-year from expanding housing access.",
"url": "https://www.coios.me/housing-for-homeless-californians-with-opioid-use-disorder/",
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"source_url": "https://doi.org/10.64898/2026.10.15.26365505",
"source": "medRxiv, 19 October 2026",
"paper_title": "Cost-Effectiveness of Expanding Housing Access for People Experiencing Homelessness and Opioid Use Disorder in California",
"authors": "Ling Y, Tsung S, Alarid-Escudero F, Goldhaber-Fiebert JD, Brandeau ML, Reitsma MB",
"doi": "10.64898/2026.10.15.26365505",
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"title": "Polygenic modification of statin benefit may arise from trial eligibility criteria",
"excerpt": "Simulations with no true interaction reproduced the reported pattern of greater lipid-lowering benefit at higher coronary artery disease polygenic risk.",
"url": "https://www.coios.me/polygenic-modification-of-statin-benefit-may-arise-from/",
"published_at": "2026-10-23T13:10:12.000Z",
"updated_at": "2026-10-23T16:59:13.000Z",
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"verdict": "contradicts",
"source_url": "https://doi.org/10.64898/2026.10.18.26365857",
"source": "medRxiv, 20 October 2026",
"paper_title": "Polygenic prediction of treatment response for precision medicine is vulnerable to collider bias",
"authors": "Tudball MJ, Cirulli ET, Holmes MV, Davey Smith G, Richards JB",
"doi": "10.64898/2026.10.18.26365857",
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"design": "Simulation study of collider bias from trial eligibility criteria plus observational replication in Helix Research Network (n=175,106) and UK Biobank (n=92,859)",
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"kind": "item",
"title": "NHSO-T2DM resource links six Thai routine-care files for 1,421,470 people with diabetes",
"excerpt": "Six Thai routine-care files were linked by encrypted identifier into registry, visit and drug exposure tables.",
"url": "https://www.coios.me/nhso-t2dm-resource-links-six-thai-routine-care-files-for-1/",
"published_at": "2026-10-23T13:10:01.000Z",
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"source_url": "https://doi.org/10.23889/ijpds.v8i6.3460",
"source": "International Journal of Population Data Science, 20 October 2026",
"paper_title": "Data Resource Profile: A National Linked Routine-Care Data Resource for Longitudinal Health Services Research in Thailand: The National Health Security Office–type 2 Diabetes Mellitus (NHSO–T2DM) Extract, 2017–2024",
"authors": "Pasookhush P, Surawit A, Sirirungreung A, Narindrarangkura P, Rangsin R, Suta S et al.",
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"kind": "item",
"title": "US childhood hepatitis B vaccine policy changes modelled to increase chronic infections",
"excerpt": "A Markov model of a 3.6 million US birth cohort projects 83% more childhood chronic hepatitis B infections under shared decision making.",
"url": "https://www.coios.me/us-childhood-hepatitis-b-vaccine-policy-changes-modelled-to/",
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"us"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.7326/annals-26-02135",
"source": "Annals of Internal Medicine, 20 October 2026",
"paper_title": "Projected Effect of 2026 Federal Changes to the Childhood Immunization Schedule on Chronic Hepatitis B Virus Infections in the United States",
"authors": "Mohareb AM, Ganapathi L, Dugdale CM, Rajbhandari R, Ciaranello A, Neilan AM et al.",
"doi": "10.7326/annals-26-02135",
"type": "Peer-reviewed article",
"design": "Markov cohort state-transition model of perinatal and childhood HBV infection, one US birth cohort (n=3.6 million), 20-year horizon, probabilistic sensitivity analysis",
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},
{
"kind": "item",
"title": "Long-term ozone and stroke risk in 20 757 Polish patients with atrial fibrillation",
"excerpt": "In Polish patients with atrial fibrillation, each interquartile rise in ozone was associated with a 27% higher composite stroke risk.",
"url": "https://www.coios.me/long-term-ozone-and-stroke-risk-in-20-757-polish-patients/",
"published_at": "2026-10-23T13:06:38.000Z",
"updated_at": "2026-10-24T06:06:04.000Z",
"domain": "Data, models and systems",
"drivers": [
"AI in medicine",
"Slowing ageing itself"
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"d-ai-medicine",
"d-ageing"
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"countries": [
"Poland"
],
"country_codes": [
"pl"
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.20452/pamw.17430",
"source": "Polish Archives of Internal Medicine, 20 October 2026",
"paper_title": "Long-term ozone exposure and adverse outcomes in atrial fibrillation: the population-based ARS-PARTICLES cohort",
"authors": "Wang C, Lip GYH, Jemielita P, Święczkowski M, Kurasz A, Zhao D et al.",
"doi": "10.20452/pamw.17430",
"type": "Peer-reviewed article",
"design": "Population-based cohort, 20,757 adults with prevalent atrial fibrillation in Podlaskie Voivodeship, 2014-2019 (median 5.6 years), GEM-AQ modelled pollutant exposure, Fine-Gray competing-risk models",
"coverage": "",
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},
{
"kind": "item",
"title": "Smoking status and survival across solid cancers in a Finnish two-hospital cohort",
"excerpt": "Five-year overall survival was 71% in never smokers, 58% in former smokers and 49% in current smokers.",
"url": "https://www.coios.me/smoking-status-and-survival-across-solid-cancers-in-a/",
"published_at": "2026-10-23T13:05:41.000Z",
"updated_at": "2026-10-24T06:06:03.000Z",
"domain": "Health today",
"drivers": [
"Cancer",
"Smoking and vaping",
"What linked data reveals"
],
"driver_slugs": [
"d-cancer",
"d-smoking-vaping",
"d-linked-data"
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"countries": [
"Finland"
],
"country_codes": [
"fi"
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1016/j.esmorw.2026.100791",
"source": "ESMO Real World Data and Digital Oncology, 22 October 2026",
"paper_title": "Smoking status and survival by cancer type and treatment intent in a population-based cohort with adjustment for major prognostic factors",
"authors": "Heervä E, Ellonen A, Kukkurainen S, Mikkola T, Savolainen K, Laitinen T et al.",
"doi": "10.1016/j.esmorw.2026.100791",
"type": "Peer-reviewed article",
"design": "Population-based retrospective cohort, two Finnish university hospitals, 62,893 solid-cancer patients diagnosed 2009-2019 (smoking status available for 45,395), NLP-extracted exposure linked to national mortality, Cox models adjusted for age, sex, performance status, comorbidity, nodal status and treatment intent",
"coverage": "",
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},
{
"kind": "item",
"title": "Lecanemab in real-world practice: pooled ARIA, discontinuation and cognitive outcomes",
"excerpt": "Any ARIA occurred in 15.1% of lecanemab-treated patients in real-world cohorts, rising to 34.1% in APOE e4 homozygotes.",
"url": "https://www.coios.me/lecanemab-in-real-world-practice-pooled-aria/",
"published_at": "2026-10-23T13:05:21.000Z",
"updated_at": "2026-10-23T17:02:21.000Z",
"domain": "Health today",
"drivers": [
"Dementia"
],
"driver_slugs": [
"d-dementia"
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"countries": [
"World"
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"country_codes": [
"world"
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1007/s00415-026-14224-y",
"source": "Journal of Neurology, 22 October 2026",
"paper_title": "Real-world safety and efficacy of lecanemab in the treatment of Alzheimer's disease: a systematic review and meta-analysis",
"authors": "Wu Y, Zhu L, Chen J, Liu J, Yin K, Yang X",
"doi": "10.1007/s00415-026-14224-y",
"type": "Peer-reviewed article",
"design": "Systematic review and random-effects meta-analysis of 37 real-world lecanemab studies, searched to October 2026, with subgroup and leave-one-out sensitivity analyses",
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"granularity": "",
"latency": "",
"access": "",
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},
{
"kind": "item",
"title": "Type 2 diabetes remission and relapse after metabolic-bariatric procedures in ARMMS-T2D",
"excerpt": "In ARMMS-T2D, 58% assigned to metabolic-bariatric procedures reached diabetes remission over a median 11 years, against 3% on medical-lifestyle care.",
"url": "https://www.coios.me/type-2-diabetes-remission-and-relapse-after-metabolic/",
"published_at": "2026-10-23T13:05:13.000Z",
"updated_at": "2026-10-23T17:02:13.000Z",
"domain": "Health today",
"drivers": [
"Obesity, diabetes and GLP-1"
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"d-obesity-diabetes"
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"countries": [
"United States"
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"country_codes": [
"us"
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.2337/dc26-1070",
"source": "Diabetes Care, 20 October 2026",
"paper_title": "Predictors of Type 2 Diabetes Remission and Relapse After Metabolic-Bariatric Surgery or Medical-Lifestyle Therapy in the ARMMS-T2D Study",
"authors": "Simonson DC, Cummings DE, Schauer PR, Aminian A, Hu B, Arterburn DE et al.",
"doi": "10.2337/dc26-1070",
"type": "Peer-reviewed article",
"design": "Secondary analysis of pooled randomised trials (ARMMS-T2D), n=262 (166 surgery, 96 medical-lifestyle), median 11 years' follow-up, maximum 14 years; univariate time-to-event plus LASSO multivariate predictor modelling",
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"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
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"size": "",
"reason": "",
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"attention": "",
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"corrected": ""
},
{
"kind": "item",
"title": "Plant-based diet indices and frailty in 8,628 older adults across three ageing cohorts",
"excerpt": "Higher overall plant-based scores were associated with lower frailty risk (ORs 0.71-0.80), unhealthful scores with higher risk (1.24-1.41).",
"url": "https://www.coios.me/plant-based-diet-indices-and-frailty-in-8-628-older-adults/",
"published_at": "2026-10-23T13:05:03.000Z",
"updated_at": "2026-10-23T17:02:04.000Z",
"domain": "Health today",
"drivers": [
"Frailty and multimorbidity",
"Diet, exercise and sleep",
"Slowing ageing itself"
],
"driver_slugs": [
"d-frailty-multimorbidity",
"d-diet-activity",
"d-ageing"
],
"countries": [
"China",
"United States",
"United Kingdom",
"European Union"
],
"country_codes": [
"cn",
"us",
"gb",
"eu"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1093/ageing/afag304",
"source": "Age and Ageing, 21 October 2026",
"paper_title": "Plant-based dietary patterns and frailty in older adults: a multicohort longitudinal study with within-between decomposition and network analysis",
"authors": "Lin J, Zhang J, Hu B, Geng L",
"doi": "10.1093/ageing/afag304",
"type": "Peer-reviewed article",
"design": "Multicohort longitudinal observational analysis, 8,628 older adults in CLHLS, HRS and ELSA plus 10,821 in SHARE; generalised linear mixed models with within-between (Mundlak) decomposition, spline and network analysis",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
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},
{
"kind": "item",
"title": "Behavioural health ED patients leaving unseen return, are admitted and die more often",
"excerpt": "Among 1,305,812 US emergency department behavioural health episodes, a 7-day return visit followed 24.5% of those leaving without being seen, against 13.2% after completed care.",
"url": "https://www.coios.me/behavioural-health-ed-patients-leaving-unseen-return-are/",
"published_at": "2026-10-23T13:02:30.000Z",
"updated_at": "2026-10-23T17:03:30.000Z",
"domain": "Data, models and systems",
"drivers": [
"Health systems and access"
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"d-health-systems"
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"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.10.14.26365554",
"source": "medRxiv, 20 October 2026",
"paper_title": "Return Visits, Admission, and Mortality After Leaving Without Being Seen Among Emergency Department Patients With Behavioral Health Presentations",
"authors": "Ashoo S, Peacock WF, Colovos C, Durieux J",
"doi": "10.64898/2026.10.14.26365554",
"type": "Preprint",
"design": "Retrospective episode-level cohort in a multisystem deidentified US EHR database; 1,305,812 ED episodes (12,248 LWBS) from 525,490 patients, index visits 2001-2025, mortality assessed 2017-2023",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
"vintages": "",
"size": "",
"reason": "",
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},
{
"kind": "item",
"title": "Hypertension prevalence in Japan projected to 2040 using a Bayesian Lee-Carter model",
"excerpt": "Crude hypertension prevalence in Japan is projected to stay near 47% in men to 2040; untreated or uncontrolled cases fall.",
"url": "https://www.coios.me/hypertension-prevalence-in-japan-projected-to-2040-using-a/",
"published_at": "2026-10-23T13:00:04.000Z",
"updated_at": "2026-10-24T06:06:04.000Z",
"domain": "Data, models and systems",
"drivers": [
"Forecasts and their record",
"Heart and stroke"
],
"driver_slugs": [
"d-forecasting",
"d-cardiovascular"
],
"countries": [
"Japan"
],
"country_codes": [
"jp"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1038/s41440-026-02814-2",
"source": "Hypertension Research, 19 October 2026",
"paper_title": "Projected prevalence of hypertension and untreated/uncontrolled hypertension in Japan through 2040",
"authors": "Yoshikawa Y, Ogata S, Mondal R, Yano Y, Arima H, Kypridemos C et al.",
"doi": "10.1038/s41440-026-02814-2",
"type": "Peer-reviewed article",
"design": "Projection study using National Health and Nutrition Survey prevalence 1986-2019 with three models (Bayesian Lee-Carter, monotonic, constant) applied to national population projections through 2040",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
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"vintages": "",
"size": "",
"reason": "",
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},
{
"kind": "item",
"title": "E-cigarette flavour use and later vaping abstinence in US youth and adults, PATH 2016-2023",
"excerpt": "Exclusive tobacco or flavourless vaping preceded higher odds of 30-day e-cigarette abstinence, while use of multiple flavours preceded lower odds.",
"url": "https://www.coios.me/e-cigarette-flavour-use-and-later-vaping-abstinence-in-us/",
"published_at": "2026-10-23T12:58:30.000Z",
"updated_at": "2026-10-23T17:04:30.000Z",
"domain": "Behavioural science",
"drivers": [
"Smoking and vaping"
],
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"d-smoking-vaping"
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"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1111/add.70674",
"source": "Addiction, 20 October 2026",
"paper_title": "Flavored e-cigarette use and its association with subsequent short-term e-cigarette abstinence among youth, young adults and adults: Findings from the United States longitudinal population assessment of tobacco use and health, 2016 to 2023",
"authors": "Streck JM, Hyatt AS, Schuster RM, Gilman J, Levy S, Winickoff JP et al.",
"doi": "10.1111/add.70674",
"type": "Peer-reviewed article",
"design": "Prospective observational analysis of PATH waves 4-7 (2016-2023), n=8418 US youth and adults, lagged wave-pair GEE models, weighted",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
"vintages": "",
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"reason": "",
"supersedes": "",
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},
{
"kind": "item",
"title": "Frailty at 50 linked to shorter healthy working life expectancy across 33 countries",
"excerpt": "In 180,314 adults from five harmonised ageing cohorts, healthy working life expectancy at age 50 was 11.87 years for robust participants, 7.34 years for pre-frail and 3.77 years for frail.",
"url": "https://www.coios.me/frailty-at-50-linked-to-shorter-healthy-working-life/",
"published_at": "2026-10-23T12:55:06.000Z",
"updated_at": "2026-10-24T06:06:05.000Z",
"domain": "Health today",
"drivers": [
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"What linked data reveals"
],
"driver_slugs": [
"d-frailty-multimorbidity",
"d-linked-data"
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"countries": [
"World"
],
"country_codes": [
"world"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.7189/jogh.16.04338",
"source": "Journal of Global Health, 19 October 2026",
"paper_title": "Frailty and healthy working life expectancy: a multicohort modelling study",
"authors": "Shui Y, Zhu J, Huang Z, You H, Gao J",
"doi": "10.7189/jogh.16.04338",
"type": "Peer-reviewed article",
"design": "Multistate discrete-time Markov modelling of five harmonised ageing cohorts, 180,314 participants aged 50+ across 33 countries",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
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"reason": "",
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},
{
"kind": "item",
"title": "GLP-1 receptor agonists do not improve cognition or function in Alzheimer's disease or MCI",
"excerpt": "GLP-1 receptor agonists improved neither cognition nor disease progression in pooled trials, with more adverse events and discontinuation.",
"url": "https://www.coios.me/glp-1-receptor-agonists-do-not-improve-cognition-or/",
"published_at": "2026-10-19T11:59:22.000Z",
"updated_at": "2026-10-20T06:05:53.000Z",
"domain": "Health today",
"drivers": [
"Obesity, diabetes and GLP-1",
"Dementia"
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"driver_slugs": [
"d-obesity-diabetes",
"d-dementia"
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"countries": [
"World"
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"country_codes": [
"world"
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1002/trc2.70334",
"source": "Alzheimer's & Dementia: Translational Research & Clinical Interventions, 17 October 2026",
"paper_title": "GLP‐1 receptor agonists in Alzheimer's disease and MCI: a meta‐analysis",
"authors": "Siqueira RGP, Ranalli C, Yılmaz D, da Silva M, Maltez BRP, Berton GG et al.",
"doi": "10.1002/trc2.70334",
"type": "Peer-reviewed article",
"design": "Systematic review and meta-analysis of 7 randomised controlled trials, 4132 participants, mean age 72.1, searched to April 2026",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
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},
{
"kind": "item",
"title": "Depression recorded after cancer diagnosis and suicide risk in 755,079 South Korean adults",
"excerpt": "Cancer patients with no prior depression who were later diagnosed with it had a suicide hazard 4.76 times that of those without.",
"url": "https://www.coios.me/depression-recorded-after-cancer-diagnosis-and-suicide-risk/",
"published_at": "2026-10-19T11:59:12.000Z",
"updated_at": "2026-10-19T12:34:14.000Z",
"domain": "Health today",
"drivers": [
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"Mental health"
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"driver_slugs": [
"d-cancer",
"d-mental-health"
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"countries": [
"South Korea"
],
"country_codes": [
"kr"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1002/pon.70635",
"source": "Psycho-Oncology, 18 October 2026",
"paper_title": "Post‐Diagnosis Depression and Suicide Risk Among Cancer Survivors: A Nationwide Population‐Based Cohort Study",
"authors": "Lee S, Kim S",
"doi": "10.1002/pon.70635",
"type": "Peer-reviewed article",
"design": "Nationwide registry cohort, 755,079 adults with incident cancer 2009-2013 followed to 2023 (median 13.0 years, 1926 suicides), time-dependent Cox and Fine-Gray models",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
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"reason": "",
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},
{
"kind": "item",
"title": "Bacteraemia resistance and strain trends in Calgary alongside antibiotic prescribing",
"excerpt": "Population-based Calgary cohort covering five bacteraemia pathogens, 2006 to 2022: fluoroquinolone resistance fell in Gram-positive species, while Escherichia coli ST1193 and CTX-M-27-producing ST131 rose.",
"url": "https://www.coios.me/bacteraemia-resistance-and-strain-trends-in-calgary/",
"published_at": "2026-10-19T11:56:32.000Z",
"updated_at": "2026-10-19T12:34:33.000Z",
"domain": "Behavioural science",
"drivers": [
"Infection and pandemics"
],
"driver_slugs": [
"d-infectious-disease"
],
"countries": [
"Canada"
],
"country_codes": [
"ca"
],
"source_type": "preprint",
"verdict": "refines",
"source_url": "https://doi.org/10.64898/2026.08.27.26361471",
"source": "medRxiv, 17 October 2026",
"paper_title": "Trends in incidence and antimicrobial resistance for five major causes of bacteraemia in a Canadian metropolitan area, 2006–22: a genomic and antimicrobial use cohort study",
"authors": "Pham TM, Smith JT, Mortimer TD, Grad YH, Earl AM, Lewis I",
"doi": "10.64898/2026.08.27.26361471",
"type": "Preprint",
"design": "Population-based cohort with whole-genome sequencing of 23,363 bacteraemia isolates (five species), Calgary Health Zone, 2006-2022, linked to antimicrobial prescribing rates; negative-binomial and binomial regression, AAPC trends",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
"vintages": "",
"size": "",
"reason": "",
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},
{
"kind": "item",
"title": "US obesity treatment access modelled as 5.3 million preventable deaths over a decade",
"excerpt": "Modelling projects 5.3 million preventable deaths and $10.5-13.3 trillion foregone benefits over a decade of restricted obesity treatment access.",
"url": "https://www.coios.me/us-obesity-treatment-access-modelled-as-5-3-million/",
"published_at": "2026-10-19T11:52:30.000Z",
"updated_at": "2026-10-20T06:05:52.000Z",
"domain": "Data, models and systems",
"drivers": [
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"Value in health",
"Obesity, diabetes and GLP-1"
],
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"d-health-economics",
"d-obesity-diabetes"
],
"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.2337/doci25-0011",
"source": "Diabetes Obesity and Cardiometabolic CARE, 17 October 2026",
"paper_title": "The Cost of Inaction in Treating Obesity in the U.S",
"authors": "Sapra T, Chen F, Dall TM, Hafida S, Moody A, Ferguson C et al.",
"doi": "10.2337/doci25-0011",
"type": "Peer-reviewed article",
"design": "Microsimulation of 107.6 million US adults with obesity, three access scenarios, 10-year horizon",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
"vintages": "",
"size": "",
"reason": "",
"supersedes": "",
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},
{
"kind": "item",
"title": "GLP-1 agonists and atrial fibrillation in non-diabetic obesity with kidney disease",
"excerpt": "GLP-1 users with obesity and CKD had 1.63% one-year incident atrial fibrillation, against 2.62% in unexposed patients.",
"url": "https://www.coios.me/glp-1-agonists-and-atrial-fibrillation-in-non-diabetic/",
"published_at": "2026-10-19T11:45:48.000Z",
"updated_at": "2026-10-19T12:37:48.000Z",
"domain": "Health today",
"drivers": [
"Obesity, diabetes and GLP-1",
"Heart and stroke"
],
"driver_slugs": [
"d-obesity-diabetes",
"d-cardiovascular"
],
"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1016/j.ijcard.2026.135000",
"source": "International Journal of Cardiology, 18 October 2026",
"paper_title": "GLP-1 receptor agonist therapy and incident atrial fibrillation in non-diabetic adults with obesity and chronic kidney disease: a propensity matched cohort study",
"authors": "Hassan A, Okorigba E, Grace C, Otabor E, Osineye B, Olayiwola O et al.",
"doi": "10.1016/j.ijcard.2026.135000",
"type": "Peer-reviewed article",
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{
"kind": "item",
"title": "Influenza antibody titres waned by strain, not uniformly, in Michigan and Hong Kong",
"excerpt": "H1N1 titres fell in Michigan and two H3N2 strains fell in Hong Kong; other strains changed little.",
"url": "https://www.coios.me/influenza-antibody-titres-waned-by-strain-not-uniformly-in/",
"published_at": "2026-10-19T11:39:57.000Z",
"updated_at": "2026-10-19T12:37:57.000Z",
"domain": "Behavioural science",
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"Infection and pandemics"
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"d-infectious-disease"
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"countries": [
"United States",
"Hong Kong"
],
"country_codes": [
"us",
"hk"
],
"source_type": "preprint",
"verdict": "refines",
"source_url": "https://doi.org/10.1101/2025.05.26.25328346",
"source": "medRxiv, 17 October 2026",
"paper_title": "A prospective, comparative cohort analysis of influenza antibody waning in Michigan and Hong Kong during periods of low influenza circulation",
"authors": "Yang Y, Smith M, Ho F, Truscon R, Leung NHL, Touyon L et al.",
"doi": "10.1101/2025.05.26.25328346",
"type": "Preprint",
"design": "Two prospective serological cohorts (HIVE Michigan, n=57, 173 sera; EPI-HK Hong Kong, n=60, 259 sera), 2020-2023, HAI and microneutralisation, power-law fold-change models",
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},
{
"kind": "item",
"title": "Moderate-to-vigorous activity and cardiovascular mortality in US adults with MASLD",
"excerpt": "Among 2785 adults with MASLD, 10 more minutes of moderate-to-vigorous activity gave a hazard ratio of 0.72 for cardiovascular death.",
"url": "https://www.coios.me/moderate-to-vigorous-activity-and-cardiovascular-mortality/",
"published_at": "2026-10-19T11:33:35.000Z",
"updated_at": "2026-10-19T12:38:35.000Z",
"domain": "Behavioural science",
"drivers": [
"Diet, exercise and sleep",
"Obesity, diabetes and GLP-1"
],
"driver_slugs": [
"d-diet-activity",
"d-obesity-diabetes"
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"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1111/jgh.70826",
"source": "Journal of Gastroenterology and Hepatology, 18 October 2026",
"paper_title": "Impact of Physical Activity on Cardiovascular Outcomes in Metabolic Dysfunction‐Associated Steatotic Liver Disease",
"authors": "Kim D, Danpanichkul P, Kim DH, Ko D, Wijarnpreecha K, Ahmed A",
"doi": "10.1111/jgh.70826",
"type": "Peer-reviewed article",
"design": "Prospective cohort analysis of NHANES 2003-2006 with accelerometry, n=2785 adults with HSI-defined MASLD, 584 deaths (198 cardiovascular), mortality linkage to December 2019, median follow-up 14.7 years",
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},
{
"kind": "item",
"title": "Enzalutamide in prostate cancer costs AUD$835,580 per QALY in ENZAMET trial analysis",
"excerpt": "Adding enzalutamide in the ENZAMET trial cost AUD$835,580 per QALY gained, far above the AUD$50,000 threshold.",
"url": "https://www.coios.me/enzalutamide-in-prostate-cancer-costs-aud-835-580-per-qaly/",
"published_at": "2026-10-18T11:36:59.000Z",
"updated_at": "2026-10-19T06:05:51.000Z",
"domain": "Data, models and systems",
"drivers": [
"Value in health",
"Cancer",
"Innovation in treatment"
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"driver_slugs": [
"d-health-economics",
"d-cancer",
"d-treatment-innovation"
],
"countries": [
"Australia"
],
"country_codes": [
"au"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1016/j.eclinm.2026.104207",
"source": "eClinicalMedicine, 17 October 2026",
"paper_title": "Cost-effectiveness of adding enzalutamide vs standard non-steroidal antiandrogen drugs for patients with metastatic hormone-sensitive prostate cancer undergoing standard first-line therapy: a within-trial, secondary end-point analysis of the ENZAMET phase 3, international randomized trial (ANZUP 1304)",
"authors": "Law CK, Stockler MR, Martin AJ, Davis ID, Sweeney CJ, Morton RL",
"doi": "10.1016/j.eclinm.2026.104207",
"type": "Peer-reviewed article",
"design": "Within-trial cost-effectiveness/cost-utility analysis of the ENZAMET open-label phase 3 RCT (ANZUP 1304), Australian health system perspective, trial records linked to Medicare claims and EQ-5D-5L questionnaires, 68-month median follow-up, data cut-off January 2022, costs in 2023 AUD",
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},
{
"kind": "item",
"title": "Social needs Z59 codes and subsequent acute care across 21 US health systems",
"excerpt": "Emergency visits were 67% higher after a first Z59 hardship code, but an administrative code reproduced much of this.",
"url": "https://www.coios.me/social-needs-z59-codes-and-subsequent-acute-care-across-21/",
"published_at": "2026-10-18T11:34:13.000Z",
"updated_at": "2026-10-18T12:15:57.000Z",
"domain": "Data, models and systems",
"drivers": [
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"AI in medicine",
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"d-ai-medicine",
"d-health-systems"
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"countries": [
"United States"
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"us"
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"source_type": "preprint",
"verdict": "refines",
"source_url": "https://doi.org/10.64898/2026.10.14.26365559",
"source": "medRxiv, 16 October 2026",
"paper_title": "Social Needs Z Codes and Subsequent Acute Care Across 21 U.S. Health Systems",
"authors": "Lobelo F, Durieux J, Ashoo S, Colovos C",
"doi": "10.64898/2026.10.14.26365559",
"type": "Preprint",
"design": "Matched cohort in linked EHR-claims data, 4.95m patients across 21 US health systems, 26,153 adults with a first outpatient Z59 code, with an administrative-code negative control; one year of follow-up",
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"granularity": "",
"latency": "",
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},
{
"kind": "item",
"title": "Type 2 diabetes remission is uncommon, brief and usually ended by a treatment restart",
"excerpt": "Recorded remission reached 3.82% at five years in treated adults, and ended more often by treatment restart than rising HbA1c.",
"url": "https://www.coios.me/type-2-diabetes-remission-is-uncommon-brief-and-usually/",
"published_at": "2026-10-18T11:24:23.000Z",
"updated_at": "2026-10-18T12:15:58.000Z",
"domain": "Health today",
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"Obesity, diabetes and GLP-1",
"What linked data reveals"
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"countries": [
"United States"
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"country_codes": [
"us"
],
"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.10.14.26365480",
"source": "medRxiv, 16 October 2026",
"paper_title": "Remission of Type 2 Diabetes in Linked Health Records: Uncommon, Short-Lived, and More Often Ended by Treatment Restart Than by Rising HbA1c",
"authors": "Lobelo F, Durieux J, Kim DS, Colovos C",
"doi": "10.64898/2026.10.14.26365480",
"type": "Preprint",
"design": "Retrospective cohort in linked EHR-claims data; 136,781 adults with laboratory-confirmed type 2 diabetes (96,817 previously treated, 39,964 untreated at entry), Aalen-Johansen competing-risk follow-up to 5 years",
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"granularity": "",
"latency": "",
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},
{
"kind": "item",
"title": "Temperature-related mortality across 3,116 Dutch districts is dominated by cold, not heat",
"excerpt": "Cold was associated with 11,988 excess deaths a year in the Netherlands, heat with 346.",
"url": "https://www.coios.me/temperature-related-mortality-across-3-116-dutch-districts/",
"published_at": "2026-10-18T11:24:04.000Z",
"updated_at": "2026-10-19T06:05:53.000Z",
"domain": "Tomorrow's world",
"drivers": [
"A changing climate"
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"driver_slugs": [
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"countries": [
"Netherlands"
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"country_codes": [
"nl"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1097/EE9.0000000000000534",
"source": "Environmental Epidemiology, 17 October 2026",
"paper_title": "District-level analysis of temperature-related excess mortality in the Netherlands",
"authors": "Ndiaye A, Daanen H, van de Kassteele J, de Hoogh K, Zwakhals L, van Asten L et al.",
"doi": "10.1097/EE9.0000000000000534",
"type": "Peer-reviewed article",
"design": "Three-stage small-area attribution: case time series with distributed lag nonlinear models across 355 municipalities, multivariate meta-regression pooling, downscaled to 3,116 districts, two age groups, 2010-2019",
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},
{
"kind": "item",
"title": "Parkinson's disease mortality in the US was flat from 1999 to 2025",
"excerpt": "Age-adjusted Parkinson's mortality was flat across 1999-2025; the post-2021 fall largely reflects the unwinding of COVID-19 co-listing.",
"url": "https://www.coios.me/parkinson-s-disease-mortality-in-the-us-was-flat-from-1999/",
"published_at": "2026-10-18T11:22:16.000Z",
"updated_at": "2026-10-19T06:05:51.000Z",
"domain": "Data, models and systems",
"drivers": [
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"Revisions and new sources"
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"d-data-sources"
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"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.3389/fneur.2026.1934146",
"source": "Frontiers in Neurology, 17 October 2026",
"paper_title": "Parkinson’s disease mortality in the United States, 1999–2025: a national multiple-cause-of-death analysis with projections to 2030",
"authors": "Atif E, Das V, Ali M, Ahmad A, Fatima K, Hassan MA et al.",
"doi": "10.3389/fneur.2026.1934146",
"type": "Peer-reviewed article",
"design": "Serial cross-sectional analysis of CDC WONDER multiple-cause-of-death files, 1,149,731 Parkinson's-related deaths in adults aged 45+, 1999-2025, with joinpoint regression and back-tested ensemble projection to 2030",
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},
{
"kind": "item",
"title": "Drought-attributable excess mortality in Somalia, 2015-2024: a small-area modelling study",
"excerpt": "Modelling estimated 71,100 excess deaths in Somalia during the 2022-2024 drought, 91% of them children under 5.",
"url": "https://www.coios.me/drought-attributable-excess-mortality-in-somalia-2015-2024/",
"published_at": "2026-10-18T11:15:28.000Z",
"updated_at": "2026-10-19T06:05:52.000Z",
"domain": "Tomorrow's world",
"drivers": [
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"Revisions and new sources"
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"d-data-sources"
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"countries": [
"Somalia"
],
"country_codes": [
"so"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1016/j.lanafr.2026.100072",
"source": "The Lancet Regional Health - Africa, 17 October 2026",
"paper_title": "Drought-attributable mortality in Somalia, 2015–2024: a retrospective and modelling study",
"authors": "Ouchtar Y, Ali DA, Ahmed YA, Adam MH, Dirie NI, Warsame A et al.",
"doi": "10.1016/j.lanafr.2026.100072",
"type": "Peer-reviewed article",
"design": "Retrospective small-area modelling of excess mortality, Somalia 2015-2024, district-month resolution, from reanalysed household mortality surveys with reconstructed census/displacement denominators and two counterfactual scenarios",
"coverage": "",
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},
{
"kind": "item",
"title": "Smaller colorectal tumours linked to nodal metastasis risk and worse survival in subgroups",
"excerpt": "In 10,513 colorectal cancer patients, smaller tumour diameter raised predicted lymph node metastasis risk and, below 3 cm, mortality.",
"url": "https://www.coios.me/smaller-colorectal-tumours-linked-to-nodal-metastasis-risk/",
"published_at": "2026-10-18T11:08:05.000Z",
"updated_at": "2026-10-19T06:05:52.000Z",
"domain": "Health today",
"drivers": [
"Cancer",
"AI in medicine"
],
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"d-cancer",
"d-ai-medicine"
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"countries": [
"China"
],
"country_codes": [
"cn"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.3389/fonc.2026.1908104",
"source": "Frontiers in Oncology, 17 October 2026",
"paper_title": "New insights into tumor size in colorectal cancer: smaller size, higher risk?",
"authors": "Ding R, Li T, Li C, Song W, Gao X, Xu M et al.",
"doi": "10.3389/fonc.2026.1908104",
"type": "Peer-reviewed article",
"design": "Retrospective two-centre cohort, 10,513 resected colorectal cancer patients (Shanghai, 2008-2020) with external validation in 6,739; machine-learning risk models plus Cox/spline survival analysis",
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},
{
"kind": "item",
"title": "Primary care death records match ONS registrations for 88% of deaths in OpenSAFELY-TPP",
"excerpt": "Of 1,409,275 ONS-registered deaths from 2020 to 2025, 88% had the same date of death in primary care and 8% had none.",
"url": "https://www.coios.me/primary-care-death-records-match-ons-registrations-for-88/",
"published_at": "2026-10-17T09:20:00.000Z",
"updated_at": "2026-10-18T12:15:59.000Z",
"domain": "Data, models and systems",
"drivers": [
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"countries": [
"United Kingdom"
],
"country_codes": [
"gb"
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"source_type": "preprint",
"verdict": "refines",
"source_url": "https://doi.org/10.64898/2026.10.14.26365028",
"source": "medRxiv, 15 October 2026",
"paper_title": "Accuracy and completeness of death recording in primary care electronic health records compared with national death registrations in England using OpenSAFELY-TPP",
"authors": "Pesce M, Hulme WJ, Kyomuhangi I, Prestige E, Evans D, Wong SY et al.",
"doi": "10.64898/2026.10.14.26365028",
"type": "Preprint",
"design": "Validation of linked primary care EHR death records against national death registrations, OpenSAFELY-TPP, 1,409,275 ONS-registered deaths, 2020-2025",
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{
"kind": "item",
"title": "Wildfire smoke PM2.5 in US counties: excess deaths peak three years after exposure",
"excerpt": "Monthly county-level wildfire PM2.5 and mortality data gave 1.7 million smoke-associated deaths over 2011-2023, about ten times conventional estimates.",
"url": "https://www.coios.me/wildfire-smoke-pm2-5-in-us-counties-excess-deaths-peak/",
"published_at": "2026-10-17T09:19:33.000Z",
"updated_at": "2026-10-18T12:15:59.000Z",
"domain": "Tomorrow's world",
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"countries": [
"United States"
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"country_codes": [
"us"
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"source_type": "preprint",
"verdict": "contradicts",
"source_url": "https://doi.org/10.64898/2026.10.15.26365428",
"source": "medRxiv, 16 October 2026",
"paper_title": "Wildfire smoke leaves a large five-year imprint on mortality in the United States",
"authors": "Zhang W, Su H, Ni R, Tao S, Lelieveld J, Cheng Y",
"doi": "10.64898/2026.10.15.26365428",
"type": "Preprint",
"design": "County-month panel of US wildfire PM2.5 and mortality, 2011-2023, deconvolved impulse-response estimation of lagged excess deaths",
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},
{
"kind": "item",
"title": "Health opportunity cost estimates updated for 92 low- and middle-income countries",
"excerpt": "The marginal cost per DALY averted ranges from about $54 to $18,547 across 92 low- and middle-income countries.",
"url": "https://www.coios.me/health-opportunity-cost-estimates-updated-for-92-low-and/",
"published_at": "2026-10-17T09:19:24.000Z",
"updated_at": "2026-10-18T12:15:59.000Z",
"domain": "Data, models and systems",
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"countries": [
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"country_codes": [
"world"
],
"source_type": "preprint",
"verdict": "refines",
"source_url": "https://doi.org/10.64898/2026.03.31.26349880",
"source": "medRxiv, 15 October 2026",
"paper_title": "Updated Health Opportunity Cost Estimates for 92 Low- and Middle-Income Countries: Implications for Global Health Financing and Donor Allocation",
"authors": "Ochalek JM",
"doi": "10.64898/2026.03.31.26349880",
"type": "Preprint",
"design": "Economic modelling study applying previously estimated expenditure–outcome elasticities (Ochalek et al. 2018) to recent mortality, morbidity, population and government health expenditure data for 92 low- and middle-income countries, with two allocation scenarios",
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"attention": "1 citation (Crossref) · as of 2026-10-18",
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},
{
"kind": "item",
"title": "Since 2021, low vaccine coverage predicts larger measles outbreaks in US counties",
"excerpt": "Since 2021, US counties with lower vaccine coverage have had larger measles outbreaks, and spread to neighbouring counties has increased.",
"url": "https://www.coios.me/since-2021-low-vaccine-coverage-predicts-larger-measles/",
"published_at": "2026-10-17T09:15:16.000Z",
"updated_at": "2026-10-18T12:16:00.000Z",
"domain": "Tomorrow's world",
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"countries": [
"United States"
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"country_codes": [
"us"
],
"source_type": "preprint",
"verdict": "refines",
"source_url": "https://doi.org/10.64898/2026.10.14.26365590",
"source": "medRxiv, 16 October 2026",
"paper_title": "Epidemiologic shifts predict spatial patterns of measles re-emergence in the United States",
"authors": "Kumar CK, Stoffel LA, Warren JL, Blumberg S, Schechter R, Bubar KM et al.",
"doi": "10.64898/2026.10.14.26365590",
"type": "Preprint",
"design": "Ecological analysis of annual US county-level measles cases and vaccine coverage, 2011-2025, with spatial statistical prediction model validated 2021-2025",
"coverage": "",
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{
"kind": "item",
"title": "Type 2 diabetes being diagnosed at older ages in Israel, and with more co-morbidities",
"excerpt": "Median age at diagnosis rose from 63.0 to 66.7 years between 2005-2008 and 2020-2023 in one Israeli health system.",
"url": "https://www.coios.me/type-2-diabetes-being-diagnosed-at-older-ages-in-israel-and/",
"published_at": "2026-10-17T09:14:15.000Z",
"updated_at": "2026-10-18T12:16:00.000Z",
"domain": "Health today",
"drivers": [
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"countries": [
"Israel"
],
"country_codes": [
"il"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1007/s00125-026-06901-4",
"source": "Diabetologia, 16 October 2026",
"paper_title": "Evolving phenotype of newly diagnosed type 2 diabetes: a 15-year population-based comparison",
"authors": "Kirshner D, Hauzer M",
"doi": "10.1007/s00125-026-06901-4",
"type": "Peer-reviewed article",
"design": "Retrospective cohort comparison of two periods in one Israeli integrated health system: incident type 2 diabetes 2005-2008 (n=80,201) vs 2020-2023 (n=101,392)",
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"kind": "item",
"title": "Short telomeres, not epigenetic or proteomic ageing, raise interstitial lung disease risk",
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"updated_at": "2026-10-18T12:16:00.000Z",
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"source_url": "https://doi.org/10.64898/2026.10.14.26364960",
"source": "medRxiv, 15 October 2026",
"paper_title": "Short telomeres, but not accelerated epigenetic or proteomic age, increase fibrotic lung disease risk: Mendelian randomisation with pleiotropy dissection and independent replication",
"authors": "Hanke S",
"doi": "10.64898/2026.10.14.26364960",
"type": "Preprint",
"design": "Two-sample bidirectional Mendelian randomisation, six ageing measures against six immune-mediated diseases (36 pairs) in FinnGen R12, with pleiotropy dissection and replication in 5,159 European and 1,210 East Asian IPF cases",
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{
"kind": "item",
"title": "VES001, an oral sortilin inhibitor, raised plasma and CSF progranulin in healthy adults",
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"url": "https://www.coios.me/ves001-an-oral-sortilin-inhibitor-raised-plasma-and-csf/",
"published_at": "2026-10-17T09:02:11.000Z",
"updated_at": "2026-10-18T12:16:00.000Z",
"domain": "Tomorrow's world",
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"Dementia"
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"source_type": "peer-reviewed",
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"source_url": "https://doi.org/10.1038/s41467-026-77638-2",
"source": "Nature Communications, 14 October 2026",
"paper_title": "Preclinical and clinical investigation of VES001, an oral small molecule sortilin receptor inhibitor for the treatment of frontotemporal dementia: a first-in-human randomized placebo-controlled phase 1 trial",
"authors": "Klem L, Dumas D, Swift IJ, Frandsen SL, Mikkelsen DN, Fensbaek L et al.",
"doi": "10.1038/s41467-026-77638-2",
"type": "Peer-reviewed article",
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"title": "Cervical cancer screening rises but gaps persist in US medical records, 2019-2024",
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"published_at": "2026-10-17T09:00:19.000Z",
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"United States"
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1001/jamanetworkopen.2026.39938",
"source": "JAMA Network Open, 16 October 2026",
"paper_title": "Cervical Cancer Screening Rates by Race and Ethnicity, Age, Language, and Census Region",
"authors": "Xie Y, Nguyen L, Le YC, Zamorano A",
"doi": "10.1001/jamanetworkopen.2026.39938",
"type": "Peer-reviewed article",
"design": "Repeated cross-sectional analysis of a US electronic medical record database, women aged 21-64, approximately 9-16 million patients per year, 2019-2024",
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"granularity": "",
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"access": "",
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{
"kind": "item",
"title": "Machine learning beat risk scores for predicting AF recurrence after catheter ablation",
"excerpt": "Across 11 studies, machine learning pooled a C-statistic of 0.80 for AF recurrence after ablation, against 0.58 for traditional scores.",
"url": "https://www.coios.me/machine-learning-beat-risk-scores-for-predicting-af/",
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"source_url": "https://doi.org/10.1016/j.cpcardiol.2026.103484",
"source": "Current Problems in Cardiology, 15 October 2026",
"paper_title": "Machine-learning versus traditional scoring methods for prediction of atrial fibrillation recurrence after catheter ablation: A systematic review and meta-analysis",
"authors": "Koh T, Jeong S, Dababneh E, Lal V, Hughes I, Nayyar S",
"doi": "10.1016/j.cpcardiol.2026.103484",
"type": "Peer-reviewed article",
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"kind": "item",
"title": "Life expectancy gap for hospitalised psychiatric illness narrowed in Queensland, 2009-2023",
"excerpt": "The life expectancy gap at age 18 narrowed in both sexes over 14 years, but not in schizophrenia.",
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"published_at": "2026-10-16T13:28:18.000Z",
"updated_at": "2026-10-18T12:16:01.000Z",
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"au"
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"source_url": "https://doi.org/10.1016/j.lanwpc.2026.101978",
"source": "The Lancet Regional Health - Western Pacific, 10 October 2026",
"paper_title": "Change in the life expectancy gap among people with mental illness: a 14-year population-based cohort study in Australia",
"authors": "Trott M, Lawrence D, Halstead S, Bull C, Siskind D, Kisely S",
"doi": "10.1016/j.lanwpc.2026.101978",
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{
"kind": "item",
"title": "Tirzepatide price rise shifted UK self-paying patients to semaglutide",
"excerpt": "Among 1,033,522 UK adults self-funding GLP-1 treatment, semaglutide initiation rose 31 percentage points in the month tirzepatide's list price rose.",
"url": "https://www.coios.me/tirzepatide-price-rise-shifted-uk-self-paying-patients-to/",
"published_at": "2026-10-16T13:25:27.000Z",
"updated_at": "2026-10-18T12:16:01.000Z",
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"source_url": "https://doi.org/10.1111/dom.71410",
"source": "Diabetes, Obesity and Metabolism, 15 October 2026",
"paper_title": "Real‐World Treatment Patterns and Weight Outcomes Before and After a Tirzepatide Price Increase in Over One Million Self‐Paying UK Adults With Overweight or Obesity",
"authors": "Dix S, Mulligan A, Ficarelli M, Brooke E, Rosenior‐Patten O, Chen S et al.",
"doi": "10.1111/dom.71410",
"type": "Peer-reviewed article",
"design": "Retrospective cohort of 1,033,522 adults initiating semaglutide or tirzepatide through one UK telehealth provider, May 2024–Jan 2026; segmented interrupted time-series around the Sept 2025 price rise, mixed-effects weight trajectories",
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{
"kind": "item",
"title": "Dementia incidence 9.7 per 1000 person-years, higher in low- and middle-income countries",
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"url": "https://www.coios.me/dementia-incidence-9-7-per-1000-person-years-higher-in-low/",
"published_at": "2026-10-16T13:22:22.000Z",
"updated_at": "2026-10-18T12:16:01.000Z",
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"verdict": "refines",
"source_url": "https://doi.org/10.1001/jamaneurol.2026.3540",
"source": "JAMA Neurology, 12 October 2026",
"paper_title": "Global Incidence of All-Cause Dementia",
"authors": "Vella AS, Visontay R, Lipnicki DM, Nichols E, Steinmetz JD, Vos T et al.",
"doi": "10.1001/jamaneurol.2026.3540",
"type": "Peer-reviewed article",
"design": "Two-step individual participant-data meta-analysis of 22 population-based longitudinal cohorts (COSMIC), n=38,418, 287,632 person-years, baselines 1990-2011 with follow-up to 2021, clinically diagnosed dementia",
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{
"kind": "item",
"title": "Austrian opioid agonist treatment cohort has excess mortality across all major causes",
"excerpt": "Among 26,031 people in Austria's opioid agonist treatment registry, all-cause mortality was 7.06 times the general population rate in women and 3.86 times in men.",
"url": "https://www.coios.me/austrian-opioid-agonist-treatment-cohort-has-excess/",
"published_at": "2026-10-16T13:20:29.000Z",
"updated_at": "2026-10-18T12:16:01.000Z",
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"country_codes": [
"at"
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"source_url": "https://doi.org/10.1159/ear/acrag005",
"source": "European Addiction Research, 15 October 2026",
"paper_title": "Mortality and causes of death among individuals in a national opioid agonist treatment cohort",
"authors": "Schwarz T, Anzenberger J, Busch M, Schernhammer ES, Strohmaier S",
"doi": "10.1159/ear/acrag005",
"type": "Peer-reviewed article",
"design": "Retrospective national cohort, 26,031 people in the Austrian OAT registry 2002-2019 linked to the death registry, followed to 2021; 278,959 person-years, 2,358 deaths; SMRs and standardised rate ratios",
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"kind": "item",
"title": "CYP2D6 phenotype predicts metoprolol heart-rate response but not discontinuation",
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"url": "https://www.coios.me/cyp2d6-phenotype-predicts-metoprolol-heart-rate-response/",
"published_at": "2026-10-16T13:18:17.000Z",
"updated_at": "2026-10-18T12:16:02.000Z",
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"source_url": "https://doi.org/10.14740/jocmr6673",
"source": "Journal of Clinical Medicine Research, 14 October 2026",
"paper_title": "Cytochrome P450 2D6 Metabolizer Phenotype Is Associated With Metoprolol Pharmacodynamics But Not With Metoprolol Discontinuation: A Retrospective Cohort Study in the All of Us Research Program",
"authors": "Kachhadia M, Puri P, Buha N, Vadodariya J, Kant S, Giknavorian H et al.",
"doi": "10.14740/jocmr6673",
"type": "Peer-reviewed article",
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"kind": "item",
"title": "NHS online diabetes self-management service modelled at £13,192 per QALY",
"excerpt": "A patient-level simulation of an NHS online service for type 2 diabetes estimated a gain of 0.016 QALYs and a net cost of £216 per user.",
"url": "https://www.coios.me/nhs-online-diabetes-self-management-service-modelled-at-13/",
"published_at": "2026-10-16T13:12:53.000Z",
"updated_at": "2026-10-18T12:16:02.000Z",
"domain": "Data, models and systems",
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"source_url": "https://doi.org/10.1111/dme.70490",
"source": "Diabetic Medicine, 14 October 2026",
"paper_title": "Estimating the long‐term cost‐effectiveness of a free online Diabetes Self‐Management Education and Support service in England: Healthy living for people with type 2 diabetes , using a matched cohort study design",
"authors": "Paterson L, Zghebi SS, Kontopantelis E, Cotterill S, Lowndes E, McMillan B et al.",
"doi": "10.1111/dme.70490",
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"kind": "item",
"title": "Cancer in Japanese adults aged 85 and over rose more than four-fold between 1995 and 2020",
"excerpt": "Registry data show cancer cases in the oldest-old rising 5.9% a year, reaching 15.7% of all Japanese cases by 2020.",
"url": "https://www.coios.me/cancer-in-japanese-adults-aged-85-and-over-rose-more-than/",
"published_at": "2026-10-16T13:10:14.000Z",
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"source_url": "https://doi.org/10.1002/ijc.70797",
"source": "International Journal of Cancer, 15 October 2026",
"paper_title": "Cancer in the Oldest‐Old in Super‐Aging Japan: Trends and Characteristics From National Registry Data",
"authors": "Tanaka S, Tanaka H, Katanoda K",
"doi": "10.1002/ijc.70797",
"type": "Peer-reviewed article",
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"kind": "item",
"title": "Digital outreach on lung screening eligibility reached 11% of invitees in North Carolina",
"excerpt": "Of 26,909 adults invited by patient portal or text, 11% completed lung screening eligibility questions within 16 weeks, with lower reach among Black and Hispanic patients.",
"url": "https://www.coios.me/digital-outreach-on-lung-screening-eligibility-reached-11/",
"published_at": "2026-10-16T13:08:40.000Z",
"updated_at": "2026-10-18T12:16:02.000Z",
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"source_url": "https://doi.org/10.1007/s11606-026-10895-5",
"source": "Journal of General Internal Medicine, 13 October 2026",
"paper_title": "Using Digital Outreach to Identify Individuals Eligible for Lung Cancer Screening: A Secondary Analysis of a Randomized Trial",
"authors": "Bundy R, Snavely AC, Miller DP, Reuland DS, Ferrari RM, Bellinger C et al.",
"doi": "10.1007/s11606-026-10895-5",
"type": "Peer-reviewed article",
"design": "Secondary analysis of a pragmatic multisite randomised trial; 26,909 invited adults aged 50-77 with smoking history, two North Carolina health systems, 16-week reach window; trial registered 2019",
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"kind": "item",
"title": "Worklessness through ill health in England rose fastest among non-drinkers, 2014 to 2025",
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"url": "https://www.coios.me/worklessness-through-ill-health-in-england-rose-fastest/",
"published_at": "2026-10-16T13:05:57.000Z",
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1111/add.70633",
"source": "Addiction, 14 October 2026",
"paper_title": "Alcohol consumption and health‐related economic inactivity among working‐age adults in England: A population study, 2014 to 2025",
"authors": "Jackson SE, Oldham M, Britton A, Brown J",
"doi": "10.1111/add.70633",
"type": "Peer-reviewed article",
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"kind": "item",
"title": "Dexamphetamine persists longer than methylphenidate over 12 months in adults with ADHD",
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"url": "https://www.coios.me/dexamphetamine-persists-longer-than-methylphenidate-over-12/",
"published_at": "2026-10-16T13:05:13.000Z",
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"source_url": "https://doi.org/10.1111/acps.70150",
"source": "Acta Psychiatrica Scandinavica, 15 October 2026",
"paper_title": "Stimulant Persistence in Adult ADHD : A Retrospective Analysis of a Large Clinical Cohort",
"authors": "Wettstein R, Pirgon E, Kroesen J, Navarro‐Ovando V, Kroesen JC, Mathôt R et al.",
"doi": "10.1111/acps.70150",
"type": "Peer-reviewed article",
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"kind": "item",
"title": "Tirzepatide versus dulaglutide in type 2 diabetes, by heart failure status",
"excerpt": "Tirzepatide gave a hazard ratio of 0.83 for all-cause death or heart failure events in those with prior heart failure.",
"url": "https://www.coios.me/tirzepatide-versus-dulaglutide-in-type-2-diabetes-by-heart/",
"published_at": "2026-10-16T13:02:28.000Z",
"updated_at": "2026-10-18T12:16:03.000Z",
"domain": "Health today",
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"source_url": "https://doi.org/10.1093/eurjpc/zwag452",
"source": "European Journal of Preventive Cardiology, 14 October 2026",
"paper_title": "Outcomes in patients with diabetes, atherosclerotic cardiovascular disease, and heart failure treated with tirzepatide or dulaglutide: SURPASS-CVOT analysis",
"authors": "Nicholls SJ, Pavo I, Bhatt DL, Buse JB, Del Prato S, Franco DR et al.",
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{
"kind": "item",
"title": "Friend isolation, not family isolation, is linked to mortality in disaster survivors",
"excerpt": "Among 9311 earthquake survivors followed 5.9 years, isolation from friends was associated with an adjusted hazard ratio for death of 1.28.",
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"published_at": "2026-10-16T13:00:23.000Z",
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"countries": [
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"country_codes": [
"jp"
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"source_type": "peer-reviewed",
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"source_url": "https://doi.org/10.1016/j.pmedr.2026.103654",
"source": "Preventive Medicine Reports, 14 October 2026",
"paper_title": "Association between types of social isolation and all-cause mortality among the survivors in the disaster-affected area of the great East Japan earthquake: The RIAS study",
"authors": "Kanda S, Takusari E, Shimoda H, Sakata K, Tanno K",
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{
"kind": "item",
"title": "Social connection clusters and mortality in 2 265 older adults in Santiago, Chile",
"excerpt": "Clusters lacking a partner, social participation or perceived support had higher all-cause mortality among older Chileans without multimorbidity at baseline.",
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"published_at": "2026-10-16T13:00:04.000Z",
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"cl"
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"source_type": "peer-reviewed",
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"source_url": "https://doi.org/10.21149/17525",
"source": "Salud Pública de México, 14 October 2026",
"paper_title": "Social connections and mortality in Chilean older adults: analysis of 20 years of follow-up",
"authors": "De Albuquerque-Araújo L, Icaza-Noguera G, Márquez-Jara C, Albala-Brevis C",
"doi": "10.21149/17525",
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},
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"kind": "item",
"title": "BCG immunotherapy lowers HbA1c for up to eight years in long-standing type 1 diabetes",
"excerpt": "HbA1c fell 7.04% from baseline at year 5 and 12.84% at year 8 with BCG, unchanged on placebo.",
"url": "https://www.coios.me/bcg-immunotherapy-lowers-hba1c-for-up-to-eight-years-in/",
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"updated_at": "2026-10-18T12:16:03.000Z",
"domain": "Tomorrow's world",
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"United States"
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"country_codes": [
"us"
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"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.10.09.26365133",
"source": "medRxiv, 14 October 2026",
"paper_title": "Immune Training with BCG therapy in Diabetes: Outcomes of a Phase 2 randomized clinical trial",
"authors": "Faustman DL, Braley JE, Hullavarad NS, Bulczynski ER, Dorsey JL, Kartsounis NG et al.",
"doi": "10.64898/2026.10.09.26365133",
"type": "Preprint",
"design": "Randomised double-blind placebo-controlled phase 2 trial in long-standing type 1 diabetes, follow-up to 8 years; sample size not stated",
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{
"kind": "item",
"title": "Life expectancy in 28 countries modelled by machine learning on six drivers",
"excerpt": "Machine learning on a 28-country panel found a concave income-longevity link, and projected mean life expectancy of 78.21 years in 2032 under baseline against 78.98 under an integrated prevention scenario.",
"url": "https://www.coios.me/life-expectancy-in-28-countries-modelled-by-machine/",
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"countries": [
"World"
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"world"
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://link.springer.com/article/10.1186/s12963-026-00517-x",
"source": "Population Health Metrics, 15 October 2026",
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},
{
"kind": "item",
"title": "Three in five women aged 30-49 have never had cervical screening",
"excerpt": "Three in five women aged 30-49 worldwide have never been screened for cervical cancer, and 92% have never had an HPV test.",
"url": "https://www.coios.me/three-in-five-women-aged-30-49-have-never-had-cervical/",
"published_at": "2026-10-15T07:52:09.000Z",
"updated_at": "2026-10-18T12:16:04.000Z",
"domain": "Health today",
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"World"
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"country_codes": [
"world"
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(26)00206-8/fulltext?rss=yes",
"source": "The Lancet Global Health, 14 October 2026",
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"authors": "",
"doi": "",
"type": "Peer-reviewed article",
"design": "Review and synthetic analysis of national survey and programme data, 2022 reference year, women aged 30-49 worldwide",
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},
{
"kind": "item",
"title": "Adding nutrition therapy to tirzepatide tracked with 19.7% weight loss against 15.6%",
"excerpt": "In a telemedicine obesity programme of 4,269 adults, GLP-1-naive tirzepatide users given individualised carbohydrate-reduced nutrition therapy lost 19.7% of body weight at 12 months, as compared to 15.6% without it.",
"url": "https://www.coios.me/adding-nutrition-therapy-to-tirzepatide-tracked-with-19-7/",
"published_at": "2026-10-15T07:41:33.000Z",
"updated_at": "2026-10-18T12:16:04.000Z",
"domain": "Health today",
"drivers": [
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"United States"
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"source_type": "preprint",
"verdict": "refines",
"source_url": "https://doi.org/10.64898/2026.10.09.26365158",
"source": "medRxiv, 13 October 2026",
"paper_title": "Real-World Twelve-Month Weight Loss Outcomes in a Comprehensive Obesity Care Program Utilizing Individualized Nutrition Therapy and Incretin-Based Obesity Medications",
"authors": "Athinarayanan S, Zoller AR, Bergethon KE, Goss AM, Gower BA",
"doi": "10.64898/2026.10.09.26365158",
"type": "Preprint",
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},
{
"kind": "item",
"title": "Vaccinated adults had a quarter lower odds of long COVID in the Omicron era",
"excerpt": "An updated meta-analysis of 18 observational studies estimated the odds of long COVID at 0.75 in vaccinated adults against unvaccinated, and 0.63 for boosted against primary course only.",
"url": "https://www.coios.me/vaccinated-adults-had-a-quarter-lower-odds-of-long-covid-in/",
"published_at": "2026-10-15T07:31:13.000Z",
"updated_at": "2026-10-18T12:16:04.000Z",
"domain": "Behavioural science",
"drivers": [
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"countries": [
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"country_codes": [
"eu"
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"source_type": "preprint",
"verdict": "confirms",
"source_url": "https://doi.org/10.64898/2026.10.12.26365288",
"source": "medRxiv, 13 October 2026",
"paper_title": "The impact of COVID-19 vaccination on long COVID prevention in the Omicron era: An updated systematic review and meta-analysis",
"authors": "Marjenberg Z, Peluso MJ, Wynberg E, Abduljawad S",
"doi": "10.64898/2026.10.12.26365288",
"type": "Preprint",
"design": "Updated systematic review and meta-analysis of observational studies in adults; 18 studies pooled (13 in main comparison), searches to July 2026",
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"granularity": "",
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},
{
"kind": "item",
"title": "Mortality models after intracerebral haemorrhage add little to the Glasgow Coma Scale",
"excerpt": "Models using the first 24 hours of ICU data after intracerebral haemorrhage reached external AUROCs of 0.80 to 0.85, against 0.78 to 0.81 for the Glasgow Coma Scale alone.",
"url": "https://www.coios.me/mortality-models-after-intracerebral-haemorrhage-add-little/",
"published_at": "2026-10-15T07:26:41.000Z",
"updated_at": "2026-10-18T12:16:04.000Z",
"domain": "Data, models and systems",
"drivers": [
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"countries": [
"United States"
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"country_codes": [
"us"
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"source_type": "preprint",
"verdict": "refines",
"source_url": "https://doi.org/10.64898/2026.10.11.26365237",
"source": "medRxiv, 13 October 2026",
"paper_title": "Development and Cross-Database External Validation of 24-Hour Landmark Models for ICU Mortality After Intracerebral Hemorrhage: Incremental Value of Routine Coagulation Markers",
"authors": "Pathak S, Si Y, Sanjaya J, Haghi M, Kudrot NT, Placencia G et al.",
"doi": "10.64898/2026.10.11.26365237",
"type": "Preprint",
"design": "Prediction model development and cross-database external validation; MIMIC-IV development cohort n=2,669 (388 ICU deaths), eICU-CRD validation n=396 and n=1,555",
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},
{
"kind": "item",
"title": "Automated coronary calcium scoring stratified risk better than expert reading",
"excerpt": "Tested in 5,969 patients, an automated coronary calcium model stratified risk of death or myocardial infarction better than experts reading the same low-dose CT scans.",
"url": "https://www.coios.me/automated-coronary-calcium-scoring-stratified-risk-better/",
"published_at": "2026-10-14T13:18:24.000Z",
"updated_at": "2026-10-18T12:16:05.000Z",
"domain": "Data, models and systems",
"drivers": [
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"country_codes": [],
"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.07.02.26356002",
"source": "medRxiv, 12 October 2026",
"paper_title": "Cross-Domain Knowledge Transfer from Expert-Annotated Gated CT via Synthetic Ungated CT Improves Coronary Artery Calcium Scoring on CT Attenuation Correction Scans",
"authors": "Shanbhag A, Miller RJ, Killekar A, Marcinkiewicz AM, Zhou J, Lemley M et al.",
"doi": "10.64898/2026.07.02.26356002",
"type": "Preprint",
"design": "Deep-learning model trained on synthetic ungated CT derived from labelled gated scans, externally tested in 5,969 patients at two centres",
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"granularity": "",
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},
{
"kind": "item",
"title": "More days above the WHO daily NO2 guideline are followed by faster cognitive decline",
"excerpt": "Among 12,235 English adults aged 50 and over, more days above the WHO daily NO2 guideline were followed by faster decline in memory and fluency, independent of annual mean exposure.",
"url": "https://www.coios.me/increased-exposure-above-the-who-daily-no2-guideline-leads/",
"published_at": "2026-10-14T13:05:36.000Z",
"updated_at": "2026-10-18T12:16:05.000Z",
"domain": "Tomorrow's world",
"drivers": [
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"driver_slugs": [
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"countries": [
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"country_codes": [
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"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.09.23.26363787",
"source": "medRxiv, 12 October 2026",
"paper_title": "Daily Exceedance of World Health Organization Air Pollutant Guidelines and Cognitive Aging",
"authors": "Bloomberg M, Di Gessa G, Sholes S, Gasparrini A, de la Cruz Libardi A, Steptoe A et al.",
"doi": "10.64898/2026.09.23.26363787",
"type": "Preprint",
"design": "Prospective cohort, English Longitudinal Study of Ageing waves 1-10 (2002-03 to 2021-23), n=12,235 aged 50+",
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},
{
"kind": "item",
"title": "Cancer cachexia episodes coincide with disease progression and lower survival",
"excerpt": "In 52,236 patients with cancer, cachectic weight loss episodes occurred at times of disease progression, were linked to lower survival, and were more common in tumours with TP53 mutations.",
"url": "https://www.coios.me/cancer-cachexia-episodes-coincide-with-disease-progression/",
"published_at": "2026-10-14T13:00:49.000Z",
"updated_at": "2026-10-18T12:16:05.000Z",
"domain": "Health today",
"drivers": [
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"d-cancer"
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"countries": [],
"country_codes": [],
"source_type": "peer-reviewed",
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"source_url": "https://www.nature.com/articles/s41591-026-04720-z",
"source": "Nature Medicine, 13 October 2026",
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"authors": "",
"doi": "",
"type": "Peer-reviewed article",
"design": "Retrospective cohort using routine clinical records and tumour genotyping, n=52,236 patients with cancer",
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},
{
"kind": "item",
"title": "Published rules for detecting statin intolerance agree poorly with Australian GP records",
"excerpt": "Statin intolerance was recorded in 5.09% of Australian primary-prevention statin users, and none of six published rules for detecting it from records matched a locally developed reference standard consistently.",
"url": "https://www.coios.me/published-rules-for-detecting-statin-intolerance-agree/",
"published_at": "2026-10-14T12:42:11.000Z",
"updated_at": "2026-10-18T12:16:05.000Z",
"domain": "Data, models and systems",
"drivers": [
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"countries": [
"Australia"
],
"country_codes": [
"au"
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"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.1101/2025.11.04.25339533",
"source": "medRxiv, 12 October 2026",
"paper_title": "Electronic health record (EHR)-detectable statin intolerance phenotypes: Prevalence and validation in real-world general practice",
"authors": "Rakhshanda S, Rhee J, Liaw S, Rye K, Jonnagaddala J",
"doi": "10.1101/2025.11.04.25339533",
"type": "Preprint",
"design": "Implementation and validation of six published EHR phenotyping algorithms against a locally developed reference standard in an Australian general-practice research network dataset",
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"attention": "1 citation (Crossref) · as of 2026-10-15",
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},
{
"kind": "item",
"title": "Swedish resource SIMPLER links 107,000 adults' diet data to national registers",
"excerpt": "The Swedish research infrastructure SIMPLER brings together two cohorts, 61,433 women recruited in 1987-90 and 45,906 men in 1997, with repeated diet questionnaires, register linkage and stored biological samples.",
"url": "https://www.coios.me/swedish-resource-simpler-links-107-000-adults-diet-data-to/",
"published_at": "2026-10-13T06:41:46.000Z",
"updated_at": "2026-10-18T12:16:05.000Z",
"domain": "Data, models and systems",
"drivers": [
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],
"country_codes": [
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"source_type": "peer-reviewed",
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"source_url": "https://link.springer.com/article/10.1007/s10654-026-01455-6",
"source": "European Journal of Epidemiology, 12 October 2026",
"paper_title": "",
"authors": "",
"doi": "",
"type": "Peer-reviewed article",
"design": "Cohort profile of two Swedish prospective cohorts, 61,433 women recruited 1987-90 and 45,906 men recruited 1997, linked to national registers",
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},
{
"kind": "item",
"title": "Sixty of 99 dietary factors are associated with hip fracture in UK women",
"excerpt": "Among 541,887 UK postmenopausal women followed for about 20 years, 60 of 99 dietary factors were associated with hip fracture risk after correction for multiple testing.",
"url": "https://www.coios.me/sixty-of-99-dietary-factors-are-associated-with-hip/",
"published_at": "2026-10-13T06:40:55.000Z",
"updated_at": "2026-10-18T12:16:06.000Z",
"domain": "Health today",
"drivers": [
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"Diet, exercise and sleep",
"What linked data reveals"
],
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"d-diet-activity",
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"countries": [
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"country_codes": [
"gb"
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://link.springer.com/article/10.1007/s10654-026-01466-3",
"source": "European Journal of Epidemiology, 12 October 2026",
"paper_title": "",
"authors": "",
"doi": "",
"type": "Peer-reviewed article",
"design": "Prospective cohort (Million Women Study), 541,887 postmenopausal women, 27,318 incident hip fractures, ~19.7 years' follow-up, 99 dietary factors",
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"granularity": "",
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"access": "",
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},
{
"kind": "item",
"title": "Drug-poisoning deaths are set against the change in US life expectancy, 2019 to 2024",
"excerpt": "A cross-sectional study examines how far changes in drug-poisoning deaths account for the change in US life expectancy between 2019 and 2024.",
"url": "https://www.coios.me/drug-poisoning-deaths-are-set-against-the-change-in-us-life/",
"published_at": "2026-10-13T06:20:18.000Z",
"updated_at": "2026-10-18T12:16:06.000Z",
"domain": "Behavioural science",
"drivers": [
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],
"driver_slugs": [
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"countries": [
"United States"
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"country_codes": [
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"paper_title": "Carbonaceous Components Underlying Wildfire Smoke PM 2.5 -Associated Alzheimer's Disease and Related Dementias in Older US Adults",
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"source": "medRxiv, 11 October 2026",
"paper_title": "Large-scale assessment of socioeconomic, demographic and health system structures with US county excess mortality, 2020-2024",
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"paper_title": "MID-LIFE LEISURE-TIME PHYSICAL ACTIVITY IS ASSOCIATED WITH LOWER HIP FRACTURE RISK IN UK BIOBANK",
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"source": "medRxiv, 11 October 2026",
"paper_title": "Evaluating the impact of Advice and Guidance on diagnostic pathways and healthcare use in England: retrospective cohort study, 2015-2022",
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"url": "https://www.coios.me/top-10-by-polygenic-risk-carry-a-fifth-of-taiwan-s-atrial/",
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"paper_title": "Burden of Non-Communicable Diseases Attributable to Polygenic Risk and Its Association with Healthcare Utilization in Taiwan",
"authors": "Shih M, Ke Y, Chang X, Wang L, Feng YA",
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"kind": "item",
"title": "Higher HPV antibody levels are associated with greater vaccine efficacy across types",
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"source_url": "https://doi.org/10.1101/2025.11.26.25341002",
"source": "medRxiv, 9 October 2026",
"paper_title": "HPV binding antibodies are associated with protection: a meta-analysis",
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"kind": "item",
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"source_url": "https://doi.org/10.64898/2026.08.24.26361177",
"source": "medRxiv, 9 October 2026",
"paper_title": "Fine-mapping HLA-II haplotypes in Alzheimer's disease and healthy longevity reveals distinct associations with microglial HLA-II load and neuropathology",
"authors": "Alvarez Sirvent D, Luimes MC, Tesi N, Rohde SK, Salazar AN, Bijker LJ et al.",
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"design": "Case-control fine-mapping of seven HLA-II haplotypes in 6,053 people (443 cognitively healthy centenarians, 3,219 controls, 2,391 Alzheimer's patients), with post-mortem replication in the Netherlands Brain Bank",
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"title": "Severe mental illness costs Norwegian men 1.5 to 19.9 life-years depending on subgroup",
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"url": "https://www.coios.me/severe-mental-illness-costs-norwegian-men-1-5-to-19-9-life/",
"published_at": "2026-10-10T08:20:09.000Z",
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"source_url": "https://doi.org/10.64898/2026.10.05.26364794",
"source": "medRxiv, 7 October 2026",
"paper_title": "Mortality gap continuum in severe mental illness: a nationwide study across healthcare and socioeconomic strata",
"authors": "Hjell G, Hauge LJ, Johansen R, Straiton M, Zahl PH, Haram M et al.",
"doi": "10.64898/2026.10.05.26364794",
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"kind": "item",
"title": "Most adults starting semaglutide or tirzepatide did not continue for a year",
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"url": "https://www.coios.me/us-glp-1-persistence-at-12-months-was-29-9-on-semaglutide/",
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"source_url": "https://doi.org/10.64898/2026.10.04.26364715",
"source": "medRxiv, 6 October 2026",
"paper_title": "Post-Initiation Care Patterns and Weight Loss With Semaglutide and Tirzepatide for Obesity in Clinical Practice",
"authors": "Yang H, Kim C, Ross JS, Huang C, Choi K, Kang B et al.",
"doi": "10.64898/2026.10.04.26364715",
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"kind": "item",
"title": "Twelve-hour emergency stays carry 1.95 times the hospitalisation risk over two years",
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"url": "https://www.coios.me/emergency-stays-of-12-hours-or-more-carry-1-95-times-the/",
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"source_url": "https://doi.org/10.64898/2026.10.05.26364765",
"source": "medRxiv, 7 October 2026",
"paper_title": "Emergency Department Length of Stay, Employment Status, and Subsequent Risk of Hospitalisation: A survival analysis of linked administrative records in England",
"authors": "Aston H, Nafilyan V, Boyle A, Ayoubkhani D",
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"design": "Retrospective cohort, 3,347,008 adults aged 25-64 attending Type 1 EDs in England, April 2021 to March 2023, two-year follow-up, Cox models on linked ECDS-HES-Census 2021-mortality data",
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"kind": "item",
"title": "Summer heat in Italy raises deaths from nervous system and mental illness",
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"url": "https://www.coios.me/heat-attributable-death-fractions-in-italy-are-highest-for/",
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"source_url": "https://doi.org/10.64898/2026.10.02.26364563",
"source": "medRxiv, 6 October 2026",
"paper_title": "Cause-specific mortality attributable to summer heat in Italy, 2004–2023: a nationwide Bayesian spatiotemporal study",
"authors": "Ceccarelli E, Stoppa G, Blangiardo M, Konstantinoudis G, Vanacore N, Jona Lasinio G et al.",
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"design": "Bayesian hierarchical spatiotemporal Poisson analysis of daily deaths by cause, 7,864 Italian municipalities, June-August 2004-2023",
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"title": "Weight-management texts did not reduce weight in postpartum women over 12 months",
"excerpt": "Among 892 postpartum women with a BMI of 25 or more, 12 months of automated weight-management texts made no difference to weight against texts on child health (-0.1 kg).",
"url": "https://www.coios.me/automated-weight-loss-texts-did-not-change-postpartum-women/",
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"source_url": "https://doi.org/10.64898/2026.03.05.26347713",
"source": "medRxiv, 6 October 2026",
"paper_title": "Effectiveness of an automated text message intervention for weight management in postpartum women with overweight or obesity (Supporting MumS (SMS)): a UK wide, multicentre, two arm, parallel group, randomised controlledti trial",
"authors": "Gallagher D, Spyreli E, Calder-MacPhee N, Crossley K, Feuillatre C, Ivory A et al.",
"doi": "10.64898/2026.03.05.26347713",
"type": "Preprint",
"design": "Two-arm parallel randomised controlled trial, 892 postpartum women with BMI 25+, five UK sites, 12 months, enrolled 2022-23",
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"kind": "item",
"title": "Menopausal hormone therapy users had higher breast cancer incidence but lower mortality",
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"url": "https://www.coios.me/hormone-therapy-use-tracked-higher-breast-cancer-incidence/",
"published_at": "2026-10-10T08:08:14.000Z",
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"domain": "Health today",
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"source_url": "https://doi.org/10.64898/2026.10.04.26364714",
"source": "medRxiv, 6 October 2026",
"paper_title": "Menopause timing, hormone therapy, epigenetic aging, and breast cancer outcomes: a secondary analysis of the PLCO Cancer Screening Trial",
"authors": "Zhai T, Pankratz VS, Zychowski KE, Li Y, Leslie KK, Guo Y et al.",
"doi": "10.64898/2026.10.04.26364714",
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"source": "medRxiv, 7 October 2026",
"paper_title": "Rates of oral nicotine pouch experimentation, initiation, and cessation by other tobacco product use and sociodemographic characteristics among U.S. adults, 2022–2024",
"authors": "Roberts OK, Sánchez-Romero LM, Jimenez-Mendoza E, Jeon J, Travis N, Mistry R et al.",
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"title": "Swapping sleep for activity relates to mortality differently in short sleepers",
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"source_url": "https://doi.org/10.1093/aje/kwag249",
"source": "American Journal of Epidemiology, 7 October 2026",
"paper_title": "Reallocation of 24-hour movement behaviour composition and mortality: exploring effect modification by sleep characteristics",
"authors": "Bian W, Ahmadi MN, Mitchell JJ, Biswas RK, Koemel NA, Dumuid D et al.",
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"kind": "item",
"title": "Dutch infant vaccination uptake fell during the pandemic and again after it",
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"source_url": "https://doi.org/10.2807/1560-7917.es.2026.31.40.2600159",
"source": "Eurosurveillance, 8 October 2026",
"paper_title": "Assessing the impact of the COVID-19 pandemic on routine childhood vaccination uptake, the Netherlands, 2016 to 2025",
"authors": "Pijpers J, Haverkate M, van Gaalen R, Hahné S, de Melker H, van den Hof S",
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"kind": "item",
"title": "Modelled extra HPV doses for women with HIV averted cervical cancer",
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"source": "medRxiv, 6 October 2026",
"paper_title": "Optimising HPV Vaccination for Cervical Cancer Prevention in Women Living with HIV: A Cost-Effectiveness Analysis Across 13 African Countries",
"authors": "Ben Miled S, Trabelsi S, Abbas K, Holroyd TA, Trotter CL",
"doi": "10.64898/2026.10.05.26364501",
"type": "Preprint",
"design": "Age-structured Markov model, closed cohort of 100,000 females, calibrated separately to 13 African countries; six HIV-targeted HPV vaccination strategies versus routine two-dose vaccination at 14",
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{
"kind": "item",
"title": "Modelled early pandemic costs rise more from too little control than from too much",
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"url": "https://www.coios.me/modelled-pandemic-costs-rise-far-more-from-under-control/",
"published_at": "2026-10-06T13:10:05.000Z",
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"source_url": "https://doi.org/10.64898/2026.10.02.26363193",
"source": "medRxiv, 5 October 2026",
"paper_title": "Cost-optimal transmission reduction in early pandemic response: a multi-objective health-economic modelling study across 110 countries",
"authors": "Lee J, Chowell G, Mendoza R, Mendoza VM, Thompson RN, Jung E",
"doi": "10.64898/2026.10.02.26363193",
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"kind": "item",
"title": "Dementia mortality is higher where outdoor ultrafine particle levels are higher",
"excerpt": "In 2.1 million adults in Montreal and Toronto, each 10,000 particle/cm3 increase in outdoor ultrafine particle concentration was associated with a 22% higher rate of dementia mortality.",
"url": "https://www.coios.me/ultrafine-particle-exposure-is-linked-to-higher-dementia/",
"published_at": "2026-10-06T13:08:17.000Z",
"updated_at": "2026-10-18T12:16:12.000Z",
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"source_url": "https://doi.org/10.1097/ede.0000000000002054",
"source": "Epidemiology, 5 October 2026",
"paper_title": "Long-term exposure to ultrafine particles and mortality from neurodegenerative diseases: a population-based cohort study",
"authors": "Batisse E, Lloyd M, Renoux C, Ganji A, Xu J, Hatzopoulou M et al.",
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{
"kind": "item",
"title": "Oral safiglipron lowered HbA1c as much as dapagliflozin, and more at 90 mg",
"excerpt": "In adults with type 2 diabetes, once-daily oral safiglipron lowered HbA1c at least as much as dapagliflozin, and by more at the 90 mg dose.",
"url": "https://www.coios.me/oral-safiglipron-was-non-inferior-to-dapagliflozin-on-hba1c/",
"published_at": "2026-10-06T12:58:48.000Z",
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"source_url": "https://www.nature.com/articles/s41591-026-04713-y",
"source": "Nature Medicine, 5 October 2026",
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{
"kind": "item",
"title": "Real cigarette prices rose 2.9% a year across 195 countries",
"excerpt": "Inflation-adjusted cigarette prices across 195 countries rose 2.9% a year between 2008 and 2024, with over a fifth of nominal prices unchanged between successive periods.",
"url": "https://www.coios.me/real-cigarette-prices-rose-2-9-a-year-worldwide-between/",
"published_at": "2026-10-06T12:55:55.000Z",
"updated_at": "2026-10-18T12:16:14.000Z",
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"source_url": "https://doi.org/10.64898/2026.09.28.26364093",
"source": "medRxiv, 5 October 2026",
"paper_title": "Nominal and real cigarette Price trends from a global dataset, 2008-2024 and implications for the World Health Organization’s 3 by 35 initiative: a longitudinal study and forecasting analysis",
"authors": "Cherukupalli R, Sandoval GA, Perucic A, Goodchild M, Paul J",
"doi": "10.64898/2026.09.28.26364093",
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{
"kind": "item",
"title": "Older adults starting GLP-1 drugs were younger and heavier than other initiators",
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"url": "https://www.coios.me/older-glp-1-starters-were-younger-and-healthier-than-those/",
"published_at": "2026-10-06T12:55:32.000Z",
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"source_url": "https://doi.org/10.64898/2026.09.29.26364340",
"source": "medRxiv, 5 October 2026",
"paper_title": "Patterns of GLP-1 Receptor Agonist Initiation Compared With Other Glucose-Lowering and Anti-Obesity Therapies Among Older Adults",
"authors": "Brooks JD, Donahue MA, ElHassan A, Tian J, Hernandez-Diaz S, Blacker D et al.",
"doi": "10.64898/2026.09.29.26364340",
"type": "Preprint",
"design": "Retrospective cohort of 58,754 adults aged 65+ with type 2 diabetes in one regional health system, 2018-2026, comparing new initiators of GLP-1RA (n=5,095), SGLT2i (n=5,483) and DPP-4i (n=1,516)",
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"kind": "item",
"title": "Under 2 mm of Gleason pattern 4 matches favourable intermediate-risk prostate cancer",
"excerpt": "Among 2499 men with Grade Group 2-4 prostate cancer, those with under 2 mm of Gleason pattern 4 had 5-year biochemical recurrence of 20%, matching favourable intermediate-risk disease.",
"url": "https://www.coios.me/total-gleason-pattern-4-length-outperforms-risk-groups-for/",
"published_at": "2026-10-06T12:55:17.000Z",
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"source_url": "https://doi.org/10.1111/bju.70478",
"source": "BJU International, 4 October 2026",
"paper_title": "Gleason pattern 4 length and active surveillance eligibility in Grade Group 2-4 prostate cancer",
"authors": "Fletcher SA, Pickersgill NA, Aiken N, Assel MJ, Liso N, Reuter VE et al.",
"doi": "10.1111/bju.70478",
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"design": "Retrospective cohort of 2499 men with Grade Group 2-4 prostate cancer on MRI-targeted and systematic biopsy followed after radical prostatectomy, with 5-year biochemical recurrence",
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"kind": "item",
"title": "RSV and rhinovirus caused more Brazilian respiratory deaths in 2026 than influenza",
"excerpt": "Brazilian surveillance over 35 weeks of 2026 recorded more severe respiratory deaths from RSV and rhinovirus than from influenza, concentrated in children under 2 and those aged 65 and over.",
"url": "https://www.coios.me/brazil-s-2026-sari-surveillance-classes-6-418-deaths-as/",
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"source_url": "https://doi.org/10.64898/2026.10.03.26364639",
"source": "medRxiv, 5 October 2026",
"paper_title": "Mortality and vaccine-preventable deaths from severe acute respiratory infections in Brazil in 2026",
"authors": "Kupek E",
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"kind": "item",
"title": "One in seven Danish anorexia patients became steadily more ill after diagnosis",
"excerpt": "Among 9,534 Danish patients with anorexia nervosa, one in seven became steadily more ill, with more psychiatric and physical illness in the five years after diagnosis.",
"url": "https://www.coios.me/one-in-seven-danish-anorexia-patients-follows-a-worsening/",
"published_at": "2026-10-06T12:50:32.000Z",
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"source_url": "https://doi.org/10.64898/2026.09.28.26364163",
"source": "medRxiv, 5 October 2026",
"paper_title": "Identifying Register-Based Severity Trajectories in Anorexia Nervosa: Associations with Polygenic Scores, Psychiatric and Somatic Conditions",
"authors": "Abdulkadir M, Larsen JT, Zhang Z, Clausen L, Musliner KL, Bulik CM et al.",
"doi": "10.64898/2026.09.28.26364163",
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"design": "Population-based register cohort, Denmark, 9,534 people with anorexia nervosa born 1969-2013, genetic subsample 5,126",
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"kind": "item",
"title": "An estimated 1.32% of US adults had hepatitis C in 2017-2020",
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"url": "https://www.coios.me/modelled-hepatitis-c-prevalence-ranged-from-0-74-to-2-22/",
"published_at": "2026-10-06T12:45:09.000Z",
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"source_url": "https://doi.org/10.64898/2026.09.29.26364309",
"source": "medRxiv, 5 October 2026",
"paper_title": "Estimating Hepatitis C Virus Prevalence in US States and the District of Columbia, 2017–2020",
"authors": "Bradley H, Yu Y, Li L, Kapadia SN, Sullivan PS, Hall EW",
"doi": "10.64898/2026.09.29.26364309",
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"design": "Bayesian spatial integrated abundance model combining six surveillance, claims and Medicaid data sources, 48 states and DC, 2017-2020",
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"kind": "item",
"title": "Older patients on a virtual ward reported fewer depressive symptoms than inpatients",
"excerpt": "Among 100 patients aged 70 and over, 72% of hospital inpatients screened positive for depressive symptoms as compared to 30% of those cared for on a virtual ward.",
"url": "https://www.coios.me/virtual-ward-patients-aged-70-reported-fewer-depressive/",
"published_at": "2026-10-06T12:30:53.000Z",
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"source_url": "https://doi.org/10.7759/cureus.117440",
"source": "Cureus, 4 October 2026",
"paper_title": "The Psychological Impact of Hospital Admission on the Elderly: A Prospective Comparative Clinical Audit and Service Evaluation",
"authors": "Sameen A, Sarupani P, Angelopoulou A",
"doi": "10.7759/cureus.117440",
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"kind": "item",
"title": "Infection followed hip fracture in 43% of older Danish patients with dementia",
"excerpt": "Among 100,335 Danish hip fracture patients aged 65 and over, infection within 30 days reached 43.0% in those with dementia, as compared to 18.4% in matched comparators with dementia.",
"url": "https://www.coios.me/mental-illness-and-hip-fracture-interact-to-raise-30-day/",
"published_at": "2026-10-05T07:31:49.000Z",
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"country_codes": [
"dk"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1007/s41999-026-01623-7",
"source": "European Geriatric Medicine, 3 October 2026",
"paper_title": "Interaction between mental health conditions and hip fracture on the 30-day risk of infection among older adults: a Danish matched cohort study",
"authors": "Moestrup LJ, Haaber RS, Jensen SS, Vandenbroucke-Grauls C, Pedersen AB",
"doi": "10.1007/s41999-026-01623-7",
"type": "Peer-reviewed article",
"design": "Danish nationwide matched cohort, 100,335 hip fracture patients aged 65+ operated 2004-21 and 498,943 age- and sex-matched comparators",
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{
"kind": "item",
"title": "PSMA-guided radiotherapy did not improve failure-free survival in prostate cancer",
"excerpt": "In a phase 2 trial of 253 men, radiotherapy targeted to every lesion seen on PSMA-PET gave five-year failure-free survival of 66% against 62% for standard care.",
"url": "https://www.coios.me/psma-guided-radiotherapy-missed-its-primary-endpoint-but/",
"published_at": "2026-10-05T07:24:17.000Z",
"updated_at": "2026-10-18T12:16:20.000Z",
"domain": "Health today",
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"Innovation in treatment"
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"d-cancer",
"d-treatment-innovation"
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"countries": [
"Canada"
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"country_codes": [
"ca"
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1016/j.eururo.2026.09.017",
"source": "European Urology, 3 October 2026",
"paper_title": "PSMA-PET/CT-guided Intensification of Radiation Therapy for Prostate Cancer (PSMAgRT): 5-yr Analysis of a Phase 2 Randomized Controlled Trial",
"authors": "Belliveau C, Saad F, Duplan D, Petit C, Delouya G, Lambert C et al.",
"doi": "10.1016/j.eururo.2026.09.017",
"type": "Peer-reviewed article",
"design": "Two-centre phase 2 open-label RCT, 262 randomised (253 analysed) 2018-2021, median follow-up 66 months",
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{
"kind": "item",
"title": "STEMI patients judged at high risk of shock had double the ten-year mortality",
"excerpt": "Among 1,574 Danish STEMI patients treated by primary angioplasty, those a score marked as at high risk of shock in hospital had ten-year mortality of 41% against 20%.",
"url": "https://www.coios.me/orbi-score-marks-larger-infarcts-in-stemi-but-predicts-10/",
"published_at": "2026-10-05T07:20:13.000Z",
"updated_at": "2026-10-18T12:16:21.000Z",
"domain": "Health today",
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"countries": [
"Denmark"
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"dk"
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1093/ehjacc/zuag126",
"source": "European Heart Journal: Acute Cardiovascular Care, 3 October 2026",
"paper_title": "Inflammation, Infarct Size and 10-Year Mortality in STEMI Patients Stratified by the ORBI Risk Score: A DANAMI-3 Sub-study",
"authors": "Kunkel JB, Lønborg J, Frydland M, Özbek BT, Nepper-Christensen L, Vejlstrup N et al.",
"doi": "10.1093/ehjacc/zuag126",
"type": "Peer-reviewed article",
"design": "Sub-study of the DANAMI-3 randomised trials, 1,574 STEMI patients without cardiogenic shock, cardiac MRI infarct size and 10-year registry mortality follow-up",
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},
{
"kind": "item",
"title": "US deaths recording both type 2 diabetes and cardiac arrest rose faster after 2014",
"excerpt": "Deaths of US adults recording both type 2 diabetes and cardiac arrest rose by 2.72% a year to 2014, then by 9.55% a year to 2020.",
"url": "https://www.coios.me/us-deaths-listing-both-type-2-diabetes-and-cardiac-arrest/",
"published_at": "2026-10-05T07:15:48.000Z",
"updated_at": "2026-10-18T12:16:21.000Z",
"domain": "Health today",
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"Health systems and access"
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"United States"
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"us"
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1007/s40615-026-03215-4",
"source": "Journal of Racial and Ethnic Health Disparities, 3 October 2026",
"paper_title": "Sex, Racial/Ethnic, and Regional Disparities in Mortality Involving Both Cardiac Arrest and Type 2 Diabetes Mellitus Among U.S. Adults, 1999-2020",
"authors": "Chaudhary A, Khalid AA, Fawaz-Ur-Rehman, Sabir R, Bashir AMD, Javed R et al.",
"doi": "10.1007/s40615-026-03215-4",
"type": "Peer-reviewed article",
"design": "Serial cross-sectional analysis of US multiple-cause death certificates (CDC WONDER), adults aged 25+, 258,675 deaths, 1999-2020, with Joinpoint regression",
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{
"kind": "item",
"title": "Japanese romosozumab starters had less recent heart attack or stroke than other users",
"excerpt": "Among 311,585 Japanese patients starting romosozumab between 2019 and 2023, 11.7% of men and 7.9% of women had a myocardial infarction or stroke in the prior 360 days, below the 8.9-17.6% among users of other osteoporosis drugs, and those with such a history discontinued more often.",
"url": "https://www.coios.me/japanese-romosozumab-starters-had-less-recent-heart-attack/",
"published_at": "2026-10-05T07:13:44.000Z",
"updated_at": "2026-10-18T12:16:22.000Z",
"domain": "Health today",
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"Japan"
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"jp"
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1007/s00223-026-01613-8",
"source": "Calcified Tissue International, 3 October 2026",
"paper_title": "Romosozumab Prescribing in Relation to Cardiovascular Disease History in Japan: A Nationwide Claims Database Study",
"authors": "Fujita Y, Kouda K, Fujimori K, Okimoto N, Nakatoh S, Tamaki J et al.",
"doi": "10.1007/s00223-026-01613-8",
"type": "Peer-reviewed article",
"design": "Nationwide claims database descriptive study, 311,585 romosozumab initiators, Japan, March 2019 to March 2023",
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},
{
"kind": "item",
"title": "VAERS reports after the 2024-25 COVID-19 vaccine were consistent with earlier seasons",
"excerpt": "A CDC review of 9856 US VAERS reports following the 2024-2025 JN.1-based COVID-19 vaccine found 8.9% serious, eight Guillain-Barre and six myocarditis or myopericarditis cases meeting case definitions, with reporting rates below background rates for both.",
"url": "https://www.coios.me/vaers-reports-after-the-2024-25-covid-19-vaccine-were/",
"published_at": "2026-10-05T06:54:42.000Z",
"updated_at": "2026-10-18T12:16:23.000Z",
"domain": "Behavioural science",
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"United States"
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"us"
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1007/s40264-026-01709-y",
"source": "Drug Safety, 3 October 2026",
"paper_title": "Safety Monitoring of COVID-19 Vaccines in the Vaccine Adverse Event Reporting System (VAERS): United States, August 22, 2024-July 4, 2025",
"authors": "Romanson B, Moro PL, Strid P, Hause A, Stroud E, Marquez PL et al.",
"doi": "10.1007/s40264-026-01709-y",
"type": "Peer-reviewed article",
"design": "Descriptive review of US passive surveillance reports (VAERS), 9856 reports, 22 Aug 2024-4 Jul 2025",
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"attention": "1 citation (Crossref) · as of 2026-10-18",
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},
{
"kind": "item",
"title": "One in five Australian paediatricians surveyed provides vaping cessation support",
"excerpt": "Of 90 paediatricians and registrars surveyed across Australia in 2023, over two-thirds routinely advised adolescents against vaping, but only one in five provided cessation support.",
"url": "https://www.coios.me/few-australian-paediatricians-surveyed-offer-vaping/",
"published_at": "2026-10-05T06:49:53.000Z",
"updated_at": "2026-10-18T12:16:24.000Z",
"domain": "Behavioural science",
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"Australia"
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"country_codes": [
"au"
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1111/jpc.70605",
"source": "Journal of Paediatrics and Child Health, 3 October 2026",
"paper_title": "Paediatricians' Support for Adolescent Vaping Cessation in Australia: A National Cross-Sectional Study",
"authors": "Nimmi N, Joseph B, Bhurawala H, Shah S, Munoz A, Rahman MA",
"doi": "10.1111/jpc.70605",
"type": "Peer-reviewed article",
"design": "National cross-sectional web survey of 90 paediatricians and registrars, Australia, May–October 2023",
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},
{
"kind": "item",
"title": "Machine learning screen finds 17 dietary polyphenols that bind Salmonella proteins",
"excerpt": "A graph neural network screened over 7,000 plant compounds, and laboratory binding assays confirmed that 17 dietary polyphenols attach to two proteins Salmonella uses to coordinate its virulence.",
"url": "https://www.coios.me/screen-flags-17-dietary-polyphenols-that-bind-salmonella/",
"published_at": "2026-10-05T06:48:15.000Z",
"updated_at": "2026-10-18T12:16:24.000Z",
"domain": "Data, models and systems",
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"driver_slugs": [
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1080/19490976.2026.2726629",
"source": "Gut Microbes, 3 October 2026",
"paper_title": "Discovery of dietary polyphenols targeting the autoinducer-2 quorum sensing system of pathogenic bacteria",
"authors": "Wu S, Zhang P, Wang M, Xiao X, Jin H, Zhang H et al.",
"doi": "10.1080/19490976.2026.2726629",
"type": "Peer-reviewed article",
"design": "In-silico screen of >7,000 phytochemicals with a graph neural network classifier, followed by SPR binding, docking, gene expression and cell-adhesion assays in Salmonella Typhimurium LT2 and three other pathogens",
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},
{
"kind": "item",
"title": "Treating drug-resistant TB contacts up to age 45 was modelled as cost-effective",
"excerpt": "A model of 189 countries found that offering preventive treatment to household contacts of drug-resistant tuberculosis up to age 45, rather than only under-15s, was cost-effective in 160 countries.",
"url": "https://www.coios.me/preventive-treatment-to-age-45-for-drug-resistant-tb/",
"published_at": "2026-10-04T06:55:27.000Z",
"updated_at": "2026-10-18T12:16:25.000Z",
"domain": "Data, models and systems",
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"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.10.01.26364489",
"source": "medRxiv, 2 October 2026",
"paper_title": "Household contact management of drug-resistant tuberculosis: a global cost-effectiveness modelling analysis of expanded preventive treatment by age",
"authors": "Mafirakureva N, McQuaid CF, Harker M, Garcia-Prats A, Hesseling AC, Seddon JA et al.",
"doi": "10.64898/2026.10.01.26364489",
"type": "Preprint",
"design": "Decision-analytic cost-effectiveness model of MDR/RR-tuberculosis household contact management in 189 countries, by age band",
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},
{
"kind": "item",
"title": "Overweight/obesity in German children stands at 16.1%, unchanged over two decades",
"excerpt": "Measured height and weight in a representative sample of 3,978 German children aged 4 to 17 gave an overweight and obesity prevalence of 16.1%, with obesity alone at 6.7%.",
"url": "https://www.coios.me/german-child-overweight-and-obesity-prevalence-is-16-1-and/",
"published_at": "2026-10-04T06:45:50.000Z",
"updated_at": "2026-10-18T12:16:26.000Z",
"domain": "Health today",
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"countries": [
"Germany"
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"country_codes": [
"de"
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"source_type": "preprint",
"verdict": "confirms",
"source_url": "https://doi.org/10.64898/2026.10.01.26364513",
"source": "medRxiv, 2 October 2026",
"paper_title": "Population-Based Prevalence of Overweight and Obesity in German Youth: Findings from MoMo 2.0 and Comparison with KiGGS",
"authors": "Lazarides C, Kuhnert R, Schienkiewitz A, Tschuschke L, Klos L, Fiedler J et al.",
"doi": "10.64898/2026.10.01.26364513",
"type": "Preprint",
"design": "Representative cross-sectional survey with measured height and weight, n=3,978 aged 4-17, 2023-2025, aligned to waves back to 2005",
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},
{
"kind": "item",
"title": "Multi-cancer early detection blood test detected 15.4% of stage I cancers",
"excerpt": "A methylation and protein blood test identified 50.9% of cancers across 21 tumour organ types at a specificity of 98.5%, in a multi-centre case-control study of 6,352 samples.",
"url": "https://www.coios.me/multi-cancer-blood-test-detected-15-4-of-stage-i-cancers-at/",
"published_at": "2026-10-04T06:44:50.000Z",
"updated_at": "2026-10-18T12:16:26.000Z",
"domain": "Health today",
"drivers": [
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"What linked data reveals"
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"driver_slugs": [
"d-cancer",
"d-linked-data"
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"countries": [],
"country_codes": [],
"source_type": "peer-reviewed",
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"source_url": "https://doi.org/10.1158/1055-9965.epi-26-0541",
"source": "Cancer Epidemiology, Biomarkers & Prevention, 2 October 2026",
"paper_title": "Performance of a multi-biomarker class, multi-cancer early detection (MCED) blood test in a prospectively collected cohort",
"authors": "Gainullin VG, Manesse M, Zhuang F, Gray M, Hwang HJ, Cerqueira GC et al.",
"doi": "10.1158/1055-9965.epi-26-0541",
"type": "Peer-reviewed article",
"design": "Multi-centre prospectively collected case-control study, 6,352 samples (1,438 cancers, 21 organ types), split into training and test sets",
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"latency": "",
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},
{
"kind": "item",
"title": "Digital reminders raised child vaccination coverage in low- and middle-income countries",
"excerpt": "A meta-analysis of 22 randomised trials in low- and middle-income countries found reminders raised the share of children vaccinated relative to usual care (RR 1.27), though trial results varied widely.",
"url": "https://www.coios.me/digital-reminders-raised-child-vaccination-coverage-in-low/",
"published_at": "2026-10-04T06:44:25.000Z",
"updated_at": "2026-10-18T12:16:27.000Z",
"domain": "Behavioural science",
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"country_codes": [
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1016/j.vaccine.2026.129176",
"source": "Vaccine, 2 October 2026",
"paper_title": "Impact of digital health interventions in improving pediatric immunization coverage and timeliness in low- and middle-income countries: a systematic review and meta-analysis",
"authors": "Samante FLD, Tiu VJU, Cansino EJF, Jose RIL, Capistrano MPR, Aliño PAL et al.",
"doi": "10.1016/j.vaccine.2026.129176",
"type": "Peer-reviewed article",
"design": "Systematic review and meta-analysis of 22 randomised controlled trials, 68,664 participants, in low- and middle-income countries",
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},
{
"kind": "item",
"title": "Nigeria's HPV programme is modelled to avert 1.82 million cervical cancers",
"excerpt": "Continuing to vaccinate Nigerian girls aged 9 to 14 is projected to avert 1.82 million cervical cancer cases to 2100, with 945,000 remaining in women already too old.",
"url": "https://www.coios.me/nigeria-s-adolescent-hpv-programme-is-modelled-to-avert-1/",
"published_at": "2026-10-04T06:40:50.000Z",
"updated_at": "2026-10-18T12:16:28.000Z",
"domain": "Data, models and systems",
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"countries": [
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"country_codes": [
"ng"
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"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.09.30.26364434",
"source": "medRxiv, 2 October 2026",
"paper_title": "Model-based evaluation of an infant HPV prophylactic vaccination program in Nigeria",
"authors": "Stuart RM, Blessing UI, Gill C, Cohen JA",
"doi": "10.64898/2026.09.30.26364434",
"type": "Preprint",
"design": "Agent-based HPV microsimulation (HPVsim) calibrated to Nigeria, 50 replicates per scenario, projections 2025-2100",
"coverage": "",
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"latency": "",
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},
{
"kind": "item",
"title": "Tuberculosis vaccine VPM1002 is modelled as stronger against disease outside the lungs",
"excerpt": "A dynamic model of tuberculosis in India estimated the VPM1002 vaccine to be 42.9% effective against disease outside the lungs and 14.0% against lung disease, both intervals including no effect.",
"url": "https://www.coios.me/modelled-vpm1002-effectiveness-in-india-is-42-9/",
"published_at": "2026-10-04T06:40:40.000Z",
"updated_at": "2026-10-18T12:16:29.000Z",
"domain": "Data, models and systems",
"drivers": [
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"countries": [
"India"
],
"country_codes": [
"in"
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"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.07.31.26359434",
"source": "medRxiv, 2 October 2026",
"paper_title": "A disaggregated dynamic model of pulmonary and extrapulmonary tuberculosis for vaccine and booster-schedule evaluation: VPM1002 in India as a case study",
"authors": "Revathy M, Niranjan V, Uttarkar A, Swaminathan V, Carrese A, Bhargava A",
"doi": "10.64898/2026.07.31.26359434",
"type": "Preprint",
"design": "Deterministic dynamic transmission model, 1,152 compartments, calibrated to WHO India data 2015-2024, 1,000 Monte Carlo iterations",
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"attention": "1 citation (Crossref) · as of 2026-10-04",
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},
{
"kind": "item",
"title": "Depression carried a 65% higher rate of new cardiometabolic disease over 15 years",
"excerpt": "Among 1858 Dutch adults followed for 15 years, lifetime major depression was associated with higher cardiometabolic disease incidence (HR 1.65), with no one symptom pattern carrying more risk than another.",
"url": "https://www.coios.me/depression-was-associated-with-65-higher-cardiometabolic/",
"published_at": "2026-10-04T06:38:15.000Z",
"updated_at": "2026-10-18T12:16:29.000Z",
"domain": "Health today",
"drivers": [
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"driver_slugs": [
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"countries": [
"Netherlands"
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"country_codes": [
"nl"
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1016/j.jad.2026.122580",
"source": "Journal of Affective Disorders, 2 October 2026",
"paper_title": "Depressive symptom profiles and risk of cardiometabolic disease incidence",
"authors": "Zwiep JC, Milaneschi Y, Vinkers CH, Giltay EJ, Schroevers RA, Penninx BWJH et al.",
"doi": "10.1016/j.jad.2026.122580",
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{
"kind": "item",
"title": "Two ways of asking about loneliness disagree over graduates in England",
"excerpt": "Among 135,725 adult volunteers in England, university education was associated with higher loneliness on a three-question scale but with lower loneliness when people were asked directly.",
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"source_url": "https://doi.org/10.1186/s44263-026-00335-1",
"source": "BMC Global and Public Health, 2 October 2026",
"paper_title": "Factors associated with loneliness and social capital in a large volunteer sample of adults in England",
"authors": "El-Osta A, Al-Ammouri M, Alaa A, Altalib S, Tristán-López A, Majeed A",
"doi": "10.1186/s44263-026-00335-1",
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"kind": "item",
"title": "Norway's ban on all alcohol advertising has survived 50 years of legal challenge",
"excerpt": "A review of Norwegian government documents, parliamentary papers and court rulings traces the alcohol marketing ban in force since 1975, which has adapted to alcohol-free beers and social media.",
"url": "https://www.coios.me/norway-s-total-alcohol-advertising-ban-has-held-for-50/",
"published_at": "2026-10-04T06:12:25.000Z",
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"Norway"
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"no"
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"source_type": "peer-reviewed",
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"source_url": "https://doi.org/10.1111/add.70621",
"source": "Addiction, 2 October 2026",
"paper_title": "50 years of experience with a comprehensive alcohol advertising ban in Norway",
"authors": "Sørheim SE",
"doi": "10.1111/add.70621",
"type": "Peer-reviewed article",
"design": "Narrative review of government documents, bills, parliamentary reports, court cases and grey literature, 1975-2025",
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},
{
"kind": "item",
"title": "Seven in ten Korean heated tobacco and cigarette users moved to cigarettes",
"excerpt": "Among 7.26 million Korean adults screened between 2019 and 2023, users of heated tobacco or e-cigarettes were more likely to quit cigarettes, but also more likely to start smoking again.",
"url": "https://www.coios.me/most-korean-dual-users-of-heated-tobacco-and-cigarettes/",
"published_at": "2026-10-03T13:25:38.000Z",
"updated_at": "2026-10-18T12:16:31.000Z",
"domain": "Behavioural science",
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"countries": [
"South Korea"
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"country_codes": [
"kr"
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1136/tc-2026-060187",
"source": "Tobacco Control, 30 September 2026",
"paper_title": "Transitions in tobacco product use involving combustible cigarettes, heated tobacco products and electronic cigarettes among 7 million South Korean adults: a prospective cohort study",
"authors": "Huh Y, Kim HR, Lee JA, Cho HJ",
"doi": "10.1136/tc-2026-060187",
"type": "Peer-reviewed article",
"design": "Prospective cohort using Korean National Health Insurance screening records, n=7,260,125 adults, three biennial screenings 2019-2023",
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},
{
"kind": "item",
"title": "Oral orforglipron is tested for cardiovascular safety against insulin in type 2 diabetes",
"excerpt": "A phase 3 trial randomised 2749 adults with type 2 diabetes and heart or kidney disease to oral orforglipron or insulin glargine, and followed them for a median two years.",
"url": "https://www.coios.me/orforglipron-against-insulin-glargine-in-the-achieve-4/",
"published_at": "2026-10-03T13:20:53.000Z",
"updated_at": "2026-10-18T12:16:31.000Z",
"domain": "Tomorrow's world",
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"Heart and stroke",
"Obesity, diabetes and GLP-1"
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"world"
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"source_url": "https://doi.org/10.1016/s0140-6736(26)01865-9",
"source": "The Lancet, 30 September 2026",
"paper_title": "Cardiovascular safety of orforglipron versus insulin glargine in adults with type 2 diabetes at increased cardiovascular risk (ACHIEVE-4): a phase 3, event-driven, randomised, open-label, non-inferiority, active comparator trial",
"authors": "Klein KR, Wysham C, Tuttle KR, Davies MJ, Cox D, Chen J et al.",
"doi": "10.1016/s0140-6736(26)01865-9",
"type": "Peer-reviewed article",
"design": "Phase 3 event-driven randomised open-label active-comparator non-inferiority trial, 2749 adults, 317 sites in 16 countries, median follow-up 2 years, 2023-2024",
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"attention": "1 citation (Crossref) · as of 2026-10-16",
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},
{
"kind": "item",
"title": "Sotagliflozin after worsening heart failure is modelled at $75,510 per QALY gained",
"excerpt": "A lifetime microsimulation of patients with type 2 diabetes after worsening heart failure put sotagliflozin at $75,510 per quality-adjusted life-year gained, at an assumed net cost of $434 a month.",
"url": "https://www.coios.me/sotagliflozin-after-worsening-heart-failure-modelled-at-75/",
"published_at": "2026-10-03T13:15:39.000Z",
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"verdict": "new",
"source_url": "https://doi.org/10.1016/j.amjcard.2026.09.025",
"source": "The American Journal of Cardiology, 30 September 2026",
"paper_title": "Cost-Effectiveness of Sotagliflozin in Heart Failure Patients with Preserved and Reduced Ejection Fractions - Results from SOLOIST-WHF",
"authors": "Zhang Z, Kolm P, Dolman S, Alva M, Andrade K, Bhatt DL et al.",
"doi": "10.1016/j.amjcard.2026.09.025",
"type": "Peer-reviewed article",
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{
"kind": "item",
"title": "England's cervical screening coverage gap by deprivation has widened to 7.4 points",
"excerpt": "Cervical screening coverage in England in 2024 ranged from 73.5% in the least deprived areas to 66.1% in the most deprived, a wider gap than that recorded twelve years earlier.",
"url": "https://www.coios.me/england-s-cervical-screening-deprivation-gap-widened-from-4/",
"published_at": "2026-10-03T13:15:03.000Z",
"updated_at": "2026-10-18T12:16:32.000Z",
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"United Kingdom"
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1177/09691413261484526",
"source": "Journal of Medical Screening, 30 September 2026",
"paper_title": "Socioeconomic inequalities in cervical cancer screening coverage in England",
"authors": "Gilham C",
"doi": "10.1177/09691413261484526",
"type": "Peer-reviewed article",
"design": "Ecological analysis linking 2024 general-practice-level cervical screening coverage in England to area-level index of multiple deprivation, compared with a 2012 linkage",
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{
"kind": "item",
"title": "Never starting anticoagulants in atrial fibrillation carried the highest annual costs",
"excerpt": "Among 47,427 Scots with incident atrial fibrillation, annual healthcare costs were GBP 7,288 per patient on continuous oral anticoagulation and GBP 22,751 for those never started on it.",
"url": "https://www.coios.me/scottish-af-patients-never-started-on-anticoagulants-had/",
"published_at": "2026-10-03T13:10:56.000Z",
"updated_at": "2026-10-18T12:16:32.000Z",
"domain": "Health today",
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1007/s10198-026-01988-3",
"source": "The European Journal of Health Economics, 30 September 2026",
"paper_title": "Inequalities in oral anticoagulant treatment patterns: a two-part model to estimate healthcare costs associated with atrial fibrillation",
"authors": "Ciminata G, Mulholland RJ, Quinn TJ, Pollock KG, Geue C",
"doi": "10.1007/s10198-026-01988-3",
"type": "Peer-reviewed article",
"design": "Retrospective linked-records cohort, 47,427 incident AF patients, Scotland 2010-2016, five-year follow-up, IPTW two-part cost model",
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},
{
"kind": "item",
"title": "Weight loss in impaired glucose tolerance went with fewer deaths over 34 years",
"excerpt": "In 540 Chinese adults with impaired glucose tolerance, a weight loss of 5% or more over six years carried a hazard ratio for death of 0.67 against no weight loss.",
"url": "https://www.coios.me/weight-loss-after-a-prediabetes-diagnosis-tracked-lower/",
"published_at": "2026-10-03T13:10:45.000Z",
"updated_at": "2026-10-18T12:16:32.000Z",
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"China"
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"country_codes": [
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.2337/dc26-0689",
"source": "Diabetes Care, 1 October 2026",
"paper_title": "Early Weight Loss in Impaired Glucose Tolerance Is Associated With Reduced Long-term Mortality and Cardiovascular Risk: The Da Qing Diabetes Prevention Outcome Study",
"authors": "He S, Yu L, Wang J, Qian X, Yang Z, Feng X et al.",
"doi": "10.2337/dc26-0689",
"type": "Peer-reviewed article",
"design": "Post hoc analysis of the Da Qing Diabetes Prevention Study: 540 Chinese adults with impaired glucose tolerance grouped by weight change over the 6-year intervention, followed 34 years",
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},
{
"kind": "item",
"title": "Systolic pressure was 5.8 mmHg lower with apps and wearables after stroke",
"excerpt": "Across 29 studies in 8,389 stroke and transient ischaemic attack survivors, systolic blood pressure was 5.8 mmHg lower with mobile applications or wearables, though prediction intervals crossed the null.",
"url": "https://www.coios.me/digital-interventions-after-stroke-were-linked-to-5-8-mmhg/",
"published_at": "2026-10-03T13:10:32.000Z",
"updated_at": "2026-10-18T12:16:32.000Z",
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"country_codes": [
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1212/cpj.0000000000200669",
"source": "Neurology Clinical Practice, 1 October 2026",
"paper_title": "Digital Health Technologies for Risk Factor Management and Secondary Prevention After Stroke: A Systematic Review and Meta-Analysis",
"authors": "Badihian S, Fedorova M, Ong BA, Thompson NR, Nero N, Uchino K et al.",
"doi": "10.1212/cpj.0000000000200669",
"type": "Peer-reviewed article",
"design": "Systematic review and random-effects meta-analysis of 29 randomised, single-arm and observational studies, 8,389 stroke or TIA survivors, searched to September 2025",
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{
"kind": "item",
"title": "A blood protein score of cellular ageing predicted death in UK Biobank",
"excerpt": "A blood protein score of cellular ageing, built in UK Biobank, predicted death and later dementia, COPD, heart attack and stroke, and changed over 18 months with exercise.",
"url": "https://www.coios.me/a-deep-learning-senescence-proteomic-score-predicted/",
"published_at": "2026-10-03T13:10:29.000Z",
"updated_at": "2026-10-21T06:05:47.000Z",
"domain": "Data, models and systems",
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"source_url": "https://doi.org/10.1111/acel.70737",
"source": "Aging Cell, 1 October 2026",
"paper_title": "A Deep-Learning Based Biomarker of Systemic Cellular Senescence Burden to Predict Mortality and Health Outcomes",
"authors": "Zhao S, Kuo CL, Lenze EJ, Wetherell JL, Haynes L, El-Ahmad P et al.",
"doi": "10.1111/acel.70737",
"type": "Peer-reviewed article",
"design": "Semi-supervised deep-learning (guided autoencoder with transformer) proteomic score developed in UK Biobank Pharma Proteomics Project, externally validated in an independent randomised trial cohort with 18-month follow-up",
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"attention": "1 citation (Crossref) · as of 2026-10-21",
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},
{
"kind": "item",
"title": "Fewer than one in five US stroke and TIA patients filled a P2Y12 inhibitor",
"excerpt": "Among 45,763 US adults with a first ischaemic stroke or TIA, 18.9% filled a P2Y12 inhibitor within 30 days, and half of clopidogrel initiators had stopped filling by 180 days.",
"url": "https://www.coios.me/half-of-clopidogrel-initiators-after-stroke-stopped-filling/",
"published_at": "2026-10-03T13:08:32.000Z",
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1177/10600280261487728",
"source": "Annals of Pharmacotherapy, 1 October 2026",
"paper_title": "Real-World Postdischarge P2Y12 Inhibitor Use After Ischemic Stroke and Transient Ischemic Attack, 2020 to 2024",
"authors": "Qureshi AI, Raza H, Tolba H, Kaur G, Pfeiffer K, Sandifer T et al.",
"doi": "10.1177/10600280261487728",
"type": "Peer-reviewed article",
"design": "Retrospective descriptive cohort, US claims 2020-2025, 45 763 adults with first ischaemic stroke or TIA; persistence assessed in 5641 continuously enrolled initiators",
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"kind": "item",
"title": "Adult mortality is 26% higher for those whose fathers held lower-ranked jobs",
"excerpt": "A meta-analysis of 102 cohort studies covering about 8.5 million people in 24 countries found adult all-cause mortality 26% higher for those whose fathers held lower-ranked occupations.",
"url": "https://www.coios.me/childhood-disadvantage-carried-a-26-higher-rate-of-adult/",
"published_at": "2026-10-03T13:08:18.000Z",
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"source_url": "https://doi.org/10.1016/s2468-2667(26)00187-8",
"source": "The Lancet Public Health, 1 October 2026",
"paper_title": "Childhood socioeconomic circumstances and adult mortality: a systematic review and meta-analysis",
"authors": "Broadbent P, Carr A, Igelström E, Calderon M, Hainey K, Campbell M et al.",
"doi": "10.1016/s2468-2667(26)00187-8",
"type": "Peer-reviewed article",
"design": "Systematic review and meta-analysis of 102 observational cohort studies, ~8.5 million participants, 24 countries, searched to May 2026",
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{
"kind": "item",
"title": "Tirzepatide initiators stayed on treatment longer than semaglutide initiators",
"excerpt": "In propensity-matched US claims data on adults with type 2 diabetes, 12-month adherence was 60% for tirzepatide initiators against 45% for semaglutide initiators among GLP-1-naive patients, with persistence of 62% against 47%.",
"url": "https://www.coios.me/tirzepatide-initiators-stayed-on-treatment-longer-than/",
"published_at": "2026-10-03T13:05:59.000Z",
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.18553/jmcp.2026.32.10.1173",
"source": "Journal of Managed Care & Specialty Pharmacy, 1 October 2026",
"paper_title": "Real-world treatment patterns and cost per patient achieving treatment targets among tirzepatide and semaglutide initiators in US patients with type 2 diabetes",
"authors": "Hoog MM, Vallarino C, Maldonado JM, Grabner M, Teng CC, Terrell K et al.",
"doi": "10.18553/jmcp.2026.32.10.1173",
"type": "Peer-reviewed article",
"design": "Retrospective propensity-matched claims and laboratory cohort, 10,702 GLP-1-naive and 5,577 non-naive pairs, initiation May 2022-May 2023, 12 months' follow-up",
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{
"kind": "item",
"title": "Proteomic organ clocks tracked 16-year mortality less closely than epigenetic age",
"excerpt": "Accelerated liver, immune and heart proteomic ageing carried hazard ratios of 1.38 to 1.43 per standard deviation for 16-year mortality, below those for epigenetic age and cognition.",
"url": "https://www.coios.me/proteomic-organ-clocks-tracked-16-year-mortality-slightly/",
"published_at": "2026-10-03T13:05:12.000Z",
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"source_url": "https://doi.org/10.1111/acel.70747",
"source": "Aging Cell, 1 October 2026",
"paper_title": "Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated With All-Cause Mortality",
"authors": "Pyrgioti M, Eguiagaray IM, Redmond P, Corley J, Bastin ME, Hernández MV et al.",
"doi": "10.1111/acel.70747",
"type": "Peer-reviewed article",
"design": "Prospective cohort, Lothian Birth Cohort 1936, 861 participants, 444 deaths over 16 years; Cox regression benchmarking of ageing biomarkers and 9703 plasma protein targets",
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"title": "GLP-1 prescribing to US children aged 8-11 with obesity rose but stayed under 1%",
"excerpt": "Among 3.5 million US children aged 8 to 11 with obesity and without diabetes recorded in Epic Cosmos between 2019 and June 2026, 0.6% received a GLP-1 receptor agonist prescription, with rates highest among 11-year-olds, girls, and those with obesity-related comorbidities.",
"url": "https://www.coios.me/glp-1-prescribing-to-us-children-aged-8-11-with-obesity/",
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"source_url": "https://doi.org/10.1542/peds.2026-077048",
"source": "Pediatrics, 1 October 2026",
"paper_title": "Trends in GLP-1 Receptor Agonist Prescriptions for Children Ages 8 to 11 With Obesity: 2019-2026",
"authors": "Orandi BJ, Patel SS, Messito MJ, Mankowski MA, Segev DL, Massie AB",
"doi": "10.1542/peds.2026-077048",
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"kind": "item",
"title": "Daily cancer deaths in Japan were 0.88% higher per 10 micrograms/m3 of PM2.5",
"excerpt": "A 10 microgram per cubic metre rise in PM2.5 was associated with 0.88% more cancer deaths in Japan, though the association did not survive adjustment for NO2 or SO2.",
"url": "https://www.coios.me/daily-cancer-deaths-in-japan-rose-0-88-per-10-micrograms/",
"published_at": "2026-10-03T13:00:50.000Z",
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"jp"
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"source_url": "https://doi.org/10.1002/ijc.70761",
"source": "International Journal of Cancer, 30 September 2026",
"paper_title": "Short-Term PM2.5 Exposure and Daily Cancer Mortality Across 47 Japanese Prefectures: A Nationwide Time-Stratified Case-Crossover Study, 2013-2022",
"authors": "Gyeltshen T, Abubakar AK, Jamil H, Suzuki T, Babu H, Nguyen PT",
"doi": "10.1002/ijc.70761",
"type": "Peer-reviewed article",
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{
"kind": "item",
"title": "Language models identified overdose deaths from New York investigators' written reports",
"excerpt": "Reading the reports New York City death investigators write on each case, the better of two language models identified suspected overdose deaths with 92% sensitivity and 88% positive predictive value.",
"url": "https://www.coios.me/an-llm-identified-nyc-overdose-deaths-from-investigator/",
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"United States"
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"us"
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"verdict": "new",
"source_url": "https://doi.org/10.2105/ajph.2026.308698",
"source": "American journal of public health, 1 October 2026",
"paper_title": "Human-Centered Artificial Intelligence Framework for Overdose Mortality Surveillance, New York City, 2022‒2023",
"authors": "Hochstatter KR, Nadel T, Gupta R, Jangra A, D'Anna N, Gryczynski J et al.",
"doi": "10.2105/ajph.2026.308698",
"type": "Peer-reviewed article",
"design": "Model development and internal evaluation on 9,263 narrative death investigation reports, New York City OCME, 2022–2023, two LLM families against the incumbent tool and logistic regression",
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{
"kind": "item",
"title": "Modelled depression screening of KwaZulu-Natal sex workers averts HIV at $490 per QALY",
"excerpt": "A transmission model for KwaZulu-Natal found depression screening with behavioural treatment most cost-effective among female sex workers, at $350 per HIV infection averted and $490 per QALY gained.",
"url": "https://www.coios.me/modelled-depression-screening-in-kwazulu-natal-averted-hiv/",
"published_at": "2026-10-03T13:00:21.000Z",
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"countries": [
"South Africa"
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"za"
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"verdict": "new",
"source_url": "https://doi.org/10.1097/qai.0000000000003920",
"source": "JAIDS Journal of Acquired Immune Deficiency Syndromes, 1 October 2026",
"paper_title": "Cost-Effectiveness of Reducing HIV Infections Through Screening and Treating Alcohol Use and Depression in KwaZulu-Natal, South Africa: A Mathematical Modeling Study",
"authors": "Jeetoo M, Yeo YR, Charles DL, Moll AP, Shenoi SV, Morojele NK et al.",
"doi": "10.1097/qai.0000000000003920",
"type": "Peer-reviewed article",
"design": "HIV compartmental transmission model with cost-utility analysis, KwaZulu-Natal, horizon to 2030",
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"kind": "item",
"title": "One in nine older US cannabis users meets criteria for cannabis use disorder",
"excerpt": "In a national US survey, 8.9% of adults aged 65 and over had used cannabis in the past year, and 11.4% of those met criteria for cannabis use disorder.",
"url": "https://www.coios.me/one-in-nine-older-us-cannabis-users-meets-criteria-for/",
"published_at": "2026-09-30T07:12:10.000Z",
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"us"
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"verdict": "new",
"source_url": "https://doi.org/10.1111/add.70600",
"source": "Addiction, 28 September 2026",
"paper_title": "Cannabis use and cannabis use disorder among older adults in the USA",
"authors": "Han BH, Eschliman EL, Palamar JJ, Triguero Roura M, Mauro PM",
"doi": "10.1111/add.70600",
"type": "Peer-reviewed article",
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{
"kind": "item",
"title": "Uncertainty in a biological age estimate is itself associated with mortality",
"excerpt": "In over 450,000 UK Biobank participants, the uncertainty of a biological age estimate was associated with mortality, multimorbidity and loss of healthspan independently of the age gap itself.",
"url": "https://www.coios.me/uncertainty-in-a-biological-age-estimate-predicts-mortality/",
"published_at": "2026-09-30T07:07:48.000Z",
"updated_at": "2026-10-18T12:16:34.000Z",
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"United Kingdom"
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"gb"
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"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.09.26.26364091",
"source": "medRxiv, 28 September 2026",
"paper_title": "Uncertainty redefines biological age",
"authors": "Li Y, Feng G, Yan S, Huang Q, Jiang J, Pei Z et al.",
"doi": "10.64898/2026.09.26.26364091",
"type": "Preprint",
"design": "Probabilistic biological-age modelling in 450,000+ UK Biobank participants with NMR, proteomic and routine-blood panels, prospective mortality and healthspan follow-up, GWAS, and replication in three external cohorts",
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},
{
"kind": "item",
"title": "Modelled hepatitis B cure is cost-effective under USD46,642 a course in the US",
"excerpt": "A Markov model estimated that a hepatitis B cure regimen working in 30% of patients would be cost-effective at a one-off price below USD46,642 in the US.",
"url": "https://www.coios.me/hepatitis-b-cure-at-30-efficacy-modelled-as-cost-effective/",
"published_at": "2026-09-30T07:03:39.000Z",
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"China"
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"us",
"cn"
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"verdict": "new",
"source_url": "https://doi.org/10.14309/ctg.0000000000001108",
"source": "Clinical and Translational Gastroenterology, 28 September 2026",
"paper_title": "A Markov model cost threshold analysis of potential hepatitis B virus cure regimens",
"authors": "Wong GL, Wong RJ, Yang B, Wong VW, Lai JC, Chan HL et al.",
"doi": "10.14309/ctg.0000000000001108",
"type": "Peer-reviewed article",
"design": "Markov state-transition cost-utility model, base case 50-year-old HBeAg-negative non-cirrhotic man on suppressive NUC, US and China cost perspectives",
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},
{
"kind": "item",
"title": "Electronic death notification in Zambia lifted completeness from 11.9% to 17.4%",
"excerpt": "An electronic version of Zambia's death notification form, used in burial offices across four provinces, cut the mean reporting delay from six days to three.",
"url": "https://www.coios.me/zambia-s-mobile-death-notification-lifted-registration/",
"published_at": "2026-09-30T07:03:27.000Z",
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"verdict": "new",
"source_url": "https://doi.org/10.1080/16549716.2026.2732479",
"source": "Global Health Action, 28 September 2026",
"paper_title": "Digitizing death reporting in Zambia: evaluation of a mobile-based civil registration system",
"authors": "Odhiambo CO, Katama EN, Munkombwe B, Mwango C, Moyo S, Mapoma CC",
"doi": "10.1080/16549716.2026.2732479",
"type": "Peer-reviewed article",
"design": "Implementation case study of electronic Form 13 in burial offices in four Zambian provinces; 115,573 deaths captured over six months, covering deaths occurring January 2021 to June 2025",
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},
{
"kind": "item",
"title": "Oral GLP-1 tablet safiglipron cut HbA1c by up to 1.45 points in type 2 diabetes",
"excerpt": "In the OUTSTAND-1 trial, once-daily safiglipron tablets lowered HbA1c by up to 1.45 percentage points more than placebo over 32 weeks in untreated type 2 diabetes.",
"url": "https://www.coios.me/oral-glp-1-agonist-safiglipron-cut-hba1c-by-up-to-1-45/",
"published_at": "2026-09-30T06:59:35.000Z",
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"source_url": "https://www.nature.com/articles/s41591-026-04651-9",
"source": "Nature Medicine, 29 September 2026",
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"design": "Randomised, double-blind, placebo-controlled trial (OUTSTAND-1), 32 weeks, in people with type 2 diabetes not on glucose-lowering medication; sample size not stated",
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},
{
"kind": "item",
"title": "Loneliness predicts psychological distress better than other social measures",
"excerpt": "In a 29-country European survey of 48,377 respondents, loneliness was the strongest social predictor of psychological distress, and the other social measures together added 0.006 to the AUC.",
"url": "https://www.coios.me/loneliness-carries-most-of-the-social-signal-for/",
"published_at": "2026-09-30T06:59:11.000Z",
"updated_at": "2026-10-18T12:16:35.000Z",
"domain": "Behavioural science",
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"eu",
"us"
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"source_type": "peer-reviewed",
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"source_url": "https://doi.org/10.1177/00207640261487612",
"source": "International Journal of Social Psychiatry, 28 September 2026",
"paper_title": "Loneliness as a Benchmark Social-connection Signal for Psychological Distress: Cross-national, Longitudinal and Genetically Informed Triangulation Evidence",
"authors": "Yang F",
"doi": "10.1177/00207640261487612",
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},
{
"kind": "item",
"title": "APOE e4 dementia risk is largest in European ancestry across 367,757 US adults",
"excerpt": "A study of APOE genotype against 2,632 traits and conditions in 367,757 All of Us participants found 27 associations, with dementia risk largest in those of European ancestry.",
"url": "https://www.coios.me/apoe-e4-dementia-and-liver-associations-differ-by-ancestry/",
"published_at": "2026-09-30T06:55:21.000Z",
"updated_at": "2026-10-18T12:16:35.000Z",
"domain": "Health today",
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"us"
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"source_type": "preprint",
"verdict": "refines",
"source_url": "https://doi.org/10.64898/2026.09.26.26364080",
"source": "medRxiv, 28 September 2026",
"paper_title": "Phenome-wide and proteomic analysis of APOE alleles across different ancestries in the All of Us Research Program",
"authors": "Mejia-Garcia A, Valderrama-Carmona P, Zheng TM, Wang Z, Tsao HM, Jung J et al.",
"doi": "10.64898/2026.09.26.26364080",
"type": "Preprint",
"design": "Phenome-wide association study of APOE genotype against 2,632 phenotypes in 367,757 All of Us participants across six ancestry groups, with plasma proteomics in 9,132",
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},
{
"kind": "item",
"title": "Modelling puts maternal deaths 68,489 above pre-pandemic trends over 2020 to 2023",
"excerpt": "Models fitted to WHO/UN estimates for 2000 to 2019 put maternal deaths for 2020 to 2023 at 68,489 above the projected path, with excess detectable in 113 of 195 countries.",
"url": "https://www.coios.me/modelled-excess-maternal-deaths-of-68-489-in-2020-2023-with/",
"published_at": "2026-09-30T06:55:06.000Z",
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"countries": [
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"source_type": "preprint",
"verdict": "refines",
"source_url": "https://doi.org/10.64898/2026.06.30.26356947",
"source": "medRxiv, 28 September 2026",
"paper_title": "Global Excess Maternal Mortality During the COVID-19 Pandemic: Country-Level Counterfactual Estimates and Associated Factors",
"authors": "Gajjar JH, Karami H, Hayes HA, Dixon MA, Massetti GM, Chowell G",
"doi": "10.64898/2026.06.30.26356947",
"type": "Preprint",
"design": "Counterfactual modelling of WHO/UN MMEIG maternal mortality estimates, 195 countries, 2000-2019 fitted and projected to 2020-2023; regression on service disruption in 39 countries (63 country-years)",
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{
"kind": "item",
"title": "Between 15% and 49% of heart disease patients had clinically elevated cardiac anxiety",
"excerpt": "A review of 26 studies in 9,628 patients with cardiovascular disease found clinically elevated fear of cardiac sensations in 15% to 49%, varying with the questionnaire cut-off used.",
"url": "https://www.coios.me/heart-focused-anxiety-was-clinically-elevated-in-15-to-49/",
"published_at": "2026-09-30T06:50:50.000Z",
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1093/eurjpc/zwag509",
"source": "European Journal of Preventive Cardiology, 28 September 2026",
"paper_title": "Cardiac Anxiety in Adults with Cardiovascular Disease: Prevalence, Predictors, and Implications for Cardiac Rehabilitation - A Systematic Review",
"authors": "Nwankwo HE, Ogunniyi KE, Okezue C, Divine D, Adebisi YA, Balogun T et al.",
"doi": "10.1093/eurjpc/zwag509",
"type": "Peer-reviewed article",
"design": "Systematic review with narrative synthesis, 26 studies, 9,628 enrolled patients across eight countries",
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{
"kind": "item",
"title": "Carers who repeatedly stop and restart unpaid care are more likely to smoke",
"excerpt": "In the UK Household Longitudinal Study, adults repeatedly moving in and out of unpaid caring had higher odds of smoking (OR 1.67) and lower odds of physical inactivity (OR 0.65).",
"url": "https://www.coios.me/recurrent-unpaid-caregiving-was-linked-to-higher-smoking/",
"published_at": "2026-09-30T06:47:02.000Z",
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"domain": "Behavioural science",
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"source_type": "preprint",
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"source_url": "https://doi.org/10.64898/2026.09.26.26364079",
"source": "medRxiv, 28 September 2026",
"paper_title": "Caregiving transition trajectories and health behaviours: a latent class analysis of the UK Household Longitudinal Study",
"authors": "Pfeifer E, Lacey RE, Xue B, Pikhart H, McMunn A",
"doi": "10.64898/2026.09.26.26364079",
"type": "Preprint",
"design": "Latent class analysis of 12 waves of UK Household Longitudinal Study, n=25,049, 2010-2023",
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{
"kind": "item",
"title": "Lower education was the most consistent marker of obesity in Korean adults",
"excerpt": "Analysis of Korea's national health and nutrition survey for 2022 to 2024 found lower education the most consistent marker of obesity in adults, with income and employment less consistent.",
"url": "https://www.coios.me/lower-education-was-the-most-consistent-socioeconomic/",
"published_at": "2026-09-30T06:42:47.000Z",
"updated_at": "2026-10-18T12:16:36.000Z",
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.23889/ijpds.v11i3.3430",
"source": "International Journal of Population Data Science, 29 September 2026",
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"source": "International journal of addiction nursing, 28 September 2026",
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"paper_title": "In-Hospital Mortality Trends Among Hospitalized Adults With Cardiac Arrest, 2016-2022",
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"paper_title": "Validating Artificial Intelligence Guidance for Ultrasound Acquisition and Remote Interpretation",
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"paper_title": "Behavioral profiles associated with adherence to adjuvant endocrine therapy in breast cancer: a retrospective population-based cohort study",
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{
"kind": "item",
"title": "28% of middle-aged and older Canadians know of the hearing loss-dementia link",
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"source_url": "https://doi.org/10.64898/2026.01.12.26343953",
"source": "medRxiv, 26 September 2026",
"paper_title": "Public awareness of the hearing loss-dementia link and self-reported behavioral changes in middle- to older-aged Canadians",
"authors": "Bobbitt S, Mathiesen SL, Binns M, Herrmann B",
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"title": "Myelosuppression is gemcitabine's most consistent signal in FDA adverse event reports",
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"url": "https://www.coios.me/gemcitabine-regimens-show-consistent-myelosuppression/",
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"source_url": "https://doi.org/10.64898/2026.09.24.26363686",
"source": "medRxiv, 27 September 2026",
"paper_title": "Reporting Odds Ratio Analysis of Gemcitabine-Based Chemotherapy Regimens for Biliary and Pancreatic Cancer: Population-Level Toxicity Signals and Hypotheses for High-Altitude Generalizability",
"authors": "Dang Z, Dan J, Li S, Yanan L, Su W, Ren G et al.",
"doi": "10.64898/2026.09.24.26363686",
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"kind": "item",
"title": "Scottish drug deaths rose 11% in 2025, with nitazenes linked to a fifth of fatalities",
"excerpt": "Drug-related deaths in Scotland rose by 11% to 1133 in 2025, with 247 (22%) linked to nitazenes, more than triple the 2024 figure, although routine postmortem testing for etonitazene began only in May 2025.",
"url": "https://www.coios.me/scottish-drug-deaths-rose-11-in-2025-with-nitazenes-linked/",
"published_at": "2026-09-27T09:21:04.000Z",
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"verdict": "refines",
"source_url": "http://www.bmj.com/content/394/bmj-2026-100969.short?rss=1",
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{
"kind": "item",
"title": "G6PD-guided primaquine package costs US$6,636 per DALY averted in Indonesia",
"excerpt": "A decision-tree model of G6PD screening with high-dose primaquine for Plasmodium vivax in Indonesia gave US$6,636 per DALY averted, above the willingness-to-pay threshold of one GDP per capita.",
"url": "https://www.coios.me/safe-7-day-primaquine-package-costs-us-6-636-per-daly/",
"published_at": "2026-09-27T09:01:18.000Z",
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"source_url": "https://doi.org/10.64898/2026.09.23.26363845",
"source": "medRxiv, 25 September 2026",
"paper_title": "Cost-effectiveness of a package to ensure safe prescription of 7-day high-dose primaquine for the radical cure of Plasmodium vivax in Indonesia",
"authors": "Abraham P, Fransisca L, Adella J, Rahmalia A, Jimanto V, Angeline S et al.",
"doi": "10.64898/2026.09.23.26363845",
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"kind": "item",
"title": "UK database lists the additives that mark a food as ultra-processed",
"excerpt": "Researchers have sorted every additive approved in the UK by its purpose, so that those used to alter taste, colour or texture mark a product as ultra-processed.",
"url": "https://www.coios.me/a-uk-database-of-ultra-processing-markers-is-released-for/",
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"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.09.24.26363859",
"source": "medRxiv, 25 September 2026",
"paper_title": "Development of a comprehensive database of markers of ultra-processing to identify ultra-processed food in the UK according to the Nova classification",
"authors": "Dicken SJ, van Tulleken D",
"doi": "10.64898/2026.09.24.26363859",
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{
"kind": "item",
"title": "Modelled summer COVID-19 vaccination averts more US hospitalisations in over-65s",
"excerpt": "A US transmission model estimated 441 COVID-19 hospitalisations per 100,000 adults aged 65 and over under July vaccination, as compared to 578 with no further vaccination.",
"url": "https://www.coios.me/modelled-july-covid-vaccination-averts-most/",
"published_at": "2026-09-27T08:54:58.000Z",
"updated_at": "2026-10-18T12:16:39.000Z",
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"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.09.23.26363810",
"source": "medRxiv, 25 September 2026",
"paper_title": "Rethinking seasonal COVID-19 vaccination in the endemic era: summer timing, eligibility, and frequency in the United States",
"authors": "Bubar KM, Park HJ, Bents SJ, Tan ST, Singer BJ, Kelly JD et al.",
"doi": "10.64898/2026.09.23.26363810",
"type": "Preprint",
"design": "Stochastic individual-based SARS-CoV-2 transmission model, 5 million simulated US residents, calibrated to hospitalisation incidence May 2024-April 2025",
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{
"kind": "item",
"title": "Older adults walked 483 fewer steps after a day of higher fine particle exposure",
"excerpt": "In 67 UK adults aged 50-85, a day on which fine particle exposure ran 2.6 micrograms per cubic metre above the person's own average was followed by 483 fewer steps.",
"url": "https://www.coios.me/higher-than-usual-personal-particulate-exposure-precedes/",
"published_at": "2026-09-27T08:51:07.000Z",
"updated_at": "2026-10-18T12:16:39.000Z",
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"verdict": "refines",
"source_url": "https://doi.org/10.64898/2026.09.23.26363783",
"source": "medRxiv, 25 September 2026",
"paper_title": "Associations of individual exposure to particulate matter with next-day physical activity and sedentary behaviour in older adults: a micro-longitudinal study",
"authors": "Bloomberg M, Jones M, Brocklebank L, Zaninotto P, Steptoe A",
"doi": "10.64898/2026.09.23.26363783",
"type": "Preprint",
"design": "Micro-longitudinal study, 67 UK adults aged 50-85, 304 person-days, paired personal air quality monitors and 24-hour accelerometry over five days",
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},
{
"kind": "item",
"title": "Blood-based multicancer screening did not reduce late-stage cancer in 142,250 adults",
"excerpt": "In the NHS-Galleri trial of 142,250 adults in England, three annual rounds of multicancer early-detection testing did not reduce stage III or IV cancer incidence (rate ratio 1.03).",
"url": "https://www.coios.me/a-multicancer-blood-test-did-not-cut-late-stage-cancer/",
"published_at": "2026-09-26T09:54:53.000Z",
"updated_at": "2026-10-22T06:05:28.000Z",
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"source_url": "https://doi.org/10.1056/nejmoa2505723",
"source": "New England Journal of Medicine, 22 September 2026",
"paper_title": "Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis",
"authors": "Sasieni P, Johnson P, Round T, Warwick J, Jones H, Dolly S et al.",
"doi": "10.1056/nejmoa2505723",
"type": "Peer-reviewed article",
"design": "Randomised controlled trial, 142,250 adults aged 50-77 in England, three annual screening rounds plus at least 12 months' follow-up",
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"attention": "5 citations (Crossref) · as of 2026-10-22",
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},
{
"kind": "item",
"title": "England's linked child health and school records miss deprived and minoritised children",
"excerpt": "ECHILD, which links hospital, school and social care records for 21 million children in England, includes children in deprived areas and in minoritised ethnic groups less often than others.",
"url": "https://www.coios.me/england-s-echild-linkage-under-covers-deprived-and/",
"published_at": "2026-09-26T09:47:10.000Z",
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"source_url": "https://doi.org/10.64898/2026.09.16.26363127",
"source": "medRxiv, 22 September 2026",
"paper_title": "Evaluation of linkage between health, education and social care administrative data for 21 million children in England",
"authors": "Nguyen V, Lam J, Stone T, Blackburn R, Gilbert R, Ruiz Nishiki M et al.",
"doi": "10.64898/2026.09.16.26363127",
"type": "Preprint",
"design": "Linkage-quality evaluation of four birth and school cohorts within the ECHILD health–education–social care linkage, England, births Sep 1984–Mar 2023 (21.3m linked individuals)",
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{
"kind": "item",
"title": "Korea's 2025-26 avian flu outbreaks included an H5N1 genotype from Europe",
"excerpt": "Sequencing of H5Nx viruses from 62 poultry outbreaks and 63 wild bird cases in Korea found most H5N1 and H5N9 genotypes were reassortants, one of them a genotype from Europe.",
"url": "https://www.coios.me/korea-s-2025-26-avian-flu-season-carried-diverse-h5nx/",
"published_at": "2026-09-26T09:36:23.000Z",
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1016/j.virusres.2026.199807",
"source": "Virus Research, 22 September 2026",
"paper_title": "Genetic Diversity of Clade 2.3.4.4b H5Nx High Pathogenicity Avian Influenza Viruses Detected in Korea During the 2025-2026 Winter Season and Pathogenicity of H5N1 and H5N9 Viruses",
"authors": "Jang Y, Cha RM, Park MJ, Kim JM, Lim EH, Heo GB et al.",
"doi": "10.1016/j.virusres.2026.199807",
"type": "Peer-reviewed article",
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{
"kind": "item",
"title": "Australian MDMA-related poisoning deaths rose to 2019 and then fell to 2023",
"excerpt": "A coronial series of 217 MDMA-related fatal poisonings in Australia found the population rate rising to 2019 and falling to 2023, with other psychoactive drugs detected in 91.7% of cases.",
"url": "https://www.coios.me/mdma-related-fatal-poisonings-in-australia-rose-to-2019/",
"published_at": "2026-09-26T09:36:20.000Z",
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1111/add.70613",
"source": "Addiction, 21 September 2026",
"paper_title": "Methylenedioxymethamphetamine (MDMA)-related fatal poisoning in Australia, 2016 to 2025: Trends, characteristics and toxicology",
"authors": "Darke S, Duflou J, Chrzanowska A, Farrell M, Lappin J, Peacock A",
"doi": "10.1111/add.70613",
"type": "Peer-reviewed article",
"design": "Retrospective national coronial case series, 217 MDMA-related fatal poisonings, Australia 2016-2025, with population rates 2016-2023",
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{
"kind": "item",
"title": "Unemployed and unmarried Danes start cardioprotective diabetes drugs less often",
"excerpt": "Among 81,361 Danes with type 2 diabetes and cardiovascular disease, unemployed men started cardioprotective glucose-lowering drugs at 0.77 times the rate of employed men, and unemployed women 0.81 times.",
"url": "https://www.coios.me/unemployed-and-unmarried-danes-start-cardioprotective/",
"published_at": "2026-09-26T09:36:17.000Z",
"updated_at": "2026-10-18T12:16:40.000Z",
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"countries": [
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1111/dom.71334",
"source": "Diabetes, Obesity and Metabolism, 20 September 2026",
"paper_title": "Sex and Socioeconomic Differences in the Initiation of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Patients With Type 2 Diabetes and Cardiovascular Disease: A Nationwide Cohort Study",
"authors": "Calderon E, Bjerg L, Isaksen AA, Sandbæk A, Funck KL, Grove EL",
"doi": "10.1111/dom.71334",
"type": "Peer-reviewed article",
"design": "Danish nationwide registry cohort, 81,361 adults with new concurrent type 2 diabetes and cardiovascular disease, 2015-2022",
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"kind": "item",
"title": "Photo review found compounded products in a quarter of surveyed US GLP-1 users",
"excerpt": "Blinded review of medication photographs classified 25.8% of 322 US adults on weekly semaglutide or tirzepatide as using compounded products, with self-report agreeing for 82.6%.",
"url": "https://www.coios.me/photo-checks-put-a-quarter-of-surveyed-us-glp-1-users-on/",
"published_at": "2026-09-26T09:35:02.000Z",
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"verdict": "new",
"source_url": "https://doi.org/10.1002/osp4.70200",
"source": "Obesity Science & Practice, 22 September 2026",
"paper_title": "Improving Medication Classification in GLP-1RA Research: Feasibility of a Photo-Review Protocol",
"authors": "Katz JM, Gearhardt AN, Griauzde DH",
"doi": "10.1002/osp4.70200",
"type": "Peer-reviewed article",
"design": "Online survey with blinded photo validation of medication, US adults on weekly semaglutide or tirzepatide ≥3 months, n=322 analytic sample",
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{
"kind": "item",
"title": "Door-to-balloon under 60 minutes linked to lower mortality only in higher-risk STEMI",
"excerpt": "Among 4,513 STEMI patients in China, a door-to-balloon time over 60 minutes carried 1.69x the three-year mortality in those at higher risk on admission, but no difference at lower risk.",
"url": "https://www.coios.me/faster-door-to-balloon-time-tracks-lower-stemi-mortality/",
"published_at": "2026-09-26T09:33:18.000Z",
"updated_at": "2026-10-18T12:16:41.000Z",
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"country_codes": [
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"source_url": "https://doi.org/10.1136/bmjopen-2026-120981",
"source": "BMJ Open, 22 September 2026",
"paper_title": "Association between door-to-balloon time ≤60 minutes and short- and long-term outcomes in patients with ST-segment elevation myocardial infarction: a retrospective cohort study",
"authors": "Wang Z, Wang Z, Zhi X, Kang Z, Liu Y, Xu K et al.",
"doi": "10.1136/bmjopen-2026-120981",
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"kind": "item",
"title": "Walking speed predicts survival at ages 90-94, but not beyond",
"excerpt": "Among 502 adults aged 90 and over, each 0.21 m/s of faster walking speed was associated with 20% lower mortality, although the association was absent beyond age 95.",
"url": "https://www.coios.me/gait-speed-predicted-mortality-at-ages-90-94-but-not-at-95/",
"published_at": "2026-09-26T09:32:42.000Z",
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"Frailty and multimorbidity"
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"United States"
],
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"us"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1111/jgs.70716",
"source": "Journal of the American Geriatrics Society, 21 September 2026",
"paper_title": "Gait Speed and Survival in Those With Exceptional Longevity: The LifeAfter90 Study",
"authors": "Alam R, Colbeth HL, Posis AIB, George KM, Colcord K, Meunier CC et al.",
"doi": "10.1111/jgs.70716",
"type": "Peer-reviewed article",
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},
{
"kind": "item",
"title": "Pacemakers after cardiac surgery carry higher later death and heart failure risk",
"excerpt": "Among 76 223 Swedish adults having cardiac surgery, the 2.8% given a pacemaker within 30 days had a higher adjusted risk of death and of heart failure admission over 6.8 years.",
"url": "https://www.coios.me/pacemaker-after-cardiac-surgery-carries-modestly-higher/",
"published_at": "2026-09-26T09:32:00.000Z",
"updated_at": "2026-10-18T12:16:41.000Z",
"domain": "Tomorrow's world",
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"Sweden"
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"se"
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"source_type": "peer-reviewed",
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"source_url": "https://doi.org/10.1136/heartjnl-2026-328361",
"source": "Heart, 21 September 2026",
"paper_title": "Permanent pacemaker implantation after cardiac surgery and long-term outcome",
"authors": "David LA, Taha A, Thorleifsson S, Smith JG, Jeppsson A, Martinsson A",
"doi": "10.1136/heartjnl-2026-328361",
"type": "Peer-reviewed article",
"design": "Nationwide Swedish registry cohort, 76 223 adults undergoing cardiac surgery 2006-2020, mean follow-up 6.8 years, Cox models",
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},
{
"kind": "item",
"title": "The most active mid-life adults in UK Biobank report more fractures",
"excerpt": "Among 322,749 UK Biobank participants in mid-life, fracture in the previous five years was more common in the most active fifth, but not in those meeting WHO recommendations.",
"url": "https://www.coios.me/high-volume-vigorous-exercise-in-mid-life-tracks-higher/",
"published_at": "2026-09-26T09:31:35.000Z",
"updated_at": "2026-10-18T12:16:41.000Z",
"domain": "Behavioural science",
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"United Kingdom"
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"source_type": "preprint",
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"source_url": "https://doi.org/10.64898/2026.07.27.26358989",
"source": "medRxiv, 22 September 2026",
"paper_title": "HOW SAFE IS EXERCISE? A CROSS-SECTIONAL ANALYSIS BETWEEN MID-LIFE PHYSICAL ACTIVITY AND FRACTURES IN UK BIOBANK",
"authors": "Rolls C, Tobias JH, Clark EM, Dawes H, Munafo M, Faber BG",
"doi": "10.64898/2026.07.27.26358989",
"type": "Preprint",
"design": "Cross-sectional analysis of 322,749 UK Biobank participants aged 40-65, self-reported activity and fracture in previous five years",
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"attention": "1 citation (Crossref) · as of 2026-10-16",
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},
{
"kind": "item",
"title": "Canada's missing measles vaccine coverage figures are filled in by modelling",
"excerpt": "Researchers curated publicly available Canadian vaccine coverage data and modelled first-dose measles coverage by province, territory and age, then tested the same method against England's more complete records.",
"url": "https://www.coios.me/gaussian-process-models-fill-gaps-in-canada-s-patchy/",
"published_at": "2026-09-26T09:31:07.000Z",
"updated_at": "2026-10-18T12:16:41.000Z",
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"Canada",
"United Kingdom"
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"ca",
"gb"
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"source_type": "preprint",
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"source_url": "https://doi.org/10.64898/2026.07.16.26358151",
"source": "medRxiv, 23 September 2026",
"paper_title": "Making inferences with incomplete epidemiological data: a proof-of-concept estimating measles vaccine coverage across Canada",
"authors": "Hadley L, Milwid R, Hongoh V, Wasfi R, Kissler SM, Papst I",
"doi": "10.64898/2026.07.16.26358151",
"type": "Preprint",
"design": "Methods preprint: Gaussian process imputation of measles vaccine coverage by province/territory and age, curated from public Canadian datasets, validated against English coverage data",
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},
{
"kind": "item",
"title": "GLP-1 agonists show no effect on atrial fibrillation in obese HFpEF patients",
"excerpt": "In 470 matched pairs of obese, non-diabetic patients with heart failure with preserved ejection fraction, GLP-1 receptor agonist treatment was not associated with lower atrial fibrillation incidence (HR 0.86, 95% CI 0.53-1.39), while all-cause mortality was lower (HR 0.42, 95% CI 0.23-0.75).",
"url": "https://www.coios.me/glp-1-agonists-show-no-effect-on-atrial-fibrillation-in/",
"published_at": "2026-09-26T09:27:30.000Z",
"updated_at": "2026-10-18T12:16:42.000Z",
"domain": "Health today",
"drivers": [
"Heart and stroke",
"Obesity, diabetes and GLP-1"
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"d-cardiovascular",
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"United States"
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"us"
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1002/joa3.70455",
"source": "Journal of Arrhythmia, 22 September 2026",
"paper_title": "Glucagon-Like Peptide-1 Agonists and the Incidence of Atrial Fibrillation in Obese Patients With Heart Failure With Preserved Ejection Fraction and No Diabetes",
"authors": "Rassam F, Lopez EK, Sass S, Srikulmontri T, Isaacs E, Malin J et al.",
"doi": "10.1002/joa3.70455",
"type": "Peer-reviewed article",
"design": "Propensity-matched retrospective cohort in the TriNetX federated network, 470 treated vs 470 untreated obese non-diabetic HFpEF patients",
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},
{
"kind": "item",
"title": "Korean adults with depression and unstable incomes have 18% higher mortality",
"excerpt": "Among 735,922 Korean adults diagnosed with depression, those with the most variable annual incomes had 18% higher mortality over a mean 10.3 years than those with the most stable.",
"url": "https://www.coios.me/income-volatility-tracks-18-higher-mortality-in-korean/",
"published_at": "2026-09-26T09:26:58.000Z",
"updated_at": "2026-10-18T12:16:42.000Z",
"domain": "Health today",
"drivers": [
"Mental health"
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"d-mental-health"
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"countries": [
"South Korea"
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"country_codes": [
"kr"
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.3346/jkms.2026.41.e254",
"source": "Journal of Korean Medical Science, 21 September 2026",
"paper_title": "Income Volatility and Risk of All-Cause Mortality and Cause-Specific Hospitalization Among Adults With Depression: A Nationwide Cohort Study",
"authors": "Cho H, Hwang Y, Lee H, Shinn AK, Tsai AC, Hajek A et al.",
"doi": "10.3346/jkms.2026.41.e254",
"type": "Peer-reviewed article",
"design": "National health insurance claims cohort, 735,922 Korean adults newly diagnosed with depression 2008-2012, followed 2013-2023 (7.6m person-years, 90,087 deaths), overlap propensity score weighting",
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},
{
"kind": "item",
"title": "Depression in US asthma patients was linked to 9.9 months shorter survival",
"excerpt": "Among 4,945 US adults with asthma, those with depressive symptoms lived 9.9 months less over 15 years, with income accounting for about a quarter of the difference.",
"url": "https://www.coios.me/depressed-adults-with-asthma-lost-9-9-months-of-survival/",
"published_at": "2026-09-26T09:21:36.000Z",
"updated_at": "2026-10-18T12:16:42.000Z",
"domain": "Health today",
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"d-mental-health"
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"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1155/da/8153352",
"source": "Depression and Anxiety, 19 September 2026",
"paper_title": "The Association Between Depression and Survival in Asthma: The Mediating Role of Income",
"authors": "Wang Z, Teng X",
"doi": "10.1155/da/8153352",
"type": "Peer-reviewed article",
"design": "Cohort analysis of 4,945 adults with asthma, NHANES 2005–2018 linked to National Death Index through 2019, with Cox and restricted mean survival time models",
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},
{
"kind": "item",
"title": "Most people with HIV starting fostemsavir were still taking it a year later",
"excerpt": "A retrospective cohort of 77 adults starting fostemsavir in US clinical practice found most still taking it at 12 months, and most of those already suppressed stayed suppressed.",
"url": "https://www.coios.me/most-us-patients-starting-fostemsavir-remained-on-it-at-12/",
"published_at": "2026-09-26T09:19:52.000Z",
"updated_at": "2026-10-18T12:16:42.000Z",
"domain": "Behavioural science",
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"driver_slugs": [
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"United States"
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"country_codes": [
"us"
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1111/hiv.70303",
"source": "HIV Medicine, 22 September 2026",
"paper_title": "Real-world use and effectiveness of fostemsavir in a US clinical setting: Insights from Trio Health HIV Research Network",
"authors": "Elion R, Henegar C, McEwen I, Frick A, Ramgopal M, Santiago S et al.",
"doi": "10.1111/hiv.70303",
"type": "Peer-reviewed article",
"design": "Retrospective cohort of 77 adults initiating fostemsavir in US clinical practice, July 2020–August 2023, followed 12 months",
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"latency": "",
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},
{
"kind": "item",
"title": "Machine learning model predicted deaths best in diabetes with hypertension",
"excerpt": "Among 2,428 US adults with type 2 diabetes and hypertension in NHANES, a random forest predicted death with an AUC of 0.873, against 0.783 for logistic regression.",
"url": "https://www.coios.me/a-random-forest-beat-logistic-regression-at-predicting/",
"published_at": "2026-09-26T09:19:19.000Z",
"updated_at": "2026-10-18T12:16:42.000Z",
"domain": "Data, models and systems",
"drivers": [
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"countries": [
"United States"
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"us"
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.2196/85557",
"source": "JMIR Medical Informatics, 22 September 2026",
"paper_title": "Development and Validation of a Machine Learning-Based Model for Predicting All-Cause Mortality Risk in Patients With Type 2 Diabetes Mellitus Combined With Hypertension: National Cohort Study",
"authors": "Ding W, Fang L, Fang C",
"doi": "10.2196/85557",
"type": "Peer-reviewed article",
"design": "Prediction model development on NHANES 1999-2018 linked to deaths to 2019; n=2428 adults with type 2 diabetes and hypertension, 719 deaths, median follow-up 6.75 years",
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},
{
"kind": "item",
"title": "Lagos wastewater sequencing found enteric viruses, Vibrio cholerae and resistance genes",
"excerpt": "Sequencing of untreated wastewater from Lagos drainage canals in July and August 2024 detected enteric viruses, Vibrio cholerae and genes conferring resistance to several antibiotic classes.",
"url": "https://www.coios.me/wastewater-sequencing-in-lagos-found-enteric-viruses/",
"published_at": "2026-09-25T13:02:46.000Z",
"updated_at": "2026-10-18T12:16:42.000Z",
"domain": "Behavioural science",
"drivers": [
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"driver_slugs": [
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"countries": [
"Nigeria"
],
"country_codes": [
"ng"
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"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.09.22.26363641",
"source": "medRxiv, 23 September 2026",
"paper_title": "Wastewater metagenomic sequencing enables broad pathogen and resistome monitoring in Lagos, Nigeria",
"authors": "Parker E, Oladipo F, Levy JI, Ope-Ewe OO, Soumare H, Andersen K et al.",
"doi": "10.64898/2026.09.22.26363641",
"type": "Preprint",
"design": "Virus-enriched metagenomic and metatranscriptomic sequencing of untreated wastewater from open drainage canals, Lagos, July–August 2024",
"coverage": "",
"granularity": "",
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},
{
"kind": "item",
"title": "Older breast cancer survivors still score lower on physical function after ten years",
"excerpt": "Among 45,530 Women's Health Initiative participants, women with regional breast cancer scored 6.8 points below matched cancer-free women on physical function at one year and 5.3 points below at ten.",
"url": "https://www.coios.me/older-breast-cancer-survivors-still-carried-a-physical/",
"published_at": "2026-09-25T12:55:59.000Z",
"updated_at": "2026-10-18T12:16:43.000Z",
"domain": "Health today",
"drivers": [
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"d-frailty-multimorbidity",
"d-diet-activity"
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"country_codes": [
"us"
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1093/jnci/djag292",
"source": "JNCI: Journal of the National Cancer Institute, 23 September 2026",
"paper_title": "Lifestyle and chemotherapy shape functional aging trajectories in older breast cancer survivors and matched comparators",
"authors": "Cespedes Feliciano EM, Fuller SE, Nugent JR, Cao A, Anderson GL, Paskett ED et al.",
"doi": "10.1093/jnci/djag292",
"type": "Peer-reviewed article",
"design": "Prospective cohort, Women's Health Initiative, n=45,530 (8,334 survivors), repeated SF-36 over 15 years, with grip strength and walking pace in a subset of 3,015",
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"granularity": "",
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},
{
"kind": "item",
"title": "Later-born Chinese older adults spend more years happy, with widening education gaps",
"excerpt": "Analysis of the Chinese Longitudinal Healthy Longevity Survey from 2002 to 2018 found that each later-born cohort of older adults spent a higher proportion of its remaining life happy.",
"url": "https://www.coios.me/later-chinese-cohorts-spend-more-years-happy-with-gaps/",
"published_at": "2026-09-25T12:50:03.000Z",
"updated_at": "2026-10-18T12:16:43.000Z",
"domain": "Data, models and systems",
"drivers": [
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"China"
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"country_codes": [
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1186/s41118-026-00298-z",
"source": "Genus, 24 September 2026",
"paper_title": "Are older adults in China living longer happy years? A cohort-based multistate analysis, 2002–2018",
"authors": "Wan Y, Bousmah MaQ, Nepomuceno MR",
"doi": "10.1186/s41118-026-00298-z",
"type": "Peer-reviewed article",
"design": "Cohort-based multistate life table analysis of the Chinese Longitudinal Healthy Longevity Survey, paired birth cohorts 10 years apart, 2002–2018",
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},
{
"kind": "item",
"title": "Abdominal obesity and high blood sugar rose in Korean screening from 2014 to 2023",
"excerpt": "Aggregated national health screening statistics for the Republic of Korea show abdominal obesity rising from 21.0% to 25.5% between 2014 and 2023, with hyperglycaemia and hypertension also higher.",
"url": "https://www.coios.me/abdominal-obesity-and-high-blood-sugar-rose-in-korean/",
"published_at": "2026-09-25T12:48:25.000Z",
"updated_at": "2026-10-18T12:16:43.000Z",
"domain": "Health today",
"drivers": [
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"d-obesity-diabetes"
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"countries": [
"South Korea"
],
"country_codes": [
"kr"
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.24171/j.phrp.2026.0195",
"source": "Osong Public Health and Research Perspectives, 23 September 2026",
"paper_title": "Age- and sex-specific patterns in the prevalence of metabolic syndrome components in the Republic of Korea, 2014-2023: a repeated cross-sectional study of national health screening statistics",
"authors": "Jang YM, Son WH",
"doi": "10.24171/j.phrp.2026.0195",
"type": "Peer-reviewed article",
"design": "Repeated cross-sectional analysis of aggregated national health screening statistics, Republic of Korea, 2014-2023",
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},
{
"kind": "item",
"title": "Isolation's link with death was weaker in UK Biobank adults using mixed transport",
"excerpt": "Social isolation carried a hazard ratio of 1.34 for all-cause death in 490,114 UK Biobank adults, and the link was weaker in those using a car alongside other transport.",
"url": "https://www.coios.me/socially-isolated-uk-biobank-participants-had-34-higher-all/",
"published_at": "2026-09-25T12:45:21.000Z",
"updated_at": "2026-10-18T12:16:43.000Z",
"domain": "Behavioural science",
"drivers": [
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"driver_slugs": [
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"countries": [
"United Kingdom"
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"country_codes": [
"gb"
],
"source_type": "preprint",
"verdict": "confirms",
"source_url": "https://doi.org/10.64898/2026.09.21.26363514",
"source": "medRxiv, 23 September 2026",
"paper_title": "Social Isolation and All-Cause and Cause-Specific Mortality in the UK Biobank: The Modifying Role of Non-Commute Transportation Mode",
"authors": "Hum ED, Lapointe Y, Baumgartner J, Manaugh K, Mamiya H",
"doi": "10.64898/2026.09.21.26363514",
"type": "Preprint",
"design": "Prospective cohort, UK Biobank, 490,114 adults aged 40-69, 2006-2022, Cox models with interaction terms",
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"latency": "",
"access": "",
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},
{
"kind": "item",
"title": "Parathyroid cancer in Korea rose fivefold, and benign parathyroid disease faster still",
"excerpt": "In Korean national insurance data from 2005 to 2020, incident parathyroid cancer rose 5.0-fold and benign primary hyperparathyroidism 7.7-fold, with ten-year all-cause mortality raised in both against matched controls.",
"url": "https://www.coios.me/parathyroid-carcinoma-rose-fivefold-in-korea-with-double/",
"published_at": "2026-09-25T12:45:11.000Z",
"updated_at": "2026-10-18T12:16:43.000Z",
"domain": "Health today",
"drivers": [
"Cancer"
],
"driver_slugs": [
"d-cancer"
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"countries": [
"South Korea"
],
"country_codes": [
"kr"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1530/erc-26-0259",
"source": "Endocrine-Related Cancer, 23 September 2026",
"paper_title": "Parathyroid Carcinoma and Primary Hyperparathyroidism: Trends and Outcomes",
"authors": "Baek S, Yu MH, Kim DW, Kim CG, Shin NY, Kim M et al.",
"doi": "10.1530/erc-26-0259",
"type": "Peer-reviewed article",
"design": "National health insurance cohort, Korea 2005-2020: 296 parathyroid carcinoma, 6,837 benign primary hyperparathyroidism, 71,330 matched controls",
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},
{
"kind": "item",
"title": "Two in five memory-clinic patients with subjective complaints were amyloid-positive",
"excerpt": "In 194 consecutive memory-clinic patients, amyloid PET positivity rose from 40.9% in those with subjective complaints to 91.7% in those with early Alzheimer's disease, with MRI adding nothing.",
"url": "https://www.coios.me/two-in-five-memory-clinic-patients-with-only-subjective/",
"published_at": "2026-09-25T12:40:58.000Z",
"updated_at": "2026-10-18T12:16:43.000Z",
"domain": "Health today",
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"Dementia"
],
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"d-dementia"
],
"countries": [
"Japan"
],
"country_codes": [
"jp"
],
"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1177/13872877261490596",
"source": "Journal of Alzheimer’s Disease, 23 September 2026",
"paper_title": "Clinic-based real-world analysis of amyloid PET positivity and MRI markers across subjective cognitive decline, mild cognitive impairment, and early Alzheimer's disease",
"authors": "Arai H, Aiba S, Yamamoto H, Akiba Y, Takayama J, Arai R",
"doi": "10.1177/13872877261490596",
"type": "Peer-reviewed article",
"design": "Retrospective consecutive memory-clinic cohort, 194 patients undergoing 18F-florbetapir amyloid PET, MRI/VSRAD in 153",
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},
{
"kind": "item",
"title": "Side-branch lesions had less restenosis with drug-coated balloons than with stents",
"excerpt": "In 161 patients with isolated side-branch coronary lesions, binary restenosis at one year was 7.4% after a drug-coated balloon strategy against 21.3% after stenting, with treatment chosen by the operator.",
"url": "https://www.coios.me/drug-coated-balloons-showed-less-restenosis-than-stents-in/",
"published_at": "2026-09-25T12:25:16.000Z",
"updated_at": "2026-10-18T12:16:44.000Z",
"domain": "Health today",
"drivers": [
"Heart and stroke"
],
"driver_slugs": [
"d-cardiovascular"
],
"countries": [],
"country_codes": [],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1002/ccd.70919",
"source": "Catheterization and Cardiovascular Interventions, 23 September 2026",
"paper_title": "Drug-Coated Balloon Versus Stenting for Medina 0.0.1 Coronary Bifurcation Lesions: One-Year Clinical and Angiographic Outcomes of a Leave-Nothing-Behind Strategy",
"authors": "Gad AA, Hal MMAK, Mokarrab ME, Attia MA, Abouelmagd K, Ahmed WO",
"doi": "10.1002/ccd.70919",
"type": "Peer-reviewed article",
"design": "Prospective observational cohort, 161 patients with Medina 0.0.1 bifurcation lesions, 1-year angiographic and clinical follow-up",
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},
{
"kind": "item",
"title": "Diets of Swiss childhood cancer survivors were unrelated to cardiovascular risk",
"excerpt": "Among 802 Swiss adults treated for cancer before the age of 21, five dietary patterns were identified, none of which was associated with cardiovascular disease or its risk factors.",
"url": "https://www.coios.me/swiss-childhood-cancer-survivors-diets-tracked-social/",
"published_at": "2026-09-25T12:25:12.000Z",
"updated_at": "2026-10-18T12:16:44.000Z",
"domain": "Behavioural science",
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"Diet, exercise and sleep",
"Cancer",
"Obesity, diabetes and GLP-1"
],
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"d-diet-activity",
"d-cancer",
"d-obesity-diabetes"
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"countries": [
"Switzerland"
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"ch"
],
"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.09.22.26363621",
"source": "medRxiv, 23 September 2026",
"paper_title": "Dietary Patterns and Cardiovascular Risk in Adult Survivors of Childhood Cancer: Findings From the SCCSS-Nutrition Study",
"authors": "Li R, Revuelta Iniesta R, Barker AR, Chatelan A, Leuenberger L, Shoman Y et al.",
"doi": "10.64898/2026.09.22.26363621",
"type": "Preprint",
"design": "Cross-sectional food frequency questionnaire study, 802 Swiss adult childhood cancer survivors diagnosed 1976-2005, surveyed from 2017",
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},
{
"kind": "item",
"title": "Kidney cancer mortality fell in Medicaid expansion states, but not for Black patients",
"excerpt": "Among 284,967 US adults aged 40 to 64 with renal cell carcinoma, overall mortality was 7.5% lower in Medicaid expansion states, with no change in five-year survival for Black patients.",
"url": "https://www.coios.me/medicaid-expansion-tracked-lower-mortality-after-kidney/",
"published_at": "2026-09-24T08:52:23.000Z",
"updated_at": "2026-10-18T12:16:44.000Z",
"domain": "Health today",
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"Cancer",
"Health systems and access"
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"d-cancer",
"d-health-systems"
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"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1016/j.jss.2026.08.036",
"source": "Journal of Surgical Research, 22 September 2026",
"paper_title": "Medicaid Expansion and Overall Mortality Among Individuals With Renal Cell Carcinoma",
"authors": "Akinyemi O, Oyebanji O, Fasokun M, Mba-Madubuike I, Singleton D, Hughes K et al.",
"doi": "10.1016/j.jss.2026.08.036",
"type": "Peer-reviewed article",
"design": "Retrospective difference-in-differences cohort, National Cancer Database, 284,967 adults aged 40-64 with renal cell carcinoma, 2006-2021",
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"granularity": "",
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},
{
"kind": "item",
"title": "Liraglutide's benefit in US veterans may be larger than the LEADER trial found",
"excerpt": "Reweighting the LEADER trial onto US veterans with diabetes gave a three-year reduction in major cardiovascular events of 4.6% against 1.6%, a difference within statistical uncertainty.",
"url": "https://www.coios.me/carried-to-us-veterans-liraglutide-s-three-year-benefit/",
"published_at": "2026-09-24T08:48:40.000Z",
"updated_at": "2026-10-18T12:16:44.000Z",
"domain": "Health today",
"drivers": [
"Obesity, diabetes and GLP-1"
],
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"d-obesity-diabetes"
],
"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1093/aje/kwag236",
"source": "American Journal of Epidemiology, 22 September 2026",
"paper_title": "Real-world cardiovascular effects of liraglutide: transportability analysis of the LEADER trial",
"authors": "Josey K, Liu W, Warsavage T, Medici M, Kvist K, Derington CG et al.",
"doi": "10.1093/aje/kwag236",
"type": "Peer-reviewed article",
"design": "Transportability analysis reweighting the LEADER randomised trial onto US Veterans Affairs cohorts with type 2 diabetes, using augmented inverse probability weighting and approximate balancing weights",
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},
{
"kind": "item",
"title": "COVID-19 antibody levels overstate protection in people on immunosuppressive therapy",
"excerpt": "Binding antibody levels after mRNA vaccination were 54.5 times lower in people on B-cell depleting drugs than in healthy controls, and protection was lower at any given antibody level.",
"url": "https://www.coios.me/immunosuppressed-people-are-less-protected-than-their/",
"published_at": "2026-09-24T08:45:13.000Z",
"updated_at": "2026-10-18T12:16:44.000Z",
"domain": "Behavioural science",
"drivers": [
"Infection and pandemics"
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"d-infectious-disease"
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"countries": [
"World"
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"country_codes": [
"world"
],
"source_type": "preprint",
"verdict": "refines",
"source_url": "https://doi.org/10.64898/2026.09.16.26363194",
"source": "medRxiv, 22 September 2026",
"paper_title": "Immunogenicity and vaccine effectiveness of COVID-19 vaccines in people on immunosuppressive therapies",
"authors": "Stadler E, Khan SR, Elias KM, Egilmezer E, Phetsouphanh C, Hastak P et al.",
"doi": "10.64898/2026.09.16.26363194",
"type": "Preprint",
"design": "Systematic review and meta-analysis of post-mRNA-vaccination binding antibody levels across immunosuppressive therapy cohorts and healthy controls, linked to existing vaccine effectiveness estimates",
"coverage": "",
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},
{
"kind": "item",
"title": "Combined conditions add mortality beyond their separate effects after emergency surgery",
"excerpt": "Among 61,400 Danish adults having major emergency abdominal surgery, 31% died within a year, and several combinations of chronic conditions were associated with mortality beyond their effects in isolation.",
"url": "https://www.coios.me/pairs-of-conditions-carry-mortality-beyond-the-sum-of-their/",
"published_at": "2026-09-24T08:43:02.000Z",
"updated_at": "2026-10-18T12:16:45.000Z",
"domain": "Health today",
"drivers": [
"Frailty and multimorbidity"
],
"driver_slugs": [
"d-frailty-multimorbidity"
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"countries": [
"Denmark"
],
"country_codes": [
"dk"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1097/ta.0000000000005168",
"source": "Journal of Trauma and Acute Care Surgery, 22 September 2026",
"paper_title": "Impact of systemic comorbidities and interaction patterns on mortality following major emergency abdominal surgery: A nationwide register-based cohort study",
"authors": "Gormsen J, Kokotovic D, Burcharth J, Jensen TK",
"doi": "10.1097/ta.0000000000005168",
"type": "Peer-reviewed article",
"design": "Nationwide register-based cohort, all adults undergoing major emergency abdominal surgery in Denmark 2002-2022, n=61,400, with LASSO regression for comorbidity interactions",
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},
{
"kind": "item",
"title": "Smokers and e-cigarette users with a smoking history report more long-standing illness",
"excerpt": "In the 2022 Health Survey for England, those who both smoked and vaped had 2.35 times the adjusted odds of a long-standing condition as never users, and smokers 1.87 times.",
"url": "https://www.coios.me/vapers-who-never-smoked-show-no-clear-excess-illness-in-an/",
"published_at": "2026-09-24T08:38:35.000Z",
"updated_at": "2026-10-18T12:16:45.000Z",
"domain": "Behavioural science",
"drivers": [
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],
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"d-smoking-vaping"
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"countries": [
"United Kingdom"
],
"country_codes": [
"gb"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1016/j.jeph.2026.203800",
"source": "Journal of Epidemiology and Population Health, 22 September 2026",
"paper_title": "Heterogeneous associations between cigarette and e-cigarette use patterns and chronic disease burden: A population-based study",
"authors": "Adebisi YA, Cantone G, Bafail DA, Ogunkola IO, Tomaselli V, Shukri AK et al.",
"doi": "10.1016/j.jeph.2026.203800",
"type": "Peer-reviewed article",
"design": "Cross-sectional analysis of the 2022 Health Survey for England, 7,625 adults aged 16+, survey-weighted ordered logistic regression",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
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},
{
"kind": "item",
"title": "Genomic testing reached 38% of Ohio Medicaid women with ER-positive early breast cancer",
"excerpt": "Among 1,988 Ohio Medicaid patients with early ER-positive breast cancer, 37.8% received Oncotype DX or MammaPrint within six months, with receipt lower for regional than localised disease (aOR 0.35).",
"url": "https://www.coios.me/only-38-of-ohio-medicaid-women-with-early-breast-cancer-had/",
"published_at": "2026-09-24T08:38:23.000Z",
"updated_at": "2026-10-18T12:16:45.000Z",
"domain": "Health today",
"drivers": [
"Cancer",
"Health systems and access"
],
"driver_slugs": [
"d-cancer",
"d-health-systems"
],
"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1200/op-26-00255",
"source": "JCO Oncology Practice, 22 September 2026",
"paper_title": "Missed Precision: Gaps in Molecular Profiling Among Medicaid Patients With Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer",
"authors": "Lal T, Vu L, Abou Zeidane R, Pisano C, Shoag J, Hoehn RS et al.",
"doi": "10.1200/op-26-00255",
"type": "Peer-reviewed article",
"design": "Retrospective cohort, Ohio cancer registry linked to Medicaid claims, n=1,988 diagnosed 2016-2020",
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"granularity": "",
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},
{
"kind": "item",
"title": "CT surveillance after lung cancer surgery did not change patients' quality of life",
"excerpt": "In the IFCT-0302 trial, 1,775 patients resected for non-small cell lung cancer were randomised to CT or minimal follow-up, with no difference in time to deterioration in quality of life.",
"url": "https://www.coios.me/ct-surveillance-after-lung-cancer-surgery-left-quality-of/",
"published_at": "2026-09-24T08:34:32.000Z",
"updated_at": "2026-10-18T12:16:45.000Z",
"domain": "Health today",
"drivers": [
"Cancer"
],
"driver_slugs": [
"d-cancer"
],
"countries": [
"France"
],
"country_codes": [
"fr"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1016/j.jtcvs.2026.08.031",
"source": "The Journal of Thoracic and Cardiovascular Surgery, 22 September 2026",
"paper_title": "Impact of CT scan-based vs. minimal follow-up on patient-reported outcomes after surgery for non-small cell lung cancer in IFCT-0302 phase III trial",
"authors": "Eberst G, Henriques J, Thomas PA, Giroux-Leprieur E, Mercier O, Pagès PB et al.",
"doi": "10.1016/j.jtcvs.2026.08.031",
"type": "Peer-reviewed article",
"design": "Prespecified secondary patient-reported outcome analysis of the IFCT-0302 randomised phase III trial, n=1775, SF-12 to 5 years",
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},
{
"kind": "item",
"title": "Fentanyl was present in three quarters of cocaine overdose deaths in Cuyahoga County",
"excerpt": "Of 1,150 unintentional cocaine-related overdose deaths in Cuyahoga County, Ohio, from 2014 to 2024, fentanyl was also present in 74.6%, with the two groups differing by age and race.",
"url": "https://www.coios.me/fentanyl-was-present-in-three-quarters-of-cocaine-overdose/",
"published_at": "2026-09-24T08:34:10.000Z",
"updated_at": "2026-10-18T12:16:45.000Z",
"domain": "Behavioural science",
"drivers": [
"Alcohol and drug use"
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"driver_slugs": [
"d-alcohol-drugs"
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"countries": [
"United States"
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"country_codes": [
"us"
],
"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1097/paf.0000000000001172",
"source": "American Journal of Forensic Medicine & Pathology, 22 September 2026",
"paper_title": "Cocaine-Related Overdose Deaths in Cuyahoga County, Ohio, 2014 to 2024: The Impact of Fentanyl on Cocaine Related Overdose Deaths",
"authors": "Becker C, Bhullar MK, Franks S, Gilson T, Wing JJ",
"doi": "10.1097/paf.0000000000001172",
"type": "Peer-reviewed article",
"design": "Retrospective medical examiner case series, all 1,150 unintentional cocaine-related overdose deaths, Cuyahoga County, Ohio, 2014-2024",
"coverage": "",
"granularity": "",
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},
{
"kind": "item",
"title": "Inherited small vessel disease carriers had higher odds of a worse dementia rating",
"excerpt": "Carriers of a NOTCH3 variant causing CADASIL, an inherited small vessel brain disease, had 2.55 to 5.08 times the odds of a more impaired dementia rating than non-carrier relatives.",
"url": "https://www.coios.me/a-us-cadasil-cohort-finds-raised-cognitive-impairment/",
"published_at": "2026-09-24T08:27:45.000Z",
"updated_at": "2026-10-18T12:16:45.000Z",
"domain": "Health today",
"drivers": [
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"United States"
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"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.09.20.26363512",
"source": "medRxiv, 22 September 2026",
"paper_title": "The United States CADASIL Consortium: Baseline Findings from a Natural History Study",
"authors": "Paulsen JS, Bockholt HJ, Adams WH, Burks DK, Majersik JJ, Salloway SP et al.",
"doi": "10.64898/2026.09.20.26363512",
"type": "Preprint",
"design": "Cross-sectional baseline analysis of a 12-site US longitudinal cohort, 459 analysed (343 NOTCH3 carriers, 116 non-carrier family controls), enrolled October 2022 to January 2025",
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"attention": "1 citation (Crossref) · as of 2026-10-06",
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},
{
"kind": "item",
"title": "Carbapenem resistance was associated with death in ICU-acquired bloodstream infections",
"excerpt": "Among 352 adults at one centre who developed gram-negative bloodstream infection at least 48 hours after ICU admission, half the isolates were carbapenem-resistant and 30-day mortality was 57.9%.",
"url": "https://www.coios.me/carbapenem-resistance-tracked-death-in-icu-acquired/",
"published_at": "2026-09-24T08:25:17.000Z",
"updated_at": "2026-10-18T12:16:46.000Z",
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"countries": [],
"country_codes": [],
"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1007/s11845-026-04643-1",
"source": "Irish Journal of Medical Science (1971 -), 22 September 2026",
"paper_title": "Resistance phenotype, infection source, and empirical therapy in ICU-onset gram-negative bloodstream infections: Associations with 30-day mortality",
"authors": "Kizilcay B, Ozdemir YE",
"doi": "10.1007/s11845-026-04643-1",
"type": "Peer-reviewed article",
"design": "Single-centre retrospective cohort, 352 adults with ICU-onset gram-negative bloodstream infection, 2021-2025",
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},
{
"kind": "item",
"title": "Childhood obesity fell four percentage points after school programmes in Spain",
"excerpt": "A meta-analysis of seven school programmes in 6,716 Spanish schoolchildren found obesity prevalence 4.00 percentage points lower after them, from a baseline of 10.3%.",
"url": "https://www.coios.me/school-programmes-in-spain-cut-childhood-obesity-by-four/",
"published_at": "2026-09-24T08:12:34.000Z",
"updated_at": "2026-10-18T12:16:46.000Z",
"domain": "Health today",
"drivers": [
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"Diet, exercise and sleep"
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"driver_slugs": [
"d-obesity-diabetes",
"d-diet-activity"
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"countries": [
"Spain"
],
"country_codes": [
"es"
],
"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1016/j.aprim.2026.103609",
"source": "Atención Primaria, 22 September 2026",
"paper_title": "[Effectiveness of interventions in schools for the prevention and reduction of childhood obesity and overweight: A systematic review and meta-analysis]",
"authors": "Méndez-López F, Aguilar-Latorre A, Vicente-García C, Gastón-Faci A, Magallón-Botaya R",
"doi": "10.1016/j.aprim.2026.103609",
"type": "Peer-reviewed article",
"design": "Systematic review and meta-analysis of seven Spanish school-based intervention studies, 6,716 schoolchildren, 2010-2025",
"coverage": "",
"granularity": "",
"latency": "",
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},
{
"kind": "item",
"title": "Galleri blood test found 26.7% to 37.2% of cancers per screening round",
"excerpt": "In the NHS-Galleri trial of 142,250 adults aged 50 to 77, the multi-cancer blood test detected between 26.7% and 37.2% of cancers in each of three annual screening rounds.",
"url": "https://www.coios.me/a-blood-test-found-between-a-quarter-and-a-third-of-cancers/",
"published_at": "2026-09-23T13:27:00.000Z",
"updated_at": "2026-10-18T12:16:46.000Z",
"domain": "Health today",
"drivers": [
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],
"driver_slugs": [
"d-cancer"
],
"countries": [
"United Kingdom"
],
"country_codes": [
"gb"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1038/s41591-026-04652-8",
"source": "Nature Medicine, 22 September 2026",
"paper_title": "Performance of a multi-cancer early detection test in the randomized controlled NHS-Galleri trial",
"authors": "Neal RD, Dolly S, Johnson P, Jones H, Kumar SH, Lee LYW et al.",
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{
"kind": "item",
"title": "GLP-1 prescribing without an approved indication rose fifteenfold in US adults",
"excerpt": "Among 92.4 million US adults with no recorded type 2 diabetes or qualifying obesity, GLP-1 prescribing rose from 0.1% in 2021 to 1.5% in 2025.",
"url": "https://www.coios.me/off-label-glp-1-prescribing-in-us-adults-rose-15-fold-a/",
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"source_url": "https://doi.org/10.1002/oby.70301",
"source": "Obesity, 22 September 2026",
"paper_title": "Trends in GLP-1 Receptor Agonist Prescribing Without an Apparent FDA-Approved Indication",
"authors": "Orandi BJ, Yan L, Levan ML, Lofton HF, Chhabra KR, Ren-Fielding CJ et al.",
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"kind": "item",
"title": "GLP-1 drugs lower stroke risk by 17%, little of it explained by blood pressure",
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"source_url": "https://doi.org/10.64898/2026.09.18.26363449",
"source": "medRxiv, 21 September 2026",
"paper_title": "GLP-1 Receptor Agonists, Stroke, and Cognitive Outcomes: Systematic Review and Meta-Regression",
"authors": "Danielli M, Sibal R, Collett G, Awan H, Sharma C, Steckelmacher J et al.",
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"source_url": "https://doi.org/10.1136/fmch-2026-003925",
"source": "Family medicine and community health, 22 September 2026",
"paper_title": "Ultra-processed food consumption and risk of multiple chronic diseases among 8,819,894 adults from 51 prospective cohorts: a dose-response meta-analysis",
"authors": "Liu X, Luo S, Zeng Y, Peng N, Chen X, Tian J et al.",
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"attention": "1 citation (Crossref) · as of 2026-10-20",
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{
"kind": "item",
"title": "Despair did not explain rising midlife mortality among white US adults",
"excerpt": "Among US adults aged 45-54 between 1999 and 2015, death rates rose for white adults, but the 0.13% rise in reported despair did not track that increase.",
"url": "https://www.coios.me/rising-despair-did-not-track-the-midlife-white-us-mortality/",
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"source_url": "https://doi.org/10.1093/aje/kwag235",
"source": "American Journal of Epidemiology, 21 September 2026",
"paper_title": "Does despair drive increases in white mortality, or did the narrative get ahead of the data?",
"authors": "Segura LE, Zepeda-Tello R, Prins SJ, Martins SS",
"doi": "10.1093/aje/kwag235",
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{
"kind": "item",
"title": "Not-for-profit Australian care homes had lower mortality in inner regional areas",
"excerpt": "Among 205,079 Australians entering long-term care, deaths in the first year were higher in for-profit (HR 1.17) and government (HR 1.20) homes than not-for-profit homes in inner regional areas.",
"url": "https://www.coios.me/australian-care-home-mortality-differed-by-ownership-mainly/",
"published_at": "2026-09-23T13:08:00.000Z",
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1136/bmjopen-2026-117917",
"source": "BMJ Open, 20 September 2026",
"paper_title": "Association of long-term care facility ownership and location on residents' mortality and hospitalisations: A population-based retrospective cohort study in Australia",
"authors": "Rahja M, Davies LW, Jorissen RN, Crotty M, Whitehead C, Evans K et al.",
"doi": "10.1136/bmjopen-2026-117917",
"type": "Peer-reviewed article",
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{
"kind": "item",
"title": "AI reading breast pathology slides identified which patients gained from chemotherapy",
"excerpt": "Applied to 6,735 TAILORx trial patients without retraining, an AI model reading pathology slides identified intermediate-risk patients who gained 5 percentage points in five-year disease-free interval from chemotherapy.",
"url": "https://www.coios.me/ai-on-breast-biopsy-slides-flagged-intermediate-risk/",
"published_at": "2026-09-23T13:06:00.000Z",
"updated_at": "2026-10-18T12:16:47.000Z",
"domain": "Data, models and systems",
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"source_type": "preprint",
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"source_url": "https://doi.org/10.64898/2026.09.12.26362500",
"source": "medRxiv, 20 September 2026",
"paper_title": "An AI Model Identifies Chemotherapy Benefit in Node-Negative HR+/HER2-Breast Cancer Patients from TAILORx, a Phase 3 Randomized Clinical Trial",
"authors": "Chan N, Tang C, Biswas D, Park J, Zeng KG, Cappadona J et al.",
"doi": "10.64898/2026.09.12.26362500",
"type": "Preprint",
"design": "Prespecified secondary analysis of the TAILORx phase 3 randomised trial, 6,735 patients with H&E slides and 21-gene Recurrence Score, using an AI model not trained on trial data",
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{
"kind": "item",
"title": "Stroke prevention texts raised cardiovascular check-ups, an online course did not",
"excerpt": "In an Australian trial of 941 adults aged 45 and over, self-reported visits for cardiovascular risk assessment were 41.3% in the text message arm as compared to 29.0% in control.",
"url": "https://www.coios.me/text-messages-raised-cardiovascular-check-up-visits-where/",
"published_at": "2026-09-23T13:02:07.000Z",
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"domain": "Tomorrow's world",
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"source_type": "peer-reviewed",
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"source_url": "https://doi.org/10.1177/17474930261494297",
"source": "International Journal of Stroke, 22 September 2026",
"paper_title": "Cardiovascular risk management through a community-based digital health stroke education platform (Love Your Brain): a multi-arm randomized controlled trial",
"authors": "Kilkenny MF, Burns C, Freak-Poli R, Purvis T, Olaiya MT, Dalli LL et al.",
"doi": "10.1177/17474930261494297",
"type": "Peer-reviewed article",
"design": "Single-blinded three-arm randomised controlled trial, n=941 Australians aged 45+ without prior cardiovascular events, Feb-Sep 2025, 12-week follow-up",
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{
"kind": "item",
"title": "Scottish children in care had higher rates of mental health hospitalisation",
"excerpt": "In linked Scottish health and social care records, care-experienced girls had 3.22 times the risk of a first mental health admission, and boys 2.64 times, compared with the general population.",
"url": "https://www.coios.me/care-experienced-scottish-children-had-roughly-triple-the/",
"published_at": "2026-09-23T13:02:06.000Z",
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"domain": "Data, models and systems",
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"source_type": "peer-reviewed",
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"source_url": "https://doi.org/10.1111/camh.70132",
"source": "Child and Adolescent Mental Health, 22 September 2026",
"paper_title": "Mental health hospitalisations of care-experienced and general-population children with chronic conditions: evidence from the Children's Health in Care in Scotland (CHiCS) study, a population-wide longitudinal study using administrative data",
"authors": "Gedeon E, Leyland AH, Henderson M, Allik M",
"doi": "10.1111/camh.70132",
"type": "Peer-reviewed article",
"design": "Population-wide administrative data linkage cohort, 13,830 care-experienced and 649,771 general-population children in Scotland, births 1990-2004 followed to 2016; Cox and negative binomial models",
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{
"kind": "item",
"title": "Slow walking and a low cognitive score at 66 predict dementia in Korea",
"excerpt": "Among 741,655 Korean adults screened at age 66, those with both a low cognitive test score and slow walking had 1.74 times the dementia risk over a mean 10.9 years.",
"url": "https://www.coios.me/slow-gait-and-a-low-cognitive-score-at-66-together-predict/",
"published_at": "2026-09-23T13:02:05.000Z",
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.12701/jyms.2026.43.67",
"source": "Journal of Yeungnam Medical Science, 21 September 2026",
"paper_title": "Association of combined mobility and cognitive impairments with adverse health outcomes in adults aged 66 years: a nationwide cohort study",
"authors": "Ryu SY, Park S, Yun J",
"doi": "10.12701/jyms.2026.43.67",
"type": "Peer-reviewed article",
"design": "National health-insurance cohort, 741,655 Korean adults aged 66 screened 2009-2012, mean 10.9 years follow-up",
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"kind": "item",
"title": "Carbapenemase-producing Enterobacterales doubled every 2.4 years in French hospitals",
"excerpt": "In French hospitals between 2019 and 2024, carbapenemase-producing Enterobacterales rose 32.8% a year and doubled every 2.4 years, while the far commoner extended-spectrum beta-lactamase producers remained stable.",
"url": "https://www.coios.me/carbapenemase-producing-enterobacterales-doubled-every-2-4/",
"published_at": "2026-09-23T13:02:04.000Z",
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"source_url": "https://doi.org/10.1016/j.jhin.2026.09.022",
"source": "Journal of Hospital Infection, 22 September 2026",
"paper_title": "Divergent epidemic trajectories of ESBL-producing and carbapenemase-producing Enterobacterales in French hospitals: a nationwide modelling study",
"authors": "Davido B, Rouillard L, Leroux P, Durand M, Saleh-Mghir A",
"doi": "10.1016/j.jhin.2026.09.022",
"type": "Peer-reviewed article",
"design": "Retrospective log-linear modelling of national hospital surveillance (SPARES), France, 2019-2024",
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{
"kind": "item",
"title": "Former US service members die more often of alcohol, drugs or suicide than civilians",
"excerpt": "Among 176,719 deaths at ages 18-64 in Massachusetts and Minnesota, alcohol, drug and suicide causes accounted for 12% and 7% more of former service members' deaths than of non-military deaths.",
"url": "https://www.coios.me/former-us-service-members-died-of-despair-causes-more-often/",
"published_at": "2026-09-23T13:02:03.000Z",
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"source_url": "https://doi.org/10.1093/aje/kwag233",
"source": "American Journal of Epidemiology, 21 September 2026",
"paper_title": "Deaths of Despair among Former Military Service Members, Massachusetts (2014-2021) and Minnesota (2014-2022)",
"authors": "Holliday KM, Hill ED, Batchelder HR, Price AE, Johnson CY, Viera AJ et al.",
"doi": "10.1093/aje/kwag233",
"type": "Peer-reviewed article",
"design": "Linkage of state death certificates to military personnel files, 176,719 decedents aged 18-64 (Massachusetts 2014-2021, Minnesota 2014-2022)",
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"kind": "item",
"title": "Social media alerts driven by wastewater data did not raise seasonal vaccination",
"excerpt": "A county-randomised trial across 40 New York State counties found that an 11-week campaign of wastewater-triggered social media alerts made no difference to COVID-19 or influenza vaccination over the season.",
"url": "https://www.coios.me/wastewater-triggered-social-media-ads-did-not-raise-season/",
"published_at": "2026-09-23T13:02:02.000Z",
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"source_url": "https://doi.org/10.64898/2026.09.14.26362268",
"source": "medRxiv, 21 September 2026",
"paper_title": "Boosting vaccination uptake using wastewater surveillance: a county-randomized controlled trial",
"authors": "Blatz MN, Neigel D, Larsen DA, Kmush BL",
"doi": "10.64898/2026.09.14.26362268",
"type": "Preprint",
"design": "County-randomised controlled trial, 40 New York State counties (20 intervention, 20 control), 11-week campaign, autumn 2024",
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{
"kind": "item",
"title": "Air pollution before surgery was associated with higher mortality in gastric cancer",
"excerpt": "In 4,441 patients operated on for stage I-III gastric cancer in China, each standard-deviation rise in PM2.5 before surgery carried 15% higher all-cause mortality and 31% higher gastric cancer mortality.",
"url": "https://www.coios.me/higher-particulate-exposure-before-surgery-tracked-worse/",
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"source_url": "https://doi.org/10.1016/j.envres.2026.125689",
"source": "Environmental Research, 20 September 2026",
"paper_title": "Long-term exposure to particulate matter and survival among patients with gastric cancer: A hospital-based cohort study",
"authors": "Zhu J, Kang N, Wang J, Song L, Li X, Tao H et al.",
"doi": "10.1016/j.envres.2026.125689",
"type": "Peer-reviewed article",
"design": "Hospital-based cohort, 4,441 stage I-III gastric cancer patients after radical surgery, Zhejiang, China, 2012-2022, median follow-up 3.83 years",
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{
"kind": "item",
"title": "Empagliflozin's lower cardiovascular risk is similar across social groups in Medicare",
"excerpt": "In US Medicare claims, empagliflozin initiators aged 65 and over had a hazard ratio of 0.77 for major cardiovascular events against DPP-4 inhibitors, with no variation by social group.",
"url": "https://www.coios.me/empagliflozin-s-cardiovascular-benefit-in-medicare-data/",
"published_at": "2026-09-23T13:02:00.000Z",
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"source_url": "https://doi.org/10.2337/dca26-0039",
"source": "Diabetes Care, 21 September 2026",
"paper_title": "Effects of Empagliflozin on Cardiovascular Outcomes Are Consistent Across Sociodemographic Subgroups: A Real-World Analysis From the EMPRISE Study",
"authors": "Cromer SJ, Tesfaye H, Cho H, Wexler DJ, Ortega-Montiel J, Schmedt N et al.",
"doi": "10.2337/dca26-0039",
"type": "Peer-reviewed article",
"design": "Propensity score-matched new-user cohort in US Medicare claims, 2014-2020, adults aged 65 and over with type 2 diabetes",
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"kind": "item",
"title": "Austrian mortality in 2024 was at or below 2019 at every age over 60",
"excerpt": "Austrian all-cause mortality in 2024 was equal to or lower than in 2019 at every age over 60, despite 1,212 COVID-19 deaths recorded in the year.",
"url": "https://www.coios.me/austrian-all-cause-mortality-in-2024-sat-at-or-below-2019/",
"published_at": "2026-09-23T13:00:03.000Z",
"updated_at": "2026-10-18T12:16:49.000Z",
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"Austria"
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"at"
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://link.springer.com/article/10.1007/s10654-026-01462-7",
"source": "European Journal of Epidemiology, 23 September 2026",
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"authors": "",
"doi": "",
"type": "Peer-reviewed article",
"design": "National retrospective analysis of Austrian death certificates, all-cause and multiple-cause mortality rate ratios, 2024 versus 2017–2019, sex-stratified 10-year age groups",
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{
"kind": "item",
"title": "Current smokers had twice the odds of missing lung screening follow-up",
"excerpt": "In a Japanese community programme, 19.3% of abnormal low-dose CT screens had no documented follow-up within a year, with current smokers at twice the odds of former smokers.",
"url": "https://www.coios.me/current-smokers-were-twice-as-likely-to-skip-follow-up/",
"published_at": "2026-09-23T13:00:02.000Z",
"updated_at": "2026-10-18T12:16:49.000Z",
"domain": "Behavioural science",
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"Smoking and vaping",
"Cancer"
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"d-smoking-vaping",
"d-cancer"
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"Japan"
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"jp"
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1016/j.resinv.2026.101518",
"source": "Respiratory Investigation, 21 September 2026",
"paper_title": "Smoking status and adherence to diagnostic follow-up after community-based low-dose CT screening",
"authors": "Hotta T, Hamaguchi M, Okimoto T",
"doi": "10.1016/j.resinv.2026.101518",
"type": "Peer-reviewed article",
"design": "Retrospective cohort of 3,507 abnormal low-dose CT screens in one Japanese community programme, 2010–2025, with a 1,122-examination time-to-event subcohort (2021–2025)",
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},
{
"kind": "item",
"title": "GLP-1 users with obesity and raised CRP died less often, with heart attacks unchanged",
"excerpt": "In 50,009 matched pairs with obesity and raised CRP, death, heart attack and stroke combined were lower with GLP-1 exposure (HR 0.80), almost entirely through fewer deaths (HR 0.61).",
"url": "https://www.coios.me/glp-1-use-with-raised-crp-tracked-lower-mortality-but-no/",
"published_at": "2026-09-23T13:00:01.000Z",
"updated_at": "2026-10-18T12:16:49.000Z",
"domain": "Health today",
"drivers": [
"Heart and stroke",
"Obesity, diabetes and GLP-1"
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"d-cardiovascular",
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"World"
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"world"
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1016/j.amjcard.2026.09.016",
"source": "The American Journal of Cardiology, 21 September 2026",
"paper_title": "GLP-1 Analogues and Long-term Outcomes in Adults with Obesity and Elevated CRP: A Real-world Matched Cohort Study",
"authors": "Shah S, Abusafia M, Sheashaa H, Jadam S, Ospina S, Kaelber D et al.",
"doi": "10.1016/j.amjcard.2026.09.016",
"type": "Peer-reviewed article",
"design": "Propensity-matched active-comparator cohort in the TriNetX federated EHR network, 50,009 per arm, followed up to 10 years",
"coverage": "",
"granularity": "",
"latency": "",
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"change": "",
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},
{
"kind": "item",
"title": "Aumolertinib with radiotherapy gave 34 months progression-free in EGFR-mutant lung cancer",
"excerpt": "In a trial stopped early, aumolertinib with radiotherapy gave median progression-free survival of 34.0 months against 7.4 months for chemotherapy with radiotherapy in EGFR-mutated stage III lung cancer.",
"url": "https://www.coios.me/aumolertinib-with-radiotherapy-gave-median-pfs-of-34-vs-7-4/",
"published_at": "2026-09-23T13:00:00.000Z",
"updated_at": "2026-10-18T12:16:49.000Z",
"domain": "Health today",
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"Cancer",
"AI in medicine"
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"d-cancer",
"d-ai-medicine"
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"countries": [
"China"
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"country_codes": [
"cn"
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1038/s41392-026-02891-2",
"source": "Signal Transduction and Targeted Therapy, 21 September 2026",
"paper_title": "Induction and concurrent aumolertinib with radiotherapy for EGFR-mutated stage III NSCLC: results of phase III ADVANCE trial and real-world validation",
"authors": "Bi N, Wang J, Jiang W, Fu X, Zhao L, Yang Z et al.",
"doi": "10.1038/s41392-026-02891-2",
"type": "Peer-reviewed article",
"design": "Open-label phase III randomised trial, 43 patients randomised of 98 planned, terminated at interim analysis, median follow-up 25.5 months, with a prespecified real-world cohort (n=125, median follow-up 32.7 months)",
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},
{
"kind": "item",
"title": "Swings in blood pressure between visits carry higher abdominal aortic aneurysm risk",
"excerpt": "Among 189,770 UK Biobank participants, those with the most variable systolic readings had 33% to 54% higher risk of abdominal aortic aneurysm than those with the steadiest readings.",
"url": "https://www.coios.me/variability-in-blood-pressure-tracks-aortic-aneurysm-risk/",
"published_at": "2026-09-23T12:58:00.000Z",
"updated_at": "2026-10-18T12:16:49.000Z",
"domain": "Health today",
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"What linked data reveals"
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"d-linked-data"
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"United Kingdom"
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"country_codes": [
"gb"
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://link.springer.com/article/10.1007/s10654-026-01459-2",
"source": "European Journal of Epidemiology, 23 September 2026",
"paper_title": "",
"authors": "",
"doi": "",
"type": "Peer-reviewed article",
"design": "Prospective cohort, 189,770 UK Biobank participants with linked primary care blood pressure records, median follow-up 10.7 years, 1,036 incident abdominal aortic aneurysms",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
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"reason": "",
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},
{
"kind": "item",
"title": "Exercise-based telerehabilitation raised peak oxygen uptake in cardiac patients",
"excerpt": "Telerehabilitation with exercise at its core raised peak oxygen uptake by 2.58 mL/kg/min in 13 randomised trials of 958 adults with cardiovascular disease, although the prediction interval crossed zero.",
"url": "https://www.coios.me/remote-exercise-rehabilitation-raised-peak-oxygen-uptake-in/",
"published_at": "2026-09-23T12:55:00.000Z",
"updated_at": "2026-10-18T12:16:49.000Z",
"domain": "Tomorrow's world",
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"Diet, exercise and sleep"
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"d-remote-medicine",
"d-cardiovascular",
"d-diet-activity"
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"countries": [],
"country_codes": [],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.2196/95923",
"source": "Journal of Medical Internet Research, 21 September 2026",
"paper_title": "Effects of Telerehabilitation With Exercise as the Core Component on Peak Oxygen Uptake and Blood Pressure in Patients With Cardiovascular Disease: Systematic Review and Meta-Analysis",
"authors": "Zhu Z, Fan Y, Tang Z, Song N, Mao Y, Zhu Z",
"doi": "10.2196/95923",
"type": "Peer-reviewed article",
"design": "Systematic review and meta-analysis of 13 randomised controlled trials, n=958, searched to March 2026",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
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},
{
"kind": "item",
"title": "US life expectancy ranked 38th in 2023 and the gap has widened",
"excerpt": "US life expectancy ranked 38th in 2023, with the gap against 16 high-income countries widening and rising death rates concentrated at younger and working ages.",
"url": "https://www.coios.me/us-life-expectancy-ranked-38th-in-2023-as-the-gap-with-peer/",
"published_at": "2026-09-23T12:50:00.000Z",
"updated_at": "2026-10-18T12:16:50.000Z",
"domain": "Data, models and systems",
"drivers": [
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"Alcohol and drug use"
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"countries": [
"United States"
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"country_codes": [
"us"
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1111/1468-0009.70118",
"source": "The Milbank Quarterly, 23 September 2026",
"paper_title": "US Life Expectancy and Increasing Mortality Rates: An Analysis of the Crisis",
"authors": "Woolf SH",
"doi": "10.1111/1468-0009.70118",
"type": "Peer-reviewed article",
"design": "Descriptive cross-national and cause-specific mortality analysis (US 1999–2023; 16 high-income comparators) with state-level life expectancy by gubernatorial party, 1941–2022, plus literature review",
"coverage": "",
"granularity": "",
"latency": "",
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},
{
"kind": "item",
"title": "AI models predict death after hip fracture, but external validation is inconsistent",
"excerpt": "A review of 40 studies from 2010 to 2026 found machine learning models predicting outcomes after hip fracture discriminated moderately to strongly, though external validation was inconsistent.",
"url": "https://www.coios.me/ai-models-predict-death-after-hip-fracture-but-are-seldom/",
"published_at": "2026-09-23T12:45:05.000Z",
"updated_at": "2026-10-18T12:16:50.000Z",
"domain": "Data, models and systems",
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"world"
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1007/s11914-026-00986-x",
"source": "Current Osteoporosis Reports, 22 September 2026",
"paper_title": "Artificial Intelligence and Machine Learning for Outcome Prediction After Osteoporotic Hip Fracture: A Systematic Review and Meta-analysis of Prediction Model Performance",
"authors": "Jha G, Chadalavada G, Shahid Z, Mahi G, Bishnoi A",
"doi": "10.1007/s11914-026-00986-x",
"type": "Peer-reviewed article",
"design": "PRISMA systematic review and meta-analysis of prediction model performance, 40 studies, 2010-2026",
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"latency": "",
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},
{
"kind": "item",
"title": "Whole-genome sequencing found a single-gene cause in 4.9% of kidney anomaly patients",
"excerpt": "Whole-genome sequencing of 1,052 UK 100,000 Genomes participants with congenital kidney and urinary tract anomalies found a single-gene cause in 4.9%, rising to 11.1% in those with cystic kidney dysplasia.",
"url": "https://www.coios.me/whole-genome-sequencing-gave-a-genetic-diagnosis-in-4-9-of/",
"published_at": "2026-09-23T12:45:04.000Z",
"updated_at": "2026-10-18T12:16:50.000Z",
"domain": "Data, models and systems",
"drivers": [
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"country_codes": [
"gb"
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1016/j.kint.2026.07.037",
"source": "Kidney International, 21 September 2026",
"paper_title": "Whole-genome sequencing characterizes monogenic and polygenic contributions to structural kidney and urinary tract malformations",
"authors": "Chan MMY, Sadeghi-Alavijeh O, du Preez S, Voinescu CD, van der Zanden LFM, Groen In 't Woud S et al.",
"doi": "10.1016/j.kint.2026.07.037",
"type": "Peer-reviewed article",
"design": "Whole-genome sequencing case-control analysis, 1,052 CAKUT patients in the UK 100,000 Genomes Project, with 813 cases against 25,205 ancestry-matched controls and external validation in 77 cases and 2,746 controls",
"coverage": "",
"granularity": "",
"latency": "",
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},
{
"kind": "item",
"title": "Particulate matter shows no overall association with venous thromboembolism",
"excerpt": "An updated meta-analysis of 19 observational studies covering more than 4.5 million people found no significant overall association between long-term particulate exposure and venous thromboembolism, with a modest one appearing only among studies reporting in the same units.",
"url": "https://www.coios.me/particulate-matter-shows-no-overall-association-with-venous/",
"published_at": "2026-09-23T12:45:03.000Z",
"updated_at": "2026-10-18T12:16:50.000Z",
"domain": "Tomorrow's world",
"drivers": [
"A changing climate"
],
"driver_slugs": [
"d-climate"
],
"countries": [
"World"
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"country_codes": [
"world"
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1055/a-2945-4974",
"source": "Thrombosis and Haemostasis, 21 September 2026",
"paper_title": "Ambient Particulate Matter Exposure and Risk of Venous Thromboembolism: An Updated Systematic Review and Meta-Analysis",
"authors": "Correa Lara MVM, García Chávez J, Martínez Hernández E",
"doi": "10.1055/a-2945-4974",
"type": "Peer-reviewed article",
"design": "Systematic review and random-effects meta-analysis of 19 observational studies, >4.5 million participants",
"coverage": "",
"granularity": "",
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"access": "",
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},
{
"kind": "item",
"title": "Only the intelligence part of an education genetic score tracks Alzheimer's",
"excerpt": "Across four cohorts of 3,483 participants, the intelligence-linked part of an education genetic score was inversely associated with Alzheimer's diagnosis, while the behavioural part was not.",
"url": "https://www.coios.me/only-the-cognitive-part-of-education-s-polygenic-score/",
"published_at": "2026-09-23T12:45:02.000Z",
"updated_at": "2026-10-18T12:16:50.000Z",
"domain": "Health today",
"drivers": [
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"What linked data reveals"
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"driver_slugs": [
"d-dementia",
"d-linked-data"
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"countries": [
"United States",
"United Kingdom"
],
"country_codes": [
"us",
"gb"
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1002/ana.78367",
"source": "Annals of Neurology, 22 September 2026",
"paper_title": "Genetic Resilience and Resistance in Alzheimer's Disease Diagnosis and Pathology",
"authors": "Leonenko G, Mavromati K, Hughes L, Sundarakumar JS, Brookes K, Morgan K et al.",
"doi": "10.1002/ana.78367",
"type": "Peer-reviewed article",
"design": "Polygenic score association study across four cohorts (BioHermes-1 n=770; ADNI n=1,361; ROSMAP n=841; BDR n=511), with biomarker and post-mortem outcomes",
"coverage": "",
"granularity": "",
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},
{
"kind": "item",
"title": "SGLT2 inhibitors show no new safety signals in diabetic kidney disease",
"excerpt": "In two US claims cohorts with type 2 diabetes and stage III to IV kidney disease, SGLT2 inhibitors showed only the known genital infection signal against GLP-1 receptor agonists.",
"url": "https://www.coios.me/a-claims-wide-screen-of-sglt2-inhibitors-in-kidney-disease/",
"published_at": "2026-09-23T12:45:01.000Z",
"updated_at": "2026-10-18T12:16:51.000Z",
"domain": "Health today",
"drivers": [
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"driver_slugs": [
"d-cardiovascular"
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"countries": [
"United States"
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"country_codes": [
"us"
],
"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1053/j.ajkd.2026.06.013",
"source": "American Journal of Kidney Diseases, 21 September 2026",
"paper_title": "Safety of Sodium/Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes and CKD",
"authors": "Ortega-Montiel J, Alkabbani W, Hahn G, Liu J, Byrne CF, Wexler DJ et al.",
"doi": "10.1053/j.ajkd.2026.06.013",
"type": "Peer-reviewed article",
"design": "New-user active-comparator cohort with 1:1 propensity matching and tree-based scan statistic; 22,328 matched pairs (Medicare, 2016-2020) and 8,918 (MarketScan, 2016-2022)",
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"granularity": "",
"latency": "",
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},
{
"kind": "item",
"title": "Hospitalised Brazilian influenza patients with two vaccine doses had 32% lower mortality",
"excerpt": "Among Brazilians hospitalised with influenza between 2023 and October 2025, two trivalent vaccine doses within a calendar year were associated with 32% lower in-hospital mortality and 52% fewer ICU admissions.",
"url": "https://www.coios.me/two-influenza-vaccine-doses-in-a-year-tracked-lower/",
"published_at": "2026-09-23T12:45:00.000Z",
"updated_at": "2026-10-18T12:16:51.000Z",
"domain": "Behavioural science",
"drivers": [
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"driver_slugs": [
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"countries": [
"Brazil"
],
"country_codes": [
"br"
],
"source_type": "preprint",
"verdict": "confirms",
"source_url": "https://doi.org/10.64898/2026.09.15.26362995",
"source": "medRxiv, 21 September 2026",
"paper_title": "Protective effect of influenza vaccine in Brazilian patients hospitalised for severe acute respiratory infection, 2023-2025",
"authors": "Kupek E",
"doi": "10.64898/2026.09.15.26362995",
"type": "Preprint",
"design": "Retrospective analysis of Brazilian SARI hospitalisation surveillance records, 2023 to October 2025, Poisson regression on vaccine doses received per calendar year",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
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"vintages": "",
"size": "",
"reason": "",
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},
{
"kind": "item",
"title": "Modelled 95% measles coverage in Kenya averts 879 deaths beyond current funding",
"excerpt": "A Markov model of Kenyan birth cohorts estimated that 95% coverage of both measles doses would avert 879 more deaths over ten years than maintaining current funding.",
"url": "https://www.coios.me/modelled-measles-scale-up-in-kenya-averts-879-deaths-over/",
"published_at": "2026-09-23T12:40:03.000Z",
"updated_at": "2026-10-18T12:16:51.000Z",
"domain": "Data, models and systems",
"drivers": [
"Value in health",
"Infection and pandemics",
"Health systems and access"
],
"driver_slugs": [
"d-health-economics",
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"d-health-systems"
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"countries": [
"Kenya"
],
"country_codes": [
"ke"
],
"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1371/journal.pgph.0006440",
"source": "PLOS Global Public Health, 22 September 2026",
"paper_title": "Cost-effectiveness and budget impact analyses of strategies to improve measles vaccination coverage in Kenya",
"authors": "Orangi S, Mandaliya P, Jalang'o R, Amoth P, Banda A, Anosike C et al.",
"doi": "10.1371/journal.pgph.0006440",
"type": "Peer-reviewed article",
"design": "Markov cost-effectiveness and budget-impact model, health-system perspective, annual birth cohorts, 10-year horizon, Kenya",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
"vintages": "",
"size": "",
"reason": "",
"supersedes": "",
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"attention": "",
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},
{
"kind": "item",
"title": "RSV awareness tracked with vaccination in White and Black women, not Hispanic women",
"excerpt": "Among 650 pregnant and postpartum US women, RSV awareness was associated with a 26.4 point higher vaccination probability for White women but a non-significant 6.9 points for Hispanic women.",
"url": "https://www.coios.me/rsv-awareness-raised-vaccination-odds-for-white-and-black/",
"published_at": "2026-09-23T12:40:02.000Z",
"updated_at": "2026-10-18T12:16:51.000Z",
"domain": "Behavioural science",
"drivers": [
"Infection and pandemics",
"Health systems and access"
],
"driver_slugs": [
"d-infectious-disease",
"d-health-systems"
],
"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1007/s40615-026-03168-8",
"source": "Journal of Racial and Ethnic Health Disparities, 21 September 2026",
"paper_title": "Racial and Ethnic Differences in the Association Between Maternal RSV Awareness and Vaccine Uptake",
"authors": "Olorunsaiye CZ, Hatridge G, Okusaga J, Adeleye K, Degge HM, Yusuf KK",
"doi": "10.1007/s40615-026-03168-8",
"type": "Peer-reviewed article",
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},
{
"kind": "item",
"title": "Longer stays tracked higher death and longer waits lower, a triage artefact",
"excerpt": "A retrospective analysis of 593,673 emergency presentations at a New Zealand hospital between 2016 and 2024 found longer departmental stays associated with worse outcomes and longer waiting times associated with better ones, reflecting triage order rather than any effect of waiting.",
"url": "https://www.coios.me/longer-stays-tracked-higher-death-and-longer-waits-lower-a/",
"published_at": "2026-09-23T12:40:01.000Z",
"updated_at": "2026-10-18T12:16:51.000Z",
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"countries": [
"New Zealand"
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"country_codes": [
"nz"
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1007/s10916-026-02420-2",
"source": "Journal of Medical Systems, 23 September 2026",
"paper_title": "IMPACT: Integrated Model For Patient Acuity, Care, And Triage Efficiency In Emergency Department",
"authors": "Rasouli Panah H, Ijadi Maghsoodi A, Madanian S, Yu J",
"doi": "10.1007/s10916-026-02420-2",
"type": "Peer-reviewed article",
"design": "Retrospective analysis of 593,673 emergency department presentations at one tertiary hospital, Waikato, New Zealand, 2016-2024; GLM plus regularised logistic regression",
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},
{
"kind": "item",
"title": "Projected cancer cases in sexual and gender minorities rise with self-identification",
"excerpt": "A projection applying cancer incidence rates to survey identification proportions estimated 15 times more cases at ages 55 to 59 among Millennial than Silent Generation sexual and gender minority Americans, 77,521 against 5,134 over five years, driven by who identifies rather than by risk.",
"url": "https://www.coios.me/projected-cancer-cases-in-sexual-and-gender-minorities-rise/",
"published_at": "2026-09-23T12:25:00.000Z",
"updated_at": "2026-10-17T08:15:14.000Z",
"domain": "Health today",
"drivers": [
"Cancer"
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"driver_slugs": [
"d-cancer"
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"countries": [
"United States"
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"country_codes": [
"us"
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1158/1055-9965.epi-26-0504",
"source": "Cancer Epidemiology, Biomarkers & Prevention, 22 September 2026",
"paper_title": "Projected Cancer Burden among Sexual and Gender Minorities by Generation in the United States",
"authors": "Xu CW, Mani K, Dickstein DR, Patel RK, Wang M, Xu Y et al.",
"doi": "10.1158/1055-9965.epi-26-0504",
"type": "Peer-reviewed article",
"design": "Age-period-cohort projection (Nordpred) of SEER 12-registry incidence for five cancers to 2040-2044, applied to Census population estimates and Gallup 2023-24 sexual and gender minority identification proportions",
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},
{
"kind": "item",
"title": "Varenicline users had about half the dementia rate of nicotine-replacement users",
"excerpt": "Among 1,758 matched pairs aged 50 and over in the All of Us cohort, varenicline users had about half the rate of dementia of those using nicotine replacement (HR 0.52).",
"url": "https://www.coios.me/varenicline-users-had-about-half-the-dementia-risk-of/",
"published_at": "2026-09-21T08:40:00.000Z",
"updated_at": "2026-10-18T12:16:51.000Z",
"domain": "Health today",
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"d-dementia",
"d-smoking-vaping"
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"United States"
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"us"
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"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.09.17.26363232",
"source": "medRxiv, 20 September 2026",
"paper_title": "Varenicline as a Repurposable Drug Candidate for ADRD Prevention",
"authors": "Ma P, Zhou J, Cheng Y, McGeary JE, Taveira TH, Ahmed A et al.",
"doi": "10.64898/2026.09.17.26363232",
"type": "Preprint",
"design": "Propensity-matched active-comparator cohort in All of Us, 9,584 initiators aged 50+ (1,758 matched pairs), 2006-2023",
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},
{
"kind": "item",
"title": "Consistent glucose monitor users stayed on GLP-1 drugs longer in type 2 diabetes",
"excerpt": "In US claims for adults with type 2 diabetes starting a GLP-1 drug, 68.4% of consistent glucose monitor users were still on it at one year, against 51.9% of non-users.",
"url": "https://www.coios.me/glp-1-users-with-continuous-glucose-monitoring-were-more/",
"published_at": "2026-09-21T08:39:00.000Z",
"updated_at": "2026-10-18T12:16:52.000Z",
"domain": "Health today",
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"d-obesity-diabetes"
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"United States"
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"us"
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"verdict": "new",
"source_url": "https://doi.org/10.1177/15209156261489904",
"source": "Diabetes Technology & Therapeutics, 19 September 2026",
"paper_title": "Association Between Continuous Glucose Monitoring Utilization and Glucagon-Like Peptide-1 Receptor Agonist Discontinuation in Type 2 Diabetes: A Real-World Study",
"authors": "Wright EE, Huang E, Bindal A",
"doi": "10.1177/15209156261489904",
"type": "Peer-reviewed article",
"design": "Retrospective matched-cohort study of US administrative claims (Inovalon Insights), 934 adherent CGM users matched to 3,747 non-users with type 2 diabetes starting a GLP-1 receptor agonist, 2017-2024",
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},
{
"kind": "item",
"title": "Brain-activity feedback from peers in recovery reduced craving in opioid use disorder",
"excerpt": "People with opioid use disorder were trained to match their frontal brain activity to that of peers further into recovery, and craving fell against sham feedback.",
"url": "https://www.coios.me/peer-derived-fmri-neurofeedback-during-a-film-reduced/",
"published_at": "2026-09-21T08:38:00.000Z",
"updated_at": "2026-10-18T12:16:52.000Z",
"domain": "Behavioural science",
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"Alcohol and drug use",
"Innovation in treatment"
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"d-alcohol-drugs",
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"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.09.18.26363414",
"source": "medRxiv, 20 September 2026",
"paper_title": "Peer-guided movie neurofeedback to facilitate recovery in opioid use disorder",
"authors": "Kronberg G, McClain NE, Boros M, Santhapuram S, Drury KR, Hennings AC et al.",
"doi": "10.64898/2026.09.18.26363414",
"type": "Preprint",
"design": "Two-cohort real-time fMRI neurofeedback proof-of-concept in opioid use disorder, real versus yoked sham feedback; sample size not stated",
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},
{
"kind": "item",
"title": "Parents of children with cancer report debt and long-term loss of household security",
"excerpt": "A review of 14 qualitative studies covering 524 participants in seven countries found medical costs, lost earnings and weak insurance left families in debt, with help giving only partial relief.",
"url": "https://www.coios.me/families-of-children-with-cancer-report-debt-and-a-lasting/",
"published_at": "2026-09-21T08:37:00.000Z",
"updated_at": "2026-10-18T12:16:52.000Z",
"domain": "Health today",
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1007/s00520-026-11232-6",
"source": "Supportive Care in Cancer, 20 September 2026",
"paper_title": "Financial toxicity among families of children with cancer: a qualitative systematic review and meta-aggregation",
"authors": "Yang H, Li C, Chen Q, Shu D, Lu TX, Zou H et al.",
"doi": "10.1007/s00520-026-11232-6",
"type": "Peer-reviewed article",
"design": "Qualitative systematic review with JBI meta-aggregation; 14 studies, 524 participants, seven countries, searched to May 2025",
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"granularity": "",
"latency": "",
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},
{
"kind": "item",
"title": "Lower nutrition-inflammation score went with higher mortality in ICU kidney injury",
"excerpt": "In 1,887 intensive care patients with acute kidney injury, a higher nutrition and inflammation score was associated with lower in-hospital mortality, at a hazard ratio of 0.86 per log unit.",
"url": "https://www.coios.me/a-nutrition-inflammation-index-tracked-short-term-mortality/",
"published_at": "2026-09-21T08:08:37.000Z",
"updated_at": "2026-10-18T12:16:52.000Z",
"domain": "Health today",
"drivers": [
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"countries": [
"United States"
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"us"
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1016/j.clinsp.2026.101156",
"source": "Clinics, 19 September 2026",
"paper_title": "Advanced lung cancer inflammation index is associated with mortality in critically ill patients with acute kidney injury",
"authors": "Liu Q, Zhang Y, Xia Y, Li B",
"doi": "10.1016/j.clinsp.2026.101156",
"type": "Peer-reviewed article",
"design": "Retrospective single-centre cohort using MIMIC-IV, 1,887 adult ICU patients with acute kidney injury",
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},
{
"kind": "item",
"title": "Amish study of 3,978 adults links cognitive diagnoses to pedigrees and whole-genome data",
"excerpt": "The Collaborative Amish Aging and Memory Project has enrolled 3,978 Amish adults in Ohio and Indiana, 2,928 with an agreed cognitive diagnosis, and reports only the cohort's composition.",
"url": "https://www.coios.me/an-amish-founder-population-cohort-links-genomes-and/",
"published_at": "2026-09-21T08:05:46.000Z",
"updated_at": "2026-10-18T12:16:52.000Z",
"domain": "Data, models and systems",
"drivers": [
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"What linked data reveals"
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"d-linked-data"
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"United States"
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"us"
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"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.09.17.26363351",
"source": "medRxiv",
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"authors": "",
"doi": "",
"type": "",
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"coverage": "Amish communities in Ohio and Indiana, United States; 3,978 participants, mean age 78.6; enrolment ongoing, start year not stated",
"granularity": "Individual-level clinical and cognitive assessment with consensus-adjudicated diagnosis, pedigree, genome-wide genotype, whole-genome sequencing, plasma biomarkers; repeat visits for subsets",
"latency": "not stated",
"access": "not stated",
"change": "New source",
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},
{
"kind": "item",
"title": "Machine learning predicted HPV vaccine hesitancy no better than logistic regression",
"excerpt": "Among 1,156 parents in Buea Health District, Cameroon, logistic regression, random forest and gradient boosting identified hesitant parents equally well, with area under the curve between 0.841 and 0.870.",
"url": "https://www.coios.me/gradient-boosting-did-no-better-than-logistic-regression-on/",
"published_at": "2026-09-21T08:04:46.000Z",
"updated_at": "2026-10-18T12:16:52.000Z",
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"verdict": "confirms",
"source_url": "https://doi.org/10.64898/2026.09.18.26363393",
"source": "medRxiv, 20 September 2026",
"paper_title": "Predicting parental Human papillomavirus vaccine hesitancy: development and internal validation of machine learning models",
"authors": "Alabi IO, Bekalo DB, Kartsonaki C, Agbor VN",
"doi": "10.64898/2026.09.18.26363393",
"type": "Preprint",
"design": "Secondary analysis of a cross-sectional survey of 1,156 parents in Buea Health District, Cameroon; 80/20 split, internal validation only",
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},
{
"kind": "item",
"title": "Glial injury marker GFAP separates Alzheimer's stages more sharply than vascular markers",
"excerpt": "Among 2650 ADNI participants, the glial injury marker GFAP was 56.3% higher in Alzheimer's dementia than in unimpaired people, whereas vascular markers differed by around 14% and discriminated poorly.",
"url": "https://www.coios.me/plasma-gfap-separated-alzheimer-s-stages-while-vascular/",
"published_at": "2026-09-21T08:04:26.000Z",
"updated_at": "2026-10-18T12:16:53.000Z",
"domain": "Health today",
"drivers": [
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"d-dementia"
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"United States"
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"country_codes": [
"us"
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1096/fba.2026-00194",
"source": "FASEB BioAdvances, 19 September 2026",
"paper_title": "Glial and Vascular Plasma Biomarkers Across the Alzheimer's Disease Continuum: An ADNI-Based Longitudinal Study",
"authors": "Jahanbin K, Alzheimer's Disease Neuroimaging Initiative",
"doi": "10.1096/fba.2026-00194",
"type": "Peer-reviewed article",
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},
{
"kind": "item",
"title": "Wastewater bacteria tracked community COVID-19 case rates alongside viral load",
"excerpt": "A preprint reports that gut bacteria depleted during infection tracked COVID-19 case rates in wastewater, with bacteria alone predicting future rates modestly better than bacteria plus viral gene copies.",
"url": "https://www.coios.me/bacteria-in-wastewater-tracked-community-covid-19-rates/",
"published_at": "2026-09-21T08:02:31.000Z",
"updated_at": "2026-10-18T12:16:53.000Z",
"domain": "Behavioural science",
"drivers": [
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"countries": [],
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"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.09.16.26363250",
"source": "medRxiv, 20 September 2026",
"paper_title": "Microbiome signature in wastewater is predictive of COVID-19 case rates",
"authors": "Schroeder TA, Basting CM, Swanson E, Bailey M, Champeau SR, Velez A et al.",
"doi": "10.64898/2026.09.16.26363250",
"type": "Preprint",
"design": "Observational wastewater metagenomic study of treatment-plant samples with regression models against community COVID-19 case rates; sample size and period not stated in abstract",
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},
{
"kind": "item",
"title": "Mass cholera vaccination in Uvira, DRC, averted an estimated 56% of infections",
"excerpt": "Modelling of cholera surveillance in Uvira, Democratic Republic of the Congo, estimates that the 2020 vaccination campaign averted 56% of infections and deaths over the following three years.",
"url": "https://www.coios.me/uvira-s-2020-cholera-vaccination-campaign-averted-an/",
"published_at": "2026-09-21T08:02:14.000Z",
"updated_at": "2026-10-18T12:16:53.000Z",
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"source_url": "https://doi.org/10.64898/2026.09.17.26363298",
"source": "medRxiv, 20 September 2026",
"paper_title": "Impact of mass oral cholera vaccination in an endemic area of the Democratic Republic of the Congo: a surveillance-based counterfactual modeling analysis",
"authors": "Perez-Saez J, Malembaka EB, Bouman JA, Bugeme PM, Hutchins C, Jackson J et al.",
"doi": "10.64898/2026.09.17.26363298",
"type": "Preprint",
"design": "Surveillance-based Bayesian counterfactual transmission modelling, Uvira, DRC, Jan 2017–Dec 2023, around a 2020 campaign reaching 66% single-dose coverage",
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},
{
"kind": "item",
"title": "Spleen uptake on cardiac PET stress scans is associated with later cardiac events",
"excerpt": "Among 16,650 patients having drug-stress cardiac PET at six sites, a high ratio of spleen uptake under stress to uptake at rest was associated with more major cardiovascular events.",
"url": "https://www.coios.me/an-automated-splenic-measure-on-cardiac-pet-tracked-later/",
"published_at": "2026-09-21T08:01:58.000Z",
"updated_at": "2026-10-18T12:16:53.000Z",
"domain": "Health today",
"drivers": [
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"AI in medicine"
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"United States"
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"country_codes": [
"us"
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1093/cvr/cvag184",
"source": "Cardiovascular Research, 19 September 2026",
"paper_title": "Artificial intelligence-derived splenic response in cardiac positron emission tomography is associated with major adverse cardiovascular events: a multi-site study",
"authors": "Ramirez G, Dharmavaram NL, Shanbhag A, Miller RJH, Kavanagh PB, Yi J et al.",
"doi": "10.1093/cvr/cvag184",
"type": "Peer-reviewed article",
"design": "Retrospective multicentre cohort, 16,650 patients at six REFINE PET registry sites, median follow-up 3.4 years",
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},
{
"kind": "item",
"title": "Bempedoic acid cut LDL cholesterol by 17.5% in German lipid clinics",
"excerpt": "In 641 patients at seven German lipid clinics, mean LDL cholesterol fell by 17.5% three months after bempedoic acid was added, and 26.7% had stopped the drug by then.",
"url": "https://www.coios.me/bempedoic-acid-cut-ldl-c-17-5-in-routine-use-and-a-quarter/",
"published_at": "2026-09-21T08:00:36.000Z",
"updated_at": "2026-10-18T12:16:53.000Z",
"domain": "Health today",
"drivers": [
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"Innovation in treatment"
],
"driver_slugs": [
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"d-treatment-innovation"
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"countries": [
"Germany"
],
"country_codes": [
"de"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1186/s12944-026-03062-6",
"source": "Lipids in Health and Disease, 19 September 2026",
"paper_title": "Real-world use of bempedoic acid for hypercholesterolaemia: a German multicentre, retrospective, cohort study",
"authors": "Haberbosch L, Baessler A, de Ruiter U, Sinning D, Katzmann JL, Könemann S et al.",
"doi": "10.1186/s12944-026-03062-6",
"type": "Peer-reviewed article",
"design": "Retrospective cohort, 641 patients at 7 German lipid clinics, LDL-C before and ~3 months after starting bempedoic acid",
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},
{
"kind": "item",
"title": "Slow restart of blood pressure drugs carried higher cardiovascular risk in SPRINT",
"excerpt": "In the SPRINT trial, participants whose blood pressure drugs were reduced and not promptly restored under the standard target had a 34% higher rate of major cardiovascular events.",
"url": "https://www.coios.me/slow-restart-after-cutting-blood-pressure-drugs-tracked/",
"published_at": "2026-09-21T08:00:23.000Z",
"updated_at": "2026-10-18T12:16:53.000Z",
"domain": "Health today",
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"source_url": "https://doi.org/10.1007/s40292-026-00822-4",
"source": "High Blood Pressure & Cardiovascular Prevention, 19 September 2026",
"paper_title": "The Impact of Antihypertensive De-escalation: A Secondary Analysis of Systolic Blood Pressure Intervention Trial (SPRINT)",
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"source_url": "https://doi.org/10.1007/s00402-026-06511-0",
"source": "Archives of Orthopaedic and Trauma Surgery, 18 September 2026",
"paper_title": "Management and outcome of displaced acetabular fractures in the oldest-old: a retrospective analysis of orif and acute total hip arthroplasty",
"authors": "Mamoutakis I, Horst K, Alabdulrahman H, Groven RVM, Bläsius FM, Hildebrand F et al.",
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{
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"title": "Rare damaging variants link IMPA2 to dementia and ANKRD27 to Parkinson's disease",
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"source": "medRxiv, 18 September 2026",
"paper_title": "Population-scale burden analysis of rare damaging coding variants identifies novel risk genes for Alzheimer’s disease and related dementias and Parkinson’s disease and related disorders",
"authors": "Le Guen Y, Peña-Tauber A, Catoia Pulgrossi R, Park J, Orias H, Greicius MD",
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"kind": "item",
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"source_url": "https://doi.org/10.1016/j.mayocp.2026.08.023",
"source": "Mayo Clinic Proceedings, 18 September 2026",
"paper_title": "Healthy Lifestyle, Genetic Susceptibility and Risk of Kidney Stone Disease in the UK Biobank: A Prospective Cohort Study",
"authors": "Xu K, Yao Z, Wang Y, Na L, Liu J, Xia Y et al.",
"doi": "10.1016/j.mayocp.2026.08.023",
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{
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"title": "Telehealth-supported hepatitis C care was modelled to cost 69% less than specialist care",
"excerpt": "A cost model of the Cherokee Nation's hepatitis C programme, in which specialists advised primary care providers by video, put care at $1412 per patient against $4534 under specialist-based care.",
"url": "https://www.coios.me/telehealth-supported-hepatitis-c-care-was-costed-at-69/",
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"source_url": "https://doi.org/10.1097/phh.0000000000002487",
"source": "Journal of Public Health Management & Practice, 18 September 2026",
"paper_title": "Cost Savings Modeling of Integrated Telehealth Services for Hepatitis C Virus Infection-Cherokee Nation, 2016-2020",
"authors": "Mera J, Feder M, Sawyer J, Greene G, Wirth A, Leston J",
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"source_url": "https://doi.org/10.1016/j.jad.2026.122494",
"source": "Journal of Affective Disorders, 18 September 2026",
"paper_title": "A smartphone-based serious game to improve mental health and medication adherence in adults with depression: A randomised controlled trial",
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"title": "Quit rates at Hong Kong cessation services halved after COVID-19 emergency measures",
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"url": "https://www.coios.me/quit-rates-halved-in-hong-kong-cessation-services-after/",
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"source_url": "https://doi.org/10.1136/tc-2025-059954",
"source": "Tobacco Control, 18 September 2026",
"paper_title": "Association of early-stage COVID-19 policy changes with smoking cessation outcomes: secondary analysis of two randomised trials in Hong Kong",
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"kind": "item",
"title": "Same naloxone increase is projected to cut overdose deaths unevenly across six counties",
"excerpt": "A simulation calibrated to six Pennsylvania counties projected that the same 30% rise in naloxone distribution would cut 2029 overdose deaths by 70% in Allegheny but 11% in Erie.",
"url": "https://www.coios.me/the-same-naloxone-increase-is-modelled-to-save-six-times/",
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"source_url": "https://doi.org/10.64898/2026.05.11.26352900",
"source": "medRxiv, 18 September 2026",
"paper_title": "County-Level Heterogeneity in Opioid Harm Reduction and Treatment Effects: A Simulation Modeling Analysis",
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"attention": "1 citation (Crossref) · as of 2026-10-19",
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"kind": "item",
"title": "Shared genetic risk across cancers sits in specific regions, not across the genome",
"excerpt": "Across 16 cancers, genome-wide analysis identified 20 correlated cancer pairs, whereas analysis region by region identified shared genetic signals across 66 pairs.",
"url": "https://www.coios.me/shared-genetic-risk-across-cancers-appears-only-in-specific/",
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"source_url": "https://doi.org/10.1371/journal.pgen.1012308",
"source": "PLOS Genetics, 18 September 2026",
"paper_title": "Identifying shared polygenic risk across cancers",
"authors": "Hu J, Muheyati M, Xu L, DeWan A, Zhao H",
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"kind": "item",
"title": "Cancer risk in treated HIV followed age and smoking, not immune status",
"excerpt": "Among 7507 people with HIV on antiretroviral therapy, 219 cancers occurred over a median 5.6 years, with older age and current smoking associated with risk but immune markers not.",
"url": "https://www.coios.me/cancer-ran-at-5-6-per-1000-person-years-in-treated-hiv/",
"published_at": "2026-09-20T09:36:42.000Z",
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"source_url": "https://doi.org/10.1097/qad.0000000000004625",
"source": "AIDS, 18 September 2026",
"paper_title": "Cancer incidence and risk factors among people with HIV in REPRIEVE",
"authors": "Zhao S, McCallum S, Awwad A, Castle PE, Diggs MR, Zanni MV et al.",
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"kind": "item",
"title": "Type 2 diabetes fell by a quarter among Australian sleeve gastrectomy patients",
"excerpt": "Among 34,738 adults undergoing sleeve gastrectomy in New South Wales from 2017 to 2022, type 2 diabetes prevalence fell by 24.4%, and 72.3% had at least one cardiovascular risk factor.",
"url": "https://www.coios.me/type-2-diabetes-fell-by-a-quarter-among-australian-sleeve/",
"published_at": "2026-09-20T09:36:21.000Z",
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"source_url": "https://doi.org/10.1016/j.hlc.2026.05.018",
"source": "Heart, Lung and Circulation, 18 September 2026",
"paper_title": "Cardiovascular Risk, Comorbidity and Frailty in Patients Undergoing Sleeve Gastrectomy: A Population-Based Study",
"authors": "Goubar T, Goubar C, Fenton-Lee D, Stefanidis A, Macdonald P, Rushworth RL",
"doi": "10.1016/j.hlc.2026.05.018",
"type": "Peer-reviewed article",
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"kind": "item",
"title": "Three Holter ECG measures with age predicted five-year mortality in Israeli adults",
"excerpt": "A random forest combining atrial fibrillation burden, premature ventricular contraction burden, T-wave alternans and age reached an AUROC of 0.79 for five-year mortality in 54,395 Israeli primary care patients.",
"url": "https://www.coios.me/three-holter-ecg-markers-with-age-predicted-5-year/",
"published_at": "2026-09-20T09:36:03.000Z",
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"source_url": "https://doi.org/10.1088/1361-6579/aea9ec",
"source": "Physiological Measurement, 18 September 2026",
"paper_title": "Single-lead ECG biomarkers for cardiovascular and mortality risk prediction",
"authors": "Attali L, Solewicz Y, Brimer Biton S, Hamami H, Zvuloni E, Green I et al.",
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"type": "Peer-reviewed article",
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"kind": "item",
"title": "Illicit cigarettes rose from 8.5% to 20.4% in eight Mexican cities by 2023",
"excerpt": "In the eight Mexican cities surveyed in both years, illicit cigarettes rose from 8.5% of discarded packs in 2017 to 20.4% in 2023.",
"url": "https://www.coios.me/illicit-cigarettes-rose-from-8-5-to-20-4-of-packs-in-eight/",
"published_at": "2026-09-20T09:35:49.000Z",
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"source_url": "https://doi.org/10.1136/tc-2026-060107",
"source": "Tobacco Control, 18 September 2026",
"paper_title": "Mexican illicit cigarette market in 2023: a follow-up study",
"authors": "Saenz-de-Miera B, Reynales-Shigematsu LM, Mendez Gomez-Humaran I, Grilo G, Welding K",
"doi": "10.1136/tc-2026-060107",
"type": "Peer-reviewed article",
"design": "Repeated cross-sectional discarded-pack collection, 12,607 packs, 126 sampling areas, 11 cities, 2023 vs 2017",
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"kind": "item",
"title": "Model trained to forecast patient records predicts five-year risk of a first cancer",
"excerpt": "A model trained to forecast what happens next in the records of millions of patients predicted a first cancer within five years, although no accuracy figures are given.",
"url": "https://www.coios.me/a-generative-model-of-patient-records-stratifies-five-year/",
"published_at": "2026-09-20T09:34:46.000Z",
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"domain": "Data, models and systems",
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"source_url": "https://doi.org/10.64898/2026.09.09.26362676",
"source": "medRxiv, 19 September 2026",
"paper_title": "Identifying cohorts at elevated risk of cancers using generative modeling of patient health states",
"authors": "Khan A, Forster DT, Harsh M, Zheng C, Warner ET, Ritter D et al.",
"doi": "10.64898/2026.09.09.26362676",
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"design": "Retrospective development and validation of a generative EHR foundation model (GenEHR) with supervised adaptation, five large EHR cohorts, millions of patients, five-year horizon",
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"kind": "item",
"title": "RSV hospitalisations in older Brazilians rose after 2020, with 21-31% dying in hospital",
"excerpt": "Recorded hospitalisations for RSV among Brazilians aged 60 and over rose from under 1 to over 15 per 100,000 between 2013 and 2024, with the sharpest rise after 2020.",
"url": "https://www.coios.me/rsv-hospitalisations-in-older-brazilians-rose-after-2020/",
"published_at": "2026-09-20T09:34:21.000Z",
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"source_url": "https://doi.org/10.1371/journal.pone.0357303",
"source": "PLOS One, 18 September 2026",
"paper_title": "Burden of respiratory syncytial virus (RSV) hospitalizations among adults aged 60 years or more in Brazil: A retrospective surveillance database analysis (2013-2024)",
"authors": "de Veras BMG, Michelin L, Croda J, Berra TZ, Pires-Matheus G, Sampietri I et al.",
"doi": "10.1371/journal.pone.0357303",
"type": "Peer-reviewed article",
"design": "Retrospective analysis of national SARI surveillance records (SIVEP-Gripe), 4,636 RSV-associated hospitalisations in adults aged 60+, Brazil, 2013-2024",
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"attention": "1 citation (Crossref) · as of 2026-10-09",
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"kind": "item",
"title": "PSA density separates later prostate cancer risk after a negative screening MRI",
"excerpt": "Among 1,685 men with a negative screening MRI, seven-year incidence of significant prostate cancer was 5.5% below a PSA density of 0.10 ng/mL2 and more than double that above it.",
"url": "https://www.coios.me/psa-density-stratifies-later-significant-prostate-cancer/",
"published_at": "2026-09-20T09:34:10.000Z",
"updated_at": "2026-10-18T12:16:56.000Z",
"domain": "Health today",
"drivers": [
"Cancer"
],
"driver_slugs": [
"d-cancer"
],
"countries": [
"Sweden"
],
"country_codes": [
"se"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1111/bju.70450",
"source": "BJU International, 18 September 2026",
"paper_title": "The role of PSA density in the follow up of men with a negative MRI in the Göteborg-2 trial",
"authors": "Möller F, Månsson M, Hellström M, Langkilde F, Spyratou V, Stranne J et al.",
"doi": "10.1111/bju.70450",
"type": "Peer-reviewed article",
"design": "Pre-specified sub-analysis of the population-based randomised Göteborg-2 screening trial; 1685 men with a negative initial MRI, PSA testing 2015-2021, follow-up to September 2024 (median 5.5 years)",
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},
{
"kind": "item",
"title": "Scotland's strep A surge brought no new variant of the dominant strain",
"excerpt": "Scottish national surveillance of 3,408 invasive strep A infections found the late-2022 surge coincided with influenza and RSV, with isolates of the dominant strain type unchanged from before the pandemic.",
"url": "https://www.coios.me/scotland-s-post-pandemic-invasive-strep-a-surge-involved-no/",
"published_at": "2026-09-20T09:34:02.000Z",
"updated_at": "2026-10-18T12:16:56.000Z",
"domain": "Behavioural science",
"drivers": [
"Infection and pandemics"
],
"driver_slugs": [
"d-infectious-disease"
],
"countries": [
"United Kingdom"
],
"country_codes": [
"gb"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1016/j.jinf.2026.106860",
"source": "Journal of Infection, 18 September 2026",
"paper_title": "Clinical and population genomic epidemiology of invasive group A streptococcus in Scotland, 2014-2024",
"authors": "Beres SB, Pagnossin D, Olsen RJ, Long SW, Graviss EA, Williams T et al.",
"doi": "10.1016/j.jinf.2026.106860",
"type": "Peer-reviewed article",
"design": "National surveillance of 3,408 invasive group A streptococcus infections in Scotland 2014-2024, with hybrid whole-genome sequencing of 404 emm1 isolates",
"coverage": "",
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"latency": "",
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},
{
"kind": "item",
"title": "Norwegian stroke rates fell over 20 years, except strokes linked to atrial fibrillation",
"excerpt": "Across 227,575 strokes in Norway from 2001 to 2021, ischaemic stroke fell from 204.4 to 130.8 per 100,000 person-years in people without atrial fibrillation, but not in those with it.",
"url": "https://www.coios.me/norway-s-ischaemic-stroke-fall-over-two-decades-left-af/",
"published_at": "2026-09-20T09:33:50.000Z",
"updated_at": "2026-10-18T12:16:57.000Z",
"domain": "Health today",
"drivers": [
"Heart and stroke"
],
"driver_slugs": [
"d-cardiovascular"
],
"countries": [
"Norway"
],
"country_codes": [
"no"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1161/jaha.126.049696",
"source": "Journal of the American Heart Association, 18 September 2026",
"paper_title": "Trends in Incidence of Atrial Fibrillation-Related Stroke: The Norwegian AFNOR Study",
"authors": "Anjum M, Ariansen I, Hjellvik V, Igland J, Kjerpeseth LJ, Kvalvaag E et al.",
"doi": "10.1161/jaha.126.049696",
"type": "Peer-reviewed article",
"design": "Nationwide registry cohort, Norway 2001-2021, 227 575 incident strokes",
"coverage": "",
"granularity": "",
"latency": "",
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},
{
"kind": "item",
"title": "Atrial fibrillation recurrence after ablation was similar on GLP-1, SGLT2 or both",
"excerpt": "Among adults having catheter ablation for atrial fibrillation, recurrence was similar on a GLP-1 drug, an SGLT2 inhibitor or both, while all-cause mortality was lower on the combination.",
"url": "https://www.coios.me/combined-glp-1-and-sglt2-use-was-linked-to-lower-mortality/",
"published_at": "2026-09-20T00:09:51.000Z",
"updated_at": "2026-10-18T12:16:57.000Z",
"domain": "Health today",
"drivers": [
"Heart and stroke",
"Obesity, diabetes and GLP-1"
],
"driver_slugs": [
"d-cardiovascular",
"d-obesity-diabetes"
],
"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1016/j.hrthm.2026.09.018",
"source": "Heart Rhythm, 17 September 2026",
"paper_title": "The Effect of Glucagon-Like Peptide-1 Receptor Agonists versus Sodium-Glucose Cotransporter-2 Inhibitors Alone and in Combination on AF Recurrence and Cardiovascular Outcomes after Catheter Ablation for Atrial Fibrillation",
"authors": "Ramadan A, Doma M, Yazdanpanah MH, Naeem F, Ptaszek LM, Ruskin JN",
"doi": "10.1016/j.hrthm.2026.09.018",
"type": "Peer-reviewed article",
"design": "Retrospective propensity-matched cohort in the TriNetX federated records network, 2018-2024; matched pairs of 952-1,393 adults undergoing catheter ablation for atrial fibrillation",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
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},
{
"kind": "item",
"title": "Heart-type fatty acid-binding protein detects coronary disease poorly but tracks deaths",
"excerpt": "Heart-type fatty acid-binding protein detected coronary disease poorly in 2,690 patients, but eight-year mortality rose from 7.7% in the lowest quartile of the marker to 44% in the highest.",
"url": "https://www.coios.me/h-fabp-discriminated-coronary-disease-poorly-auc-0-56-but/",
"published_at": "2026-09-20T00:09:38.000Z",
"updated_at": "2026-10-18T12:16:57.000Z",
"domain": "Health today",
"drivers": [
"Heart and stroke"
],
"driver_slugs": [
"d-cardiovascular"
],
"countries": [],
"country_codes": [],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1016/j.cca.2026.121346",
"source": "Clinica Chimica Acta, 17 September 2026",
"paper_title": "Diagnostic and prognostic performance of heart-type fatty acid-binding protein in functionally relevant coronary artery disease",
"authors": "Tsianakas E, Kul S, Nafaa F, Durak K, Lopez-Ayala P, Kaplan E et al.",
"doi": "10.1016/j.cca.2026.121346",
"type": "Peer-reviewed article",
"design": "Prospective diagnostic cohort with central adjudication by perfusion imaging and angiography, n=2690 diagnostic and n=2645 prognostic, 8-year follow-up",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
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"size": "",
"reason": "",
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"attention": "",
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"corrected": ""
},
{
"kind": "item",
"title": "Adolescent movement behaviours explained 2.0 points of a 6.9-point CVD risk gap",
"excerpt": "In 6,608 US adolescents followed for over two decades, the 6.9 percentage-point gap in predicted 30-year cardiovascular risk by parental education fell to 4.9 points in a scenario removing all unhealthy physical activity, screen time and sleep, and the relative gap was unchanged.",
"url": "https://www.coios.me/adolescent-movement-behaviours-explained-2-0-points-of-a-6/",
"published_at": "2026-09-20T00:09:31.000Z",
"updated_at": "2026-10-18T12:16:57.000Z",
"domain": "Behavioural science",
"drivers": [
"Diet, exercise and sleep",
"Health systems and access"
],
"driver_slugs": [
"d-diet-activity",
"d-health-systems"
],
"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1093/aje/kwag234",
"source": "American Journal of Epidemiology, 18 September 2026",
"paper_title": "Contribution of Adolescent Movement Behaviours to Socioeconomic Inequalities in Adult Cardiovascular Disease Risk: A Causal Decomposition in a Population-Based Cohort",
"authors": "Grubic N, Maximova K, Chiolero A, Siddiqi A, Carsley S, Batomen B et al.",
"doi": "10.1093/aje/kwag234",
"type": "Peer-reviewed article",
"design": "Causal decomposition (g-formula) in the Add Health cohort, n=6,608, enrolled 1994-95 and followed to 2016-18",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
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"reason": "",
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},
{
"kind": "item",
"title": "GLP-1/GIP agonist BGM0504 reduced weight by up to 18% at 24 weeks",
"excerpt": "In 120 Chinese adults with overweight or obesity and no diabetes, weekly BGM0504 reduced weight by 10.7% to 18.3% at 24 weeks, as compared to no change on placebo.",
"url": "https://www.coios.me/a-chinese-dual-glp-1-gip-agonist-produced-11-to-18-weight/",
"published_at": "2026-09-20T00:09:22.000Z",
"updated_at": "2026-10-18T12:16:57.000Z",
"domain": "Health today",
"drivers": [
"Obesity, diabetes and GLP-1"
],
"driver_slugs": [
"d-obesity-diabetes"
],
"countries": [
"China"
],
"country_codes": [
"cn"
],
"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1111/dom.71193",
"source": "Diabetes, Obesity and Metabolism, 17 September 2026",
"paper_title": "Effectiveness, Safety and Pharmacokinetics of BGM0504, a Dual GLP-1/GIP Receptor Agonist, in Chinese Adults With Overweight or Obesity Without Diabetes: A Phase 2 Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial",
"authors": "Ji L, Yang G, Huang Y, Ding H, Xie D, Jiang X et al.",
"doi": "10.1111/dom.71193",
"type": "Peer-reviewed article",
"design": "Phase 2 randomised double-blind placebo-controlled trial, n=120, 24 weeks, four arms",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
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"attention": "",
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},
{
"kind": "item",
"title": "Familial adenomatous polyposis found by screening matches general population mortality",
"excerpt": "Relatives found by family screening to have familial adenomatous polyposis had mortality comparable to the general population (median SMR 0.66), against 11.09 for patients presenting with symptoms.",
"url": "https://www.coios.me/fap-relatives-found-by-family-screening-had-a-median-smr-of/",
"published_at": "2026-09-20T00:08:57.000Z",
"updated_at": "2026-10-18T12:16:57.000Z",
"domain": "Health today",
"drivers": [
"Cancer"
],
"driver_slugs": [
"d-cancer"
],
"countries": [
"United Kingdom"
],
"country_codes": [
"gb"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.14309/ajg.0000000000004205",
"source": "American Journal of Gastroenterology, 18 September 2026",
"paper_title": "Life expectancy and changing causes of mortality in familial adenomatous polyposis (FAP)",
"authors": "Zare B, Clark SK, Latchford A",
"doi": "10.14309/ajg.0000000000004205",
"type": "Peer-reviewed article",
"design": "Retrospective life-table and cause-of-death analysis of a prospective FAP registry, 1917 patients born after 1935, 364 deaths",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
"vintages": "",
"size": "",
"reason": "",
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},
{
"kind": "item",
"title": "Blood p-tau217 tracked Alzheimer's-type brain shrinkage but not ordinary ageing",
"excerpt": "Among 818 adults with no cognitive symptoms in the Baltimore Longitudinal Study of Aging, p-tau217 was the only blood marker associated with later shrinkage of the medial temporal lobe.",
"url": "https://www.coios.me/plasma-p-tau217-tracked-alzheimer-s-type-atrophy-but-not/",
"published_at": "2026-09-20T00:08:46.000Z",
"updated_at": "2026-10-18T12:16:58.000Z",
"domain": "Health today",
"drivers": [
"Dementia"
],
"driver_slugs": [
"d-dementia"
],
"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "preprint",
"verdict": "refines",
"source_url": "https://doi.org/10.64898/2026.09.11.26362869",
"source": "medRxiv, 17 September 2026",
"paper_title": "Association of plasma biomarkers with longitudinal change in age- and Alzheimer’s disease-related brain atrophy patterns",
"authors": "Bilgel M, Shah I, Cooper J, An Y, Walker KA, Ho SG et al.",
"doi": "10.64898/2026.09.11.26362869",
"type": "Preprint",
"design": "Prospective cohort, Baltimore Longitudinal Study of Aging: 818 cognitively unimpaired adults, 2,293 serial MRIs, 104 conversions to MCI/dementia",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
"vintages": "",
"size": "",
"reason": "",
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},
{
"kind": "item",
"title": "Enriched Head Start preschool improved 7 of 11 well-being measures by age 21",
"excerpt": "Adding intensive social-emotional and language support to Head Start classrooms improved 7 of 11 well-being measures at ages 21 to 22, in a randomised trial of 356 children.",
"url": "https://www.coios.me/an-enriched-head-start-programme-improved-7-of-11-well/",
"published_at": "2026-09-20T00:08:28.000Z",
"updated_at": "2026-10-18T12:16:58.000Z",
"domain": "Behavioural science",
"drivers": [
"Social connection"
],
"driver_slugs": [
"d-social-connection"
],
"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1037/amp0001765",
"source": "American Psychologist, 17 September 2026",
"paper_title": "Promoting resilience with social-emotional learning: Young adult follow-up of a preschool randomized-controlled trial",
"authors": "Bierman KL, Heinrichs BS, Welsh JA, Jones DE, Crowley DM",
"doi": "10.1037/amp0001765",
"type": "Peer-reviewed article",
"design": "Randomised controlled trial of enriched Head Start preschool, n=356 children enrolled at mean age 4.5, followed to ages 21-22",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
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"reason": "",
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},
{
"kind": "item",
"title": "A model puts daraxonrasib at $500,637 per quality-adjusted life year in pancreatic cancer",
"excerpt": "A cost-effectiveness model built from the RASolute 302 trial put daraxonrasib at $500,637 per quality-adjusted life year gained over chemotherapy, at a US price of $39,800 per 30 days.",
"url": "https://www.coios.me/daraxonrasib-is-estimated-at-500-637-per-qaly-in-pancreatic/",
"published_at": "2026-09-20T00:08:13.000Z",
"updated_at": "2026-10-18T12:16:58.000Z",
"domain": "Health today",
"drivers": [
"Cancer",
"Value in health",
"Innovation in treatment"
],
"driver_slugs": [
"d-cancer",
"d-health-economics",
"d-treatment-innovation"
],
"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.09.16.26363246",
"source": "medRxiv, 17 September 2026",
"paper_title": "Cost-Effectiveness of Daraxonrasib vs Chemotherapy in Previously Treated Metastatic Pancreatic Adenocarcinoma",
"authors": "Han S, Starasvetskaya N, Terrero G, Hosein PJ, de Lima Lopes G",
"doi": "10.64898/2026.09.16.26363246",
"type": "Preprint",
"design": "Partitioned survival cost-effectiveness model using reconstructed patient data from the phase 3 RASolute 302 trial (RAS G12 n=459; full randomised n=500), US health sector perspective, 2026 dollars",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
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"size": "",
"reason": "",
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},
{
"kind": "item",
"title": "Cancer polygenic scores were weaker in African-ancestry than European-ancestry veterans",
"excerpt": "Across 560,287 US veterans, all 13 cancer polygenic scores were associated with their own cancer in European-ancestry participants, but only five of 13 were in African-ancestry participants.",
"url": "https://www.coios.me/cancer-polygenic-scores-were-weaker-in-african-ancestry/",
"published_at": "2026-09-20T00:08:03.000Z",
"updated_at": "2026-10-18T12:16:58.000Z",
"domain": "Health today",
"drivers": [
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"What linked data reveals"
],
"driver_slugs": [
"d-cancer",
"d-linked-data"
],
"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1200/po-25-00957",
"source": "JCO Precision Oncology, 17 September 2026",
"paper_title": "Cross-Ancestry and Phenome-Wide Associations of Cancer-Specific Polygenic Risk Scores",
"authors": "Wang L, Desai H, Teerlink C, Clark O, Pridgen KM, Lee J et al.",
"doi": "10.1200/po-25-00957",
"type": "Peer-reviewed article",
"design": "Cross-sectional association study of 13 cancer polygenic risk scores against 340 phecodes in 560,287 Million Veteran Program participants (114,255 African ancestry, 446,032 European ancestry)",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
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"vintages": "",
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"reason": "",
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"attention": "",
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},
{
"kind": "item",
"title": "Women and deprived patients had higher one-year mortality in English aortic disease",
"excerpt": "Among 33,793 new thoracic aortic disease diagnoses in England between 2013 and 2018, one-year mortality was higher among women, older patients and those from deprived areas, and patients from deprived areas were less likely to receive early intervention or genetic referral.",
"url": "https://www.coios.me/women-and-deprived-patients-had-higher-one-year-mortality/",
"published_at": "2026-09-20T00:07:45.000Z",
"updated_at": "2026-10-18T12:16:58.000Z",
"domain": "Health today",
"drivers": [
"Heart and stroke",
"Health systems and access"
],
"driver_slugs": [
"d-cardiovascular",
"d-health-systems"
],
"countries": [
"United Kingdom"
],
"country_codes": [
"gb"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1161/jaha.125.047851",
"source": "Journal of the American Heart Association, 18 September 2026",
"paper_title": "Interactions Between Health Inequalities on the Management and Outcomes of Thoracic Aortic Disease in England: A National Cohort Study",
"authors": "Abbasciano RG, Miksza J, Dionne JC, Oczkowski S, Barwell J, Shannon N et al.",
"doi": "10.1161/jaha.125.047851",
"type": "Peer-reviewed article",
"design": "National cohort of 33 793 new thoracic aortic disease diagnoses in English hospitals, 2013–2018, with 1-year follow-up",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
"vintages": "",
"size": "",
"reason": "",
"supersedes": "",
"superseded_by": "",
"attention": "1 citation (Crossref) · as of 2026-10-18",
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"corrected": ""
},
{
"kind": "item",
"title": "One in five Black US students left the suicide attempt question blank",
"excerpt": "Across 163,489 US high school students surveyed from 2001 to 2021, the suicide attempt question was left blank by 21.6% of Black adolescents and 7.1% of white adolescents.",
"url": "https://www.coios.me/1-in-4-black-us-students-left-a-suicide-injury-survey-item/",
"published_at": "2026-09-20T00:07:19.000Z",
"updated_at": "2026-10-18T12:16:58.000Z",
"domain": "Health today",
"drivers": [
"Mental health"
],
"driver_slugs": [
"d-mental-health"
],
"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1016/j.puhe.2026.106497",
"source": "Public Health, 17 September 2026",
"paper_title": "Trends in missing responses to suicide-related indicators among U.S. adolescents by race/ethnicity and sex, 2001-2021",
"authors": "Vélez-Grau C, Romanelli M, Baiden P, Lindsey MA",
"doi": "10.1016/j.puhe.2026.106497",
"type": "Peer-reviewed article",
"design": "Trend analysis of repeated cross-sectional national surveys, Youth Risk Behavior Survey 2001-2021, N = 163,489 US high school students",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
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"vintages": "",
"size": "",
"reason": "",
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"attention": "",
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},
{
"kind": "item",
"title": "Cochrane review pools 107 trials of exercise rehabilitation in coronary heart disease",
"excerpt": "An updated Cochrane review pooled 107 randomised trials in 26,886 adults with coronary heart disease, comparing exercise-based rehabilitation with no exercise on death, infarction and hospital admission.",
"url": "https://www.coios.me/updated-cochrane-review-of-exercise-based-cardiac/",
"published_at": "2026-09-20T00:06:45.000Z",
"updated_at": "2026-10-23T06:05:33.000Z",
"domain": "Health today",
"drivers": [
"Heart and stroke"
],
"driver_slugs": [
"d-cardiovascular"
],
"countries": [
"World"
],
"country_codes": [
"world"
],
"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1002/14651858.cd001800.pub5",
"source": "Cochrane Database of Systematic Reviews, 18 September 2026",
"paper_title": "Exercise-based cardiac rehabilitation for coronary heart disease",
"authors": "Dibben G, de Vries FB, Faulkner J, Oldridge N, Rees K, Stens NA et al.",
"doi": "10.1002/14651858.cd001800.pub5",
"type": "Peer-reviewed article",
"design": "Cochrane systematic review and meta-analysis of 107 randomised trials, 26,886 adults with coronary heart disease, searches to March 2026",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
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"reason": "",
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"superseded_by": "",
"attention": "1 citation (Crossref) · as of 2026-10-23",
"published_as": "",
"corrected": ""
},
{
"kind": "item",
"title": "AT2-stimulating antihypertensives were linked to less dementia in two US cohorts",
"excerpt": "In 1.6 million Medicare beneficiaries and 80,267 Vanderbilt patients aged 65 and over with hypertension, incident Alzheimer's disease and related dementias were less common among users of angiotensin II receptor-stimulating than receptor-inhibiting antihypertensives (6.7% against 8.2% in Medicare).",
"url": "https://www.coios.me/at2-stimulating-antihypertensives-were-linked-to-less/",
"published_at": "2026-09-20T00:06:37.000Z",
"updated_at": "2026-10-18T12:16:59.000Z",
"domain": "Health today",
"drivers": [
"Dementia"
],
"driver_slugs": [
"d-dementia"
],
"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "preprint",
"verdict": "confirms",
"source_url": "https://doi.org/10.64898/2026.09.11.26362859",
"source": "medRxiv, 17 September 2026",
"paper_title": "Antihypertensive Medication Class and Incident Alzheimer’s Disease and Related Dementias: External Replication Across Two Independent Healthcare Data Sources-the Vanderbilt EHR Synthetic Derivative and US Medicare Claims",
"authors": "Tiwari A, Chen R, Tan Y, Yan Y, Wen Z, Wei W et al.",
"doi": "10.64898/2026.09.11.26362859",
"type": "Preprint",
"design": "Retrospective new-user, active-comparator cohort with propensity-score matching in two independent US sources: Medicare claims 2015–2023 (n=1,596,034) and Vanderbilt EHR (n=80,267), ~7 years' follow-up",
"coverage": "",
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"access": "",
"change": "",
"series": "",
"vintages": "",
"size": "",
"reason": "",
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"attention": "",
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"corrected": ""
},
{
"kind": "item",
"title": "Australians in same-sex relationships had about a quarter higher all-cause mortality",
"excerpt": "Australian census records linked to death registrations show all-cause mortality a quarter higher among adults in same-sex than different-sex relationships, and external-cause mortality two to three times higher.",
"url": "https://www.coios.me/mortality-was-about-a-quarter-higher-for-australians-in/",
"published_at": "2026-09-20T00:06:23.000Z",
"updated_at": "2026-10-18T12:16:59.000Z",
"domain": "Data, models and systems",
"drivers": [
"What linked data reveals"
],
"driver_slugs": [
"d-linked-data"
],
"countries": [
"Australia"
],
"country_codes": [
"au"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.2105/ajph.2026.308712",
"source": "American journal of public health, 17 September 2026",
"paper_title": "All-Cause and External-Cause Mortality Disparities Among Australians in Same-Sex Relationships Before and After Marriage Equality: A Nationwide Cohort Study, 2011-2023",
"authors": "Saxby K",
"doi": "10.2105/ajph.2026.308712",
"type": "Peer-reviewed article",
"design": "Census-linked national cohort, 54,529 adults in same-sex vs 7,923,328 in different-sex relationships, Cox models with inverse probability weighting, 2011-2023",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
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"size": "",
"reason": "",
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"attention": "",
"published_as": "",
"corrected": ""
},
{
"kind": "item",
"title": "Most US adults starting a GLP-1 obesity drug stop within the year",
"excerpt": "Among 201,229 insured US adults with obesity and no diabetes starting a GLP-1 drug, 30.7% stayed on it for most of the following year, as did 20.3% of paediatric patients.",
"url": "https://www.coios.me/31-of-us-adults-starting-a-glp-1-drug-for-obesity-were/",
"published_at": "2026-09-20T00:06:10.000Z",
"updated_at": "2026-10-18T12:16:59.000Z",
"domain": "Behavioural science",
"drivers": [
"Adherence and persistence",
"Obesity, diabetes and GLP-1"
],
"driver_slugs": [
"d-adherence",
"d-obesity-diabetes"
],
"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1111/dom.71299",
"source": "Diabetes, Obesity and Metabolism, 17 September 2026",
"paper_title": "Real-World Adherence Trajectories of GLP-1 Receptor Agonists Among Adults and Paediatric Patients With Obesity",
"authors": "Huang W, Kotecha P, Kimmel SE, Segal R, Gonzalvo JD, Pecoski AM et al.",
"doi": "10.1111/dom.71299",
"type": "Peer-reviewed article",
"design": "Retrospective cohort of US commercial claims (MarketScan 2021-2023), 201,229 adults and 1,139 patients aged 10-17 with obesity and no diabetes, group-based trajectory modelling of 12-month proportion of days covered",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
"vintages": "",
"size": "",
"reason": "",
"supersedes": "",
"superseded_by": "",
"attention": "",
"published_as": "",
"corrected": ""
},
{
"kind": "item",
"title": "21-valent pneumococcal vaccine could prevent 1.5-1.7 times as many cases as 20-valent",
"excerpt": "National surveillance and a multicentre pneumonia study in Japan estimate the 21-valent pneumococcal vaccine could prevent 1.5-1.7 times as many cases as the 20-valent in adults aged 65 and over.",
"url": "https://www.coios.me/pcv21-would-prevent-1-5-1-7-times-as-many-pneumococcal/",
"published_at": "2026-09-18T23:18:02.000Z",
"updated_at": "2026-10-18T12:16:59.000Z",
"domain": "Data, models and systems",
"drivers": [
"Forecasts and their record"
],
"driver_slugs": [
"d-forecasting"
],
"countries": [
"Japan"
],
"country_codes": [
"jp"
],
"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.09.15.26363097",
"source": "medRxiv, 16 September 2026",
"paper_title": "Estimation of preventable pneumococcal disease burden by PCV20 or PCV21 under the national immunization program for adults aged 65 years in Japan",
"authors": "Tamura K, Chang B, Shimbashi R, Gotoh K, Tanabe Y, Kuronuma K et al.",
"doi": "10.64898/2026.09.15.26363097",
"type": "Preprint",
"design": "Burden estimation combining nationwide adult invasive pneumococcal disease surveillance and multicentre pneumococcal pneumonia data, Japan, serotypes 2023–2025, applied to reported vaccine efficacy",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
"vintages": "",
"size": "",
"reason": "",
"supersedes": "",
"superseded_by": "",
"attention": "",
"published_as": "",
"corrected": ""
},
{
"kind": "item",
"title": "Self-guided lifestyle app lowered LDL-cholesterol by 3.9% more than usual care",
"excerpt": "In a pragmatic online trial of 278 adults with LDL-cholesterol above target, a self-guided lifestyle app lowered LDL by 3.9% more than usual care at six months.",
"url": "https://www.coios.me/self-guided-lipid-app-cut-ldl-cholesterol-by-3-9-more-than/",
"published_at": "2026-09-18T23:17:39.000Z",
"updated_at": "2026-10-18T12:16:59.000Z",
"domain": "Tomorrow's world",
"drivers": [
"Innovation in treatment",
"Heart and stroke",
"Changing behaviour at scale"
],
"driver_slugs": [
"d-treatment-innovation",
"d-cardiovascular",
"d-behaviour-change"
],
"countries": [],
"country_codes": [],
"source_type": "preprint",
"verdict": "refines",
"source_url": "https://doi.org/10.64898/2026.09.15.26363103",
"source": "medRxiv, 16 September 2026",
"paper_title": "A self-guided digital health application for LDL-cholesterol reduction in adults with hypercholesterolaemia (The DIGICHOL randomised controlled trial)",
"authors": "Riepenhausen A, Ekerdt C, Meyer B, Jauch-Chara K",
"doi": "10.64898/2026.09.15.26363103",
"type": "Preprint",
"design": "Pragmatic online 1:1 randomised controlled trial, n = 278 adults with LDL above risk-adapted target, six-month follow-up",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
"vintages": "",
"size": "",
"reason": "",
"supersedes": "",
"superseded_by": "",
"attention": "",
"published_as": "",
"corrected": ""
},
{
"kind": "item",
"title": "Fine particulate matter shows no association with ovarian cancer across pooled cohorts",
"excerpt": "A systematic review of 145 studies of environmental chemical exposures and gynaecologic cancers found no pooled association between PM2.5 and ovarian cancer (HR 1.02 per 5 µg/m³, 95% CI 0.91–1.13) and only a marginal one for endometrial cancer (HR 1.02, 95% CI 0.99–1.05).",
"url": "https://www.coios.me/fine-particulate-matter-shows-no-association-with-ovarian/",
"published_at": "2026-09-18T23:16:47.000Z",
"updated_at": "2026-10-18T12:17:00.000Z",
"domain": "Health today",
"drivers": [
"Cancer",
"A changing climate"
],
"driver_slugs": [
"d-cancer",
"d-climate"
],
"countries": [
"World"
],
"country_codes": [
"world"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1016/j.envres.2026.125661",
"source": "Environmental Research, 16 September 2026",
"paper_title": "Epidemiologic research on environmental chemical exposures and ovarian and endometrial cancers: a systematic review",
"authors": "Ammons S, Post LM, Pruitt C, Sisson P, Shields TC, Applebaum KM et al.",
"doi": "10.1016/j.envres.2026.125661",
"type": "Peer-reviewed article",
"design": "Systematic review of 145 epidemiologic studies with meta-analysis of 7 PM2.5 studies",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
"vintages": "",
"size": "",
"reason": "",
"supersedes": "",
"superseded_by": "",
"attention": "",
"published_as": "",
"corrected": ""
},
{
"kind": "item",
"title": "Education and wealth are associated with lower biological age in 12 European countries",
"excerpt": "In 10,043 to 14,015 SHARE adults aged 50-75, every measure of socioeconomic advantage was associated with a lower estimated biological age, though the gap differed between the 12 countries.",
"url": "https://www.coios.me/socioeconomic-advantage-tracks-slower-biological-ageing/",
"published_at": "2026-09-18T23:16:34.000Z",
"updated_at": "2026-10-18T12:17:00.000Z",
"domain": "Data, models and systems",
"drivers": [
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],
"driver_slugs": [
"d-health-systems"
],
"countries": [
"European Union"
],
"country_codes": [
"eu"
],
"source_type": "preprint",
"verdict": "confirms",
"source_url": "https://doi.org/10.64898/2026.09.11.26361838",
"source": "medRxiv, 16 September 2026",
"paper_title": "Multidimensional socioeconomic gradients in biological age acceleration across 12 countries in the SHARE study",
"authors": "Guo H",
"doi": "10.64898/2026.09.11.26361838",
"type": "Preprint",
"design": "Cross-national cohort analysis of SHARE Wave 6 biomarkers (10,043-14,015 adults aged 50-75, 12 countries, 2015, followed to Wave 9)",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
"vintages": "",
"size": "",
"reason": "",
"supersedes": "",
"superseded_by": "",
"attention": "",
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"corrected": ""
},
{
"kind": "item",
"title": "China's clean-heating pilots cut winter PM2.5 most on the worst pollution days",
"excerpt": "Across 88 clean-heating pilot cities in northern China, heating-season PM2.5 fell by 3.01 micrograms per cubic metre on average, and by 5.96 on the most polluted days.",
"url": "https://www.coios.me/china-s-clean-heating-pilots-cut-heating-season-pm2-5-most/",
"published_at": "2026-09-18T23:15:20.000Z",
"updated_at": "2026-10-18T12:17:00.000Z",
"domain": "Tomorrow's world",
"drivers": [
"A changing climate"
],
"driver_slugs": [
"d-climate"
],
"countries": [
"China"
],
"country_codes": [
"cn"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1016/j.jenvman.2026.130960",
"source": "Journal of Environmental Management, 16 September 2026",
"paper_title": "Distribution-sensitive assessment of air-quality and health benefits from clean-heating pilots in northern China",
"authors": "Bao JL, Cong RG",
"doi": "10.1016/j.jenvman.2026.130960",
"type": "Peer-reviewed article",
"design": "Quasi-experimental evaluation of 88 clean-heating pilot cities in northern China, 2013-2023, using weather-normalised daily PM2.5 and augmented synthetic control, with a modelled short-term mortality impact assessment",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
"vintages": "",
"size": "",
"reason": "",
"supersedes": "",
"superseded_by": "",
"attention": "",
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"corrected": ""
},
{
"kind": "item",
"title": "Model using intake records predicted six-month deaths in Taiwanese care homes",
"excerpt": "A model built from routine intake assessments in 636 Taiwanese care homes predicted death within 180 days of admission, with an AUROC of 0.90 in a separate 2024 cohort.",
"url": "https://www.coios.me/machine-learning-predicted-six-month-mortality-after/",
"published_at": "2026-09-18T23:15:07.000Z",
"updated_at": "2026-10-18T12:17:00.000Z",
"domain": "Data, models and systems",
"drivers": [
"AI in medicine",
"Frailty and multimorbidity"
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"driver_slugs": [
"d-ai-medicine",
"d-frailty-multimorbidity"
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"countries": [
"Taiwan"
],
"country_codes": [
"tw"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.2196/94567",
"source": "JMIR Aging, 16 September 2026",
"paper_title": "Development and Temporal External Validation of a Parsimonious, Interpretable Machine Learning Model for Predicting 6-Month Mortality in Long-Term Care Facilities: A Retrospective Cohort Study",
"authors": "Tsai YC, Wu YL, Yu YC, Chen YW, Chen YW, Yang YC et al.",
"doi": "10.2196/94567",
"type": "Peer-reviewed article",
"design": "Retrospective cohort using a nationwide private LTCF registry (636 facilities); development n=23,901 (2020-2023), temporal external validation n=6,216 (2024)",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
"vintages": "",
"size": "",
"reason": "",
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"attention": "",
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"corrected": ""
},
{
"kind": "item",
"title": "Weaker social ties before surgery are linked to early death and non-home discharge",
"excerpt": "Patients with weaker social connection before surgery had 1.50 times the odds of early postoperative death and 1.95 times the odds of being discharged somewhere other than home.",
"url": "https://www.coios.me/weaker-social-ties-before-surgery-track-early-death-and-non/",
"published_at": "2026-09-18T23:14:23.000Z",
"updated_at": "2026-10-18T12:17:00.000Z",
"domain": "Behavioural science",
"drivers": [
"Social connection"
],
"driver_slugs": [
"d-social-connection"
],
"countries": [
"World"
],
"country_codes": [
"world"
],
"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.09.15.26363083",
"source": "medRxiv, 16 September 2026",
"paper_title": "Preoperative Social Connection and Postoperative Outcomes in Adults Undergoing Surgery: A Systematic Review and Meta-analysis",
"authors": "Yin C, Wang Y, Jiang L, Huang X, Zhang Z, Jing Z",
"doi": "10.64898/2026.09.15.26363083",
"type": "Preprint",
"design": "Systematic review and meta-analysis of 445 studies, 72 poolable, up to ~298,000 patients per outcome; searches to July 2026",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
"vintages": "",
"size": "",
"reason": "",
"supersedes": "",
"superseded_by": "",
"attention": "",
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"corrected": ""
},
{
"kind": "item",
"title": "Adults with diabetes lost more muscle after starting a GLP-1 drug",
"excerpt": "In the German National Cohort, adults with diabetes who started a GLP-1 drug lost 2.75 percentage points more skeletal muscle volume than matched adults who did not.",
"url": "https://www.coios.me/glp-1-initiators-lost-2-75-points-more-skeletal-muscle-on/",
"published_at": "2026-09-18T23:14:08.000Z",
"updated_at": "2026-10-18T12:17:00.000Z",
"domain": "Health today",
"drivers": [
"Obesity, diabetes and GLP-1"
],
"driver_slugs": [
"d-obesity-diabetes"
],
"countries": [
"Germany"
],
"country_codes": [
"de"
],
"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.09.15.26363157",
"source": "medRxiv, 17 September 2026",
"paper_title": "GLP-1 Receptor Agonist Initiation Is Associated With Excess Skeletal Muscle Loss in Adults With Diabetes: A Prospective Population-Based MRI Study",
"authors": "Stambollxhiu E, Luebberstedt J, Kumpf M, Willich SN, Keil T, Pischon T et al.",
"doi": "10.64898/2026.09.15.26363157",
"type": "Preprint",
"design": "Matched prospective cohort within the German National Cohort, 58 GLP-1 initiators vs 130 unexposed adults with diabetes, repeat whole-body MRI 4.6 years apart",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
"series": "",
"vintages": "",
"size": "",
"reason": "",
"supersedes": "",
"superseded_by": "",
"attention": "",
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},
{
"kind": "item",
"title": "New Zealand had few excess deaths through the pandemic and its aftermath",
"excerpt": "A model fitted to 22 years of monthly death counts estimates that New Zealand had few excess deaths during the pandemic, and was back to pre-pandemic mortality by 2025.",
"url": "https://www.coios.me/a-bayesian-model-extends-excess-death-estimation-to-six/",
"published_at": "2026-09-18T23:13:56.000Z",
"updated_at": "2026-10-18T12:17:01.000Z",
"domain": "Data, models and systems",
"drivers": [
"Forecasts and their record"
],
"driver_slugs": [
"d-forecasting"
],
"countries": [
"New Zealand"
],
"country_codes": [
"nz"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://www.demographic-research.org/articles/volume/55/17#ref=rss",
"source": "Demographic Research, 17 September 2026",
"paper_title": "",
"authors": "",
"doi": "",
"type": "Peer-reviewed article",
"design": "Bayesian hierarchical forecasting model fitted to 22 years of monthly deaths by age and sex, applied to New Zealand, February 2020 to December 2025",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
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"vintages": "",
"size": "",
"reason": "",
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},
{
"kind": "item",
"title": "The largest treatment gaps are not where cardiovascular risk could fall most",
"excerpt": "The populations with the largest treatment gaps were not those where treating currently untreated people would achieve the greatest absolute reduction in cardiovascular risk.",
"url": "https://www.coios.me/biggest-cardiometabolic-treatment-gaps-are-not-where-most/",
"published_at": "2026-09-18T23:13:36.000Z",
"updated_at": "2026-10-18T12:17:01.000Z",
"domain": "Health today",
"drivers": [
"Heart and stroke",
"Health systems and access"
],
"driver_slugs": [
"d-cardiovascular",
"d-health-systems"
],
"countries": [
"World"
],
"country_codes": [
"world"
],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(26)00244-5/fulltext?rss=yes",
"source": "The Lancet Global Health, 17 September 2026",
"paper_title": "",
"authors": "",
"doi": "",
"type": "Peer-reviewed article",
"design": "Pooled analysis of individual participant data from nationally representative surveys in 76 countries, stratified by wealth, region and sex",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
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"vintages": "",
"size": "",
"reason": "",
"supersedes": "",
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"corrected": ""
},
{
"kind": "item",
"title": "Landscape fire smoke accounted for 1.9% of deaths and $994.5 billion in losses",
"excerpt": "Across 1366 communities in ten countries and territories over 2000-19, smoke from landscape fires was estimated to account for 906,869 deaths and $994.5 billion in mortality-related economic losses.",
"url": "https://www.coios.me/wildfire-smoke-accounted-for-1-9-of-deaths-across-ten/",
"published_at": "2026-09-18T23:13:24.000Z",
"updated_at": "2026-10-18T12:17:01.000Z",
"domain": "Tomorrow's world",
"drivers": [
"A changing climate"
],
"driver_slugs": [
"d-climate"
],
"countries": [
"World"
],
"country_codes": [
"world"
],
"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1016/j.lanplh.2026.101506",
"source": "The Lancet Planetary Health, 16 September 2026",
"paper_title": "Premature mortality and economic losses attributable to landscape fire-related PM2·5 in ten countries and territories: a causal analysis",
"authors": "Ju K, Xu R, Huang W, Yang Z, Ye T, Yu W et al.",
"doi": "10.1016/j.lanplh.2026.101506",
"type": "Peer-reviewed article",
"design": "Multi-country time-series with instrumental-variable estimation, 1366 communities in ten countries and territories, 47.8 million deaths, 2000-19",
"coverage": "",
"granularity": "",
"latency": "",
"access": "",
"change": "",
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"vintages": "",
"size": "",
"reason": "",
"supersedes": "",
"superseded_by": "",
"attention": "",
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"corrected": ""
},
{
"kind": "item",
"title": "Residential greenspace linked to lower respiratory deaths from air pollution",
"excerpt": "A review of 14 cohort studies, mostly European, found residential greenspace associated with lower air-pollution-related respiratory mortality, through cleaner local air rather than reduced personal susceptibility to pollution.",
"url": "https://www.coios.me/greenspace-tracks-lower-pollution-related-respiratory/",
"published_at": "2026-09-17T09:25:44.000Z",
"updated_at": "2026-10-18T12:17:01.000Z",
"domain": "Tomorrow's world",
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"A changing climate"
],
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"d-climate"
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"World"
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"country_codes": [
"world"
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"source_type": "peer-reviewed",
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"source_url": "https://doi.org/10.1177/14034948261481328",
"source": "Scandinavian Journal of Public Health, 15 September 2026",
"paper_title": "Greenspace, air pollution and respiratory health outcomes: a systematic review of cohort studies",
"authors": "Vance MS, Lane T, Ye T",
"doi": "10.1177/14034948261481328",
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{
"kind": "item",
"title": "Diabetes was more common in older US influenza deaths than in COVID-19 deaths",
"excerpt": "Among US inpatients aged over 65 who died, 46.6% of those dying of COVID-19 had diabetes, as compared to 63.1% of those dying of influenza.",
"url": "https://www.coios.me/diabetes-was-commoner-in-older-us-flu-inpatient-deaths-than/",
"published_at": "2026-09-17T09:25:33.000Z",
"updated_at": "2026-10-18T12:17:01.000Z",
"domain": "Health today",
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"Obesity, diabetes and GLP-1",
"Revisions and new sources"
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"d-obesity-diabetes",
"d-data-sources"
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"United States"
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"us"
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1186/s40842-026-00325-0",
"source": "Cardiovascular Diabetology – Endocrinology Reports, 15 September 2026",
"paper_title": "Among individuals who die of COVID-19, is the percentage who had diabetes actually higher than in those dying of other viral infections?",
"authors": "Reddy NV, Pate V, Stürmer T, Wong R, Harper J, Reusch JE et al.",
"doi": "10.1186/s40842-026-00325-0",
"type": "Peer-reviewed article",
"design": "Cross-sectional comparison of two US databases (N3C EHR enclave for COVID-19, Medicare claims for influenza), inpatient decedents aged over 65",
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{
"kind": "item",
"title": "Pancreatic cancer risk on GLP-1 drugs depends on the diabetes drug compared",
"excerpt": "Pancreatic cancer was less common in GLP-1 starters than in starters of four other diabetes classes, while against insulin the paper reports a lower hazard but a higher absolute risk.",
"url": "https://www.coios.me/glp-1-pancreatic-cancer-hazard-shifts-with-the-comparator/",
"published_at": "2026-09-17T09:25:20.000Z",
"updated_at": "2026-10-18T12:17:02.000Z",
"domain": "Health today",
"drivers": [
"Cancer",
"Obesity, diabetes and GLP-1"
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"driver_slugs": [
"d-cancer",
"d-obesity-diabetes"
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"countries": [
"United States"
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"us"
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1007/s12029-026-01523-w",
"source": "Journal of Gastrointestinal Cancer, 16 September 2026",
"paper_title": "Long-Term Association Between GLP-1 Receptor Agonist Use and Incident Pancreatic Cancer: A Propensity Score-Matched Retrospective Cohort Study Using the TriNetX Network",
"authors": "Kazi MAI, Khan J, Mufarrih SM, Siddiqui M, Ansari HUH, Ahmed M et al.",
"doi": "10.1007/s12029-026-01523-w",
"type": "Peer-reviewed article",
"design": "Retrospective new-user cohort in the TriNetX federated EHR network, adults with type 2 diabetes, six separate 1:1 propensity-score-matched comparisons on 39 covariates, outcome incident pancreatic cancer 365-7,300 days after index",
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{
"kind": "item",
"title": "Colorectal screening from 45 still misses cancers diagnosed before that age",
"excerpt": "A review of 45 studies found detection of colorectal neoplasia rises with age under 50, but a considerable share of cases arise before 45 and outside screening eligibility.",
"url": "https://www.coios.me/lowering-colorectal-screening-to-45-still-misses-much-early/",
"published_at": "2026-09-17T09:24:59.000Z",
"updated_at": "2026-10-18T12:17:02.000Z",
"domain": "Health today",
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"Cancer"
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"d-cancer"
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"World"
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"country_codes": [
"world"
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1016/j.canep.2026.103231",
"source": "Cancer Epidemiology, 15 September 2026",
"paper_title": "Screening effectiveness and diagnostic gaps in early-onset colorectal cancer: A systematic review",
"authors": "Ataca E, Çınaroğlu D, Tarhan MO, Ellidokuz H",
"doi": "10.1016/j.canep.2026.103231",
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"design": "Systematic review, narrative synthesis (SWiM) of 45 studies published 2000-2026, adults under 50",
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{
"kind": "item",
"title": "Cardiogenic shock deaths fall as hospital cardiac capability rises in US admissions",
"excerpt": "Across an estimated 1.18 million US admissions for cardiogenic shock, crude in-hospital mortality fell from 64.4% at hospitals without percutaneous coronary intervention to 36.5% at heart transplant centres.",
"url": "https://www.coios.me/cardiogenic-shock-deaths-fall-stepwise-with-hospital/",
"published_at": "2026-09-17T09:24:25.000Z",
"updated_at": "2026-10-18T12:17:02.000Z",
"domain": "Health today",
"drivers": [
"Heart and stroke"
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"d-cardiovascular"
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"countries": [
"United States"
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"us"
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1161/circheartfailure.126.014546",
"source": "Circulation: Heart Failure, 15 September 2026",
"paper_title": "Association Between Hospital Tiers and Cardiogenic Shock Mortality: Mitigating the Transfer Penalty Through a Regionalized Hub-and-Spoke Model",
"authors": "Sethi A, Hiltner E, Awasthi A, Panebianco C, LaPlaca T, Rizzuto N et al.",
"doi": "10.1161/circheartfailure.126.014546",
"type": "Peer-reviewed article",
"design": "Retrospective analysis of US National Inpatient Sample, 2016-2022, ~1,177,180 cardiogenic shock hospitalisations, hospitals in five capability tiers, structural equation model with latent severity construct",
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{
"kind": "item",
"title": "GLP-1 drugs cut weight by 6.7 kg in patients taking antipsychotics",
"excerpt": "A meta-analysis of eight randomised trials in 664 patients taking antipsychotics found that GLP-1 receptor agonists reduced body weight by 6.74 kg, alongside more nausea, vomiting and constipation.",
"url": "https://www.coios.me/glp-1-drugs-cut-weight-by-6-7-kg-in-antipsychotic-treated/",
"published_at": "2026-09-17T09:24:15.000Z",
"updated_at": "2026-10-18T12:17:02.000Z",
"domain": "Health today",
"drivers": [
"Obesity, diabetes and GLP-1"
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"driver_slugs": [
"d-obesity-diabetes"
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"World"
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"country_codes": [
"world"
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1177/02698811261478625",
"source": "Journal of Psychopharmacology, 16 September 2026",
"paper_title": "Adjunctive GLP-1 receptor agonists for cardiometabolic risk in antipsychotic-treated patients: A GRADE-assessed meta-analysis of randomized trials",
"authors": "Moubarak ES, Elgendy MS, Elkoumi O, Ibrahim AA, Manasrah A, Ahmad J et al.",
"doi": "10.1177/02698811261478625",
"type": "Peer-reviewed article",
"design": "Systematic review and meta-analysis of 8 randomised trials, 664 patients, searched to May 2026",
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"kind": "item",
"title": "Second primary lung cancers in Sweden have risen steadily since 1980",
"excerpt": "The Swedish national cancer registry identified 853 second primary lung cancers from 1961 to 2021, arising at 3.59 times the rate at which first lung cancers arise in the population.",
"url": "https://www.coios.me/second-primary-lung-cancers-in-sweden-have-risen-steadily/",
"published_at": "2026-09-17T09:24:07.000Z",
"updated_at": "2026-10-18T12:17:02.000Z",
"domain": "Health today",
"drivers": [
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"d-cancer"
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"Sweden"
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"se"
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1136/thorax-2025-223426",
"source": "Thorax, 15 September 2026",
"paper_title": "Increase in second primary lung cancers in a nation-wide cohort study from Sweden",
"authors": "Zitricky F, Sundquist K, Sundquist J, Försti A, Hemminki A, Kaaks R et al.",
"doi": "10.1136/thorax-2025-223426",
"type": "Peer-reviewed article",
"design": "National cancer registry cohort, Sweden 1961-2021, 853 second primary lung cancers",
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"attention": "1 citation (Crossref) · as of 2026-10-16",
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},
{
"kind": "item",
"title": "Scotland's lung screening pilot drew a 23.8% response to its invitations",
"excerpt": "Inviting 2801 people with a smoking history recorded in Scottish primary care records to a lung health check produced a response rate of 23.8%, lower in more deprived areas.",
"url": "https://www.coios.me/lung-screening-invitations-in-scotland-drew-a-24-response/",
"published_at": "2026-09-17T09:23:47.000Z",
"updated_at": "2026-10-18T12:17:02.000Z",
"domain": "Health today",
"drivers": [
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"countries": [
"United Kingdom"
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"country_codes": [
"gb"
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1136/bmjopen-2026-120569",
"source": "BMJ Open, 15 September 2026",
"paper_title": "Pilot feasibility study to deliver low-dose CT lung cancer screening in Scotland: descriptive findings from the LungScot study",
"authors": "Cavers D, Akram AR, Sage EK, Maclay JD, Cowell GW, Mitchell J et al.",
"doi": "10.1136/bmjopen-2026-120569",
"type": "Peer-reviewed article",
"design": "Prospective multicentre pilot feasibility study, 2801 invited, 436 scanned, four Scottish health boards",
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},
{
"kind": "item",
"title": "Infant RSV hospitalisations fell two thirds in Quebec's first nirsevimab season",
"excerpt": "In Quebec's first season of offering nirsevimab to all infants, hospitalisations with a positive RSV test in those aged 0-5 months fell by 66%, and bronchiolitis emergency visits by 35%.",
"url": "https://www.coios.me/qu-bec-s-first-universal-nirsevimab-season-cut-infant-rsv/",
"published_at": "2026-09-17T09:23:18.000Z",
"updated_at": "2026-10-18T12:17:03.000Z",
"domain": "Behavioural science",
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"countries": [
"Canada"
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"country_codes": [
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"source_type": "peer-reviewed",
"verdict": "confirms",
"source_url": "https://doi.org/10.1097/ede.0000000000002050",
"source": "Epidemiology, 15 September 2026",
"paper_title": "Impact of the first nirsevimab immunization campaign on infant RSV-related emergency department visits and hospitalizations in Québec, Canada",
"authors": "Bemmo A, Fortin É, Fortin P, Doggui R, Guay CA, Amini R et al.",
"doi": "10.1097/ede.0000000000002050",
"type": "Peer-reviewed article",
"design": "Population-level quasi-experimental evaluation (difference-in-differences and counterfactual) using surveillance and administrative data, all Québec children under 18, 2024-25 RSV season versus prior seasons",
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{
"kind": "item",
"title": "GLP-1 drugs did not reduce new sleep apnoea diagnoses in UK diabetes patients",
"excerpt": "Among UK adults with type 2 diabetes and obesity, those starting a GLP-1 drug rather than a weight-neutral DPP-4 inhibitor had no fewer new sleep apnoea diagnoses (hazard ratio 1.07).",
"url": "https://www.coios.me/glp-1-drugs-did-not-lower-new-sleep-apnoea-diagnoses-in-uk/",
"published_at": "2026-09-17T09:23:08.000Z",
"updated_at": "2026-10-18T12:17:03.000Z",
"domain": "Health today",
"drivers": [
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"countries": [
"United Kingdom"
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"country_codes": [
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"source_type": "peer-reviewed",
"verdict": "refines",
"source_url": "https://doi.org/10.1093/ajrccm/aamag474",
"source": "American Journal of Respiratory and Critical Care Medicine, 15 September 2026",
"paper_title": "Effectiveness of GLP-1 receptor agonists to prevent obstructive sleep apnea in patients with type 2 diabetes: active comparator, new user cohort study",
"authors": "Khouri C, Dell'Aniello S, Jambon Barbara C, Azoulay L, Suissa S, Pepin JL",
"doi": "10.1093/ajrccm/aamag474",
"type": "Peer-reviewed article",
"design": "Active-comparator, new-user cohort study in UK CPRD, 2007-2023; 47,315 GLP-1 RA vs 159,066 DPP-4 inhibitor initiators with type 2 diabetes and BMI =30, up to 3 years' follow-up",
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{
"kind": "item",
"title": "Oral KRAS G12D inhibitor GFH375 shrank tumours in a third of pancreatic cancers",
"excerpt": "In 74 heavily pretreated patients with KRAS G12D-mutant advanced solid tumours, the oral inhibitor GFH375 produced confirmed responses in 35.1% of pancreatic cancers and 35.7% of lung cancers.",
"url": "https://www.coios.me/an-oral-kras-g12d-inhibitor-shrank-tumours-in-a-third-of/",
"published_at": "2026-09-17T09:22:55.000Z",
"updated_at": "2026-10-18T12:17:03.000Z",
"domain": "Health today",
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"countries": [
"China"
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"cn"
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1038/s41591-026-04559-4",
"source": "Nature Medicine, 15 September 2026",
"paper_title": "Oral KRAS G12D inhibitor GFH375 for previously treated advanced solid tumors with KRASG12D mutations: a phase 1 trial",
"authors": "Ai X, Song Z, Wu L, Zhou A, Cheng D, Zong H et al.",
"doi": "10.1038/s41591-026-04559-4",
"type": "Peer-reviewed article",
"design": "Phase 1 dose-escalation and expansion trial, 74 heavily pretreated patients with KRAS G12D-mutant advanced solid tumours (43 pancreatic, 16 lung, 10 colorectal)",
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{
"kind": "item",
"title": "Most dementia trial participants had more than one brain pathology at autopsy",
"excerpt": "Among 67 autopsied participants in dementia trials at a Kentucky research centre, only 10 to 29% had solely the pathology that the trial's intervention was designed to target.",
"url": "https://www.coios.me/most-dementia-trial-participants-had-mixed-brain-pathology/",
"published_at": "2026-09-17T09:22:47.000Z",
"updated_at": "2026-10-18T12:17:03.000Z",
"domain": "Health today",
"drivers": [
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1016/j.tjpad.2026.100669",
"source": "The Journal of Prevention of Alzheimer's Disease, 15 September 2026",
"paper_title": "Autopsy findings in Alzheimer's disease clinical trial participants demonstrate a high frequency of off-target coexisting pathologic features",
"authors": "Coskun EP, Barber J, Bojarski L, McLouth CJ, Abner EL, Van Eldik LJ et al.",
"doi": "10.1016/j.tjpad.2026.100669",
"type": "Peer-reviewed article",
"design": "Retrospective autopsy series, 614 autopsied community cohort members, 67 former dementia trial participants, deaths 2005–2024, University of Kentucky ADRC",
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{
"kind": "item",
"title": "Wildfire smoke is linked to shorter survival in older US lung cancer patients",
"excerpt": "A SEER-Medicare cohort of 414,016 patients aged 65 or older with lung cancer found shorter overall survival with higher long-term exposure to wildfire-related fine particles.",
"url": "https://www.coios.me/wildfire-pm2-5-exposure-is-linked-to-shorter-survival-in/",
"published_at": "2026-09-17T09:22:33.000Z",
"updated_at": "2026-10-18T12:17:03.000Z",
"domain": "Health today",
"drivers": [
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"A changing climate"
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"d-climate"
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"United States"
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"country_codes": [
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"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://doi.org/10.1016/s1470-2045(26)00295-0",
"source": "The Lancet Oncology, 15 September 2026",
"paper_title": "Long-term exposure to wildfire-related PM2·5 and overall survival of older patients with lung cancer: a retrospective, registry-based cohort study",
"authors": "Zhang M, Wisnivesky JP, Qiu M, Danesh Yazdi M, Yin K, Wright RJ et al.",
"doi": "10.1016/s1470-2045(26)00295-0",
"type": "Peer-reviewed article",
"design": "Retrospective registry cohort, SEER-Medicare, 414,016 patients aged 65+ with lung cancer, 2008-2019, 1.21m person-years, time-varying Cox models of 3-year moving average exposure",
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},
{
"kind": "item",
"title": "Blood test used with the standard marker CA19-9 detected early-stage pancreatic cancer",
"excerpt": "A prospective study of 1,785 people across four countries reports that an exosome-based blood test, used with the standard marker CA19-9, detected early-stage pancreatic cancer with high sensitivity.",
"url": "https://www.coios.me/an-exosome-biomarker-with-ca19-9-detected-early-stage/",
"published_at": "2026-09-17T09:22:24.000Z",
"updated_at": "2026-10-18T12:17:04.000Z",
"domain": "Health today",
"drivers": [
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"driver_slugs": [
"d-cancer"
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"countries": [],
"country_codes": [],
"source_type": "peer-reviewed",
"verdict": "new",
"source_url": "https://www.nature.com/articles/s41591-026-04625-x",
"source": "Nature Medicine, 16 September 2026",
"paper_title": "",
"authors": "",
"doi": "",
"type": "Peer-reviewed article",
"design": "Prospective multi-centre biomarker validation study, 1,785 individuals across four countries",
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{
"kind": "item",
"title": "Language model identifies neurodegenerative disease from autopsy text in 75% of cases",
"excerpt": "In 5,613 Mayo Clinic autopsies, a language model scoring gross brain descriptions gave the correct diagnosis in 75% of held-out cases, but rarely identified combined Alzheimer and Lewy body disease.",
"url": "https://www.coios.me/llm-extracted-autopsy-brain-features-classify/",
"published_at": "2026-09-16T21:08:10.000Z",
"updated_at": "2026-10-18T12:17:04.000Z",
"domain": "Data, models and systems",
"drivers": [
"AI in medicine"
],
"driver_slugs": [
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"countries": [
"United States"
],
"country_codes": [
"us"
],
"source_type": "preprint",
"verdict": "new",
"source_url": "https://doi.org/10.64898/2026.09.12.26362866",
"source": "medRxiv, 14 September 2026",
"paper_title": "Diagnostic Value of Large Language Model-Extracted Gross Brain Findings in Neurodegenerative Diseases",
"authors": "Ono D, Dickson DW, Koga S",
"doi": "10.64898/2026.09.12.26362866",
"type": "Preprint",
"design": "Retrospective classification study of 5,613 Mayo Clinic Brain Bank autopsies, 1998–2023, held-out test set of 562",
"coverage": "",
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"title": "A locally run AI system removed 99.8% of identifiers planted in patient records",
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"source": "medRxiv, 14 September 2026",
"paper_title": "A locally deployable agentic framework for clinical data deidentification",
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"title": "Known dementia risk factors explain only part of exceptional cognition in older age",
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"source": "medRxiv, 14 September 2026",
"paper_title": "Cognition in Whitehall II ’SuperAgers’: An Analysis of Dementia Risk Factors",
"authors": "Watson P, Ebrahimi O, Gallacher J, Bauermeister S",
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"title": "Socioeconomic circumstances track the gap between loneliness and contact in older adults",
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"url": "https://www.coios.me/deprivation-and-renting-track-loneliness-in-excess-of/",
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"source": "The journals of gerontology. Series B, Psychological sciences and social sciences, 15 September 2026",
"paper_title": "Socioeconomic correlates of social asymmetry in English older adults: Findings from a population-based cohort study",
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"source": "medRxiv, 14 September 2026",
"paper_title": "Impact of HPV vaccination in Spain: Reductions in vaccine-type genotypes, cytological abnormalities, and the influence of epidemiological factors",
"authors": "García Señán AI, Lamo EA, Expósito AD, Martín MA, Comba Miranda JW, Valle Peña Dd et al.",
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"title": "Power to Quit campaign coincided with more quit attempts but no change in success",
"excerpt": "A pre/post evaluation of England's Power to Quit mass media campaign found quit attempts rose from 48.4% to 52.3% and use of digital support from 16.0% to 18.4%, both with confidence intervals spanning no effect, and no clear change in quit success.",
"url": "https://www.coios.me/power-to-quit-campaign-coincided-with-more-quit-attempts/",
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"source_url": "https://doi.org/10.64898/2026.09.14.26362985",
"source": "medRxiv, 15 September 2026",
"paper_title": "Are population-wide mass media campaigns still relevant in an era of low smoking prevalence? Insights from the Power to Quit campaign in England",
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"doi": "10.64898/2026.09.14.26362985",
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"title": "PCV20 was 20% effective against pneumococcal pneumonia admissions at ages 65 and over",
"excerpt": "Among 34,009 pneumonia hospitalisations in the US Veterans Affairs system, PCV20 was associated with 20.4% lower odds of culture-confirmed pneumococcal pneumonia at ages 65 and over.",
"url": "https://www.coios.me/pcv20-lowered-pneumococcal-pneumonia-admissions-by-a-fifth/",
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"source_url": "https://doi.org/10.64898/2026.09.13.26362937",
"source": "medRxiv, 14 September 2026",
"paper_title": "Effectiveness of 20-valent pneumococcal conjugate vaccine against pneumococcal pneumonia hospitalizations among U.S. adults: Test-Negative Design",
"authors": "Ologunowa AJ, Kogut S, Vrishali VL, Cohen S, Caffrey AR",
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"title": "Kidney disease stage tracks in-hospital deaths in STEMI shock on circulatory support",
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"url": "https://www.coios.me/advanced-ckd-tracks-higher-in-hospital-death-in-stemi-shock/",
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"source_url": "https://doi.org/10.1002/ccd.70881",
"source": "Catheterization and Cardiovascular Interventions, 13 September 2026",
"paper_title": "Impact of Chronic Kidney Disease Severity on Outcomes in STEMI-Associated Cardiogenic Shock Requiring Mechanical Circulatory Support",
"authors": "Rao A, Aafreen A, Nawaz S, Gopireddy NSR, Kolade V, Rao S et al.",
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"kind": "item",
"title": "No study has yet followed snus or e-cigarette users through chemotherapy",
"excerpt": "A review to June 2026 found no study of how snus or e-cigarettes affect response to chemotherapy, and the one laboratory signal of drug resistance did not replicate.",
"url": "https://www.coios.me/no-epidemiological-evidence-yet-links-e-cigarettes-or-snus/",
"published_at": "2026-09-15T21:44:20.000Z",
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"source": "Toxicology Mechanisms and Methods, 14 September 2026",
"paper_title": "Alternative tobacco and nicotine products during anticancer therapy: a systematic review of mechanistic toxicology evidence, treatment-resistance signals, and potential hazards",
"authors": "Kopa-Stojak PN, Pawliczak R",
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"title": "Modelled estimates put 10.6m new cancers at 65+ in 2022, rising 75% by 2036",
"excerpt": "A secondary analysis of GLOBOCAN 2022 and GBD 2021 estimates reports 10.6 million new cancer cases and 6.0 million cancer deaths among adults aged 65 and over in 2022, with the modelled case count projected to rise 75.5% by 2036 as populations age.",
"url": "https://www.coios.me/modelled-estimates-put-10-6m-new-cancers-at-65-in-2022/",
"published_at": "2026-09-15T21:43:49.000Z",
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"source_url": "https://doi.org/10.1016/j.jgo.2026.103413",
"source": "Journal of Geriatric Oncology, 13 September 2026",
"paper_title": "Global trends and disparities in cancer burden among older adults: From aging to oncology",
"authors": "Xiao W, Guan T, Liu S, Liu H, Zheng Y, Zhang Z et al.",
"doi": "10.1016/j.jgo.2026.103413",
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"kind": "item",
"title": "Asian Pacific Islanders had worse in-hospital outcomes after heart attack in the US",
"excerpt": "A propensity-matched analysis of US hospital admissions for heart attack from 2003 to 2022 found higher in-hospital mortality among Asian Pacific Islander patients than among other patients.",
"url": "https://www.coios.me/asian-pacific-islanders-had-higher-in-hospital-death-after/",
"published_at": "2026-09-15T21:43:33.000Z",
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"source": "Baylor University Medical Center Proceedings, 14 September 2026",
"paper_title": "In-hospital outcomes of acute myocardial infarction in Asian Pacific Islanders in the United States over the past two decades: a propensity score-matched analysis",
"authors": "Randhawa M, Yu D, Rai A, Mansoor T, Brubaker A, Paul A et al.",
"doi": "10.1080/08998280.2026.2717838",
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"kind": "item",
"title": "Pharmacies gave 42% of first COVID-19 vaccine doses to North Carolina children",
"excerpt": "Across 1.75 million North Carolina children aged 3-17, pharmacies gave 42% of first COVID-19 doses, and much the same share in rural, suburban and urban areas.",
"url": "https://www.coios.me/pharmacies-gave-42-of-first-covid-vaccine-doses-to-north/",
"published_at": "2026-09-15T21:43:07.000Z",
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"source_url": "https://doi.org/10.1016/j.vaccine.2026.129125",
"source": "Vaccine, 13 September 2026",
"paper_title": "Evaluating access to COVID-19 vaccines for children and adolescents in North Carolina through community pharmacies, 2021-2023",
"authors": "Blanchard C, Myers J, McNabb AL, Lee YA, Patel Y, Yemeke T et al.",
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"kind": "item",
"title": "Adults with obesity and asthma on GLP-1 drugs had fewer recorded exacerbations",
"excerpt": "In 2,423 matched pairs of adults with obesity and asthma, one-year recorded asthma exacerbation was 1.7% on GLP-1 therapy as compared to 4.0% on other weight-management drugs.",
"url": "https://www.coios.me/glp-1-users-with-obesity-and-asthma-recorded-fewer/",
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"source_url": "https://doi.org/10.1080/17476348.2026.2730537",
"source": "Expert Review of Respiratory Medicine, 13 September 2026",
"paper_title": "Association of GLP-1-based therapy with asthma-related outcomes in patients with obesity: a propensity-matched retrospective cohort study",
"authors": "McCraw CD, Grayeb DR, Gupta N, Zafar P, Javed A, Kainat et al.",
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"kind": "item",
"title": "Heat exposure is associated with a 26% higher risk of death from COPD",
"excerpt": "A meta-analysis of 36 observational studies found heat exposure associated with a 26% higher risk of death from COPD, as compared to 5% for non-fatal illness.",
"url": "https://www.coios.me/heat-exposure-raises-copd-mortality-by-26-and-morbidity-by/",
"published_at": "2026-09-15T21:40:10.000Z",
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"source_url": "https://doi.org/10.1080/09603123.2026.2734444",
"source": "International Journal of Environmental Health Research, 14 September 2026",
"paper_title": "Heat exposure and its impact on COPD morbidity and mortality: a systematic review and meta-analysis",
"authors": "Kim Y, Park H, Lee W",
"doi": "10.1080/09603123.2026.2734444",
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"design": "Systematic review and three-level random-effects meta-analysis of 36 observational studies of heat exposure and COPD outcomes",
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"kind": "item",
"title": "Reanalysed mammography trials are compatible with breast cancer overdiagnosis below 5%",
"excerpt": "A reanalysis of randomised mammography trials, benchmarked against Denmark's Funen screening programme, found the extra cancers detected compatible with breast cancer overdiagnosis below 5%, against published estimates up to 50%.",
"url": "https://www.coios.me/reanalysed-mammography-trials-are-compatible-with/",
"published_at": "2026-09-15T21:39:59.000Z",
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"domain": "Health today",
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"source_url": "https://doi.org/10.1093/jnci/djag302",
"source": "JNCI: Journal of the National Cancer Institute, 14 September 2026",
"paper_title": "Breast cancer overdiagnosis in mammography trials-separating signal from noise: a meta-analysis",
"authors": "Njor SH, Pedersen CU, Lynge E, Smith RA, Rebolj M",
"doi": "10.1093/jnci/djag302",
"type": "Peer-reviewed article",
"design": "Unified reference-based reanalysis and meta-analysis of randomised mammography screening trials, 73 observed relative proportions across 52 follow-up timepoints, benchmarked against the Funen, Denmark service-screening programme",
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"kind": "item",
"title": "Canada's 2025/26 influenza vaccine cut A(H3N2) illness by 38%",
"excerpt": "In Canada's sentinel outpatient network, the 2025/26 vaccine cut the risk of A(H3N2) illness by 38%, even though most circulating viruses differed from the vaccine strain in laboratory tests.",
"url": "https://www.coios.me/canada-s-2025-26-flu-vaccine-cut-a-h3n2-subclade-k-illness/",
"published_at": "2026-09-14T18:00:33.000Z",
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"source_type": "preprint",
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"source_url": "https://doi.org/10.64898/2026.09.10.26362769",
"source": "medRxiv, 12 September 2026",
"paper_title": "2025/26 subclade-specific influenza A and B vaccine effectiveness estimates and discordant laboratory-based indicators of vaccine match or mismatch",
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"title": "Austrian registry data show vaccinated adults died less from causes vaccines cannot affect",
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"source_url": "https://doi.org/10.64898/2026.09.04.26362245",
"source": "medRxiv, 11 September 2026",
"paper_title": "Healthy vaccinee effect in SARS-CoV-2 vaccinees without documented infection",
"authors": "Riedmann U, Brenner H, Ioannidis JP, Pilz S",
"doi": "10.64898/2026.09.04.26362245",
"type": "Preprint",
"design": "National retrospective cohort of 7,416,077 Austrian adults without documented prior infection, registry-linked, 2021 to August 2022, Cox regression plus day-of-vaccination matching",
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"title": "Deaths mentioning lung metastases reached their highest recorded US rate in 2024",
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"url": "https://www.coios.me/mortality-from-secondary-lung-cancer-rose-17-5-above-2000/",
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"verdict": "new",
"source_url": "https://doi.org/10.21203/rs.3.rs-10863252/v1",
"source": "Research Square, 10 September 2026",
"paper_title": "Trends and disparities in mortality involving secondary malignant neoplasm of the lung in the United States, 1999–2024: a serial cross-sectional multiple-cause-of-death analysis",
"authors": "Atif K, Das V, Atif E, Ahmed A, Mazhar MA, Qazi S et al.",
"doi": "10.21203/rs.3.rs-10863252/v1",
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"design": "Serial cross-sectional analysis of CDC WONDER multiple-cause-of-death data, US adults aged ≥25 years, 1999–2024 (n=523,763 deaths with C78.0 code)",
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"kind": "item",
"title": "Healthy working life at 50 averages 11 years across 28 countries",
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"url": "https://www.coios.me/healthy-working-life-expectancy-at-50-averaged-11-years/",
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"eu",
"us",
"gb",
"kr",
"jp",
"mx"
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"source_type": "peer-reviewed",
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"source_url": "https://doi.org/10.1371/journal.pmed.1004676",
"source": "PLOS Medicine, 10 September 2026",
"paper_title": "Country- and individual-level factors associated with healthy working life expectancy: A multinational longitudinal study",
"authors": "Zhu J, Ye B, Huang Z, You H, Jiang J, Yang S et al.",
"doi": "10.1371/journal.pmed.1004676",
"type": "Peer-reviewed article",
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{
"kind": "item",
"title": "Mortality long after Texas cyclones is raised only in socially vulnerable counties",
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"url": "https://www.coios.me/long-run-mortality-from-tropical-cyclones-concentrates-in/",
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"source_url": "https://doi.org/10.21203/rs.3.rs-10831452/v1",
"source": "Research Square, 10 September 2026",
"paper_title": "Social Vulnerability and Long-Run Tropical Cyclone Mortality: Evidence from Texas",
"authors": "Tutay GT, Hasenbein JJ, Kutanoglu E",
"doi": "10.21203/rs.3.rs-10831452/v1",
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"kind": "item",
"title": "Adults with more social ties have slightly lower inflammation across 50 studies",
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"url": "https://www.coios.me/social-role-participation-shows-dose-response-association/",
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"source_url": "https://doi.org/10.1016/j.neubiorev.2026.106962",
"source": "Neuroscience & Biobehavioral Reviews, 9 September 2026",
"paper_title": "Social role participation and inflammation: A meta-analytic examination of the shape of association and variability with age",
"authors": "Hillmann AR, Lam PH, Forest AL, Depro JM, Zou H, Marsland AL et al.",
"doi": "10.1016/j.neubiorev.2026.106962",
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"kind": "item",
"title": "Chronic loneliness is associated with worse health and functioning in older adults",
"excerpt": "Among 4,090 older adults in the English Longitudinal Study of Ageing, persistent loneliness was associated with worse general health, functional capacity and mental wellbeing, and with more unhealthy behaviours.",
"url": "https://www.coios.me/chronic-loneliness-associates-with-worse-health-and/",
"published_at": "2026-09-11T16:52:59.000Z",
"updated_at": "2026-10-18T12:17:08.000Z",
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"source_type": "preprint",
"verdict": "refines",
"source_url": "https://doi.org/10.64898/2026.09.08.26362430",
"source": "medRxiv, 9 September 2026",
"paper_title": "Chronic loneliness and isolation phenotypes and physical and mental health in older adults",
"authors": "Ma Y, Bone JK, Mayston R, Gao Q",
"doi": "10.64898/2026.09.08.26362430",
"type": "Preprint",
"design": "Longitudinal panel study, n=4,090, English Longitudinal Study of Ageing",
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"kind": "item",
"title": "Home-based care use varies across Japanese municipalities despite universal insurance",
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"url": "https://www.coios.me/home-based-care-use-varies-across-japan-s-municipalities/",
"published_at": "2026-09-11T16:52:50.000Z",
"updated_at": "2026-10-18T12:17:08.000Z",
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"source_url": "https://doi.org/10.1186/s44263-026-00314-6",
"source": "BMC Global and Public Health, 10 September 2026",
"paper_title": "Geographic variation and factors associated with home-based long-term care utilization across municipalities in Japan",
"authors": "Sakamoto JL",
"doi": "10.1186/s44263-026-00314-6",
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"kind": "item",
"title": "Genetic score adds little to age and sex in predicting osteoporosis in Japan",
"excerpt": "In 8,711 Japanese adults, a bone density genetic score added little to age and sex, though the lowest-scoring fifth had 1.42 times the osteoporosis incidence of the middle fifth.",
"url": "https://www.coios.me/polygenic-score-for-osteoporosis-shows-modest/",
"published_at": "2026-09-11T16:52:39.000Z",
"updated_at": "2026-10-18T12:17:08.000Z",
"domain": "Health today",
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"What linked data reveals"
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"verdict": "refines",
"source_url": "https://doi.org/10.1038/s10038-026-01498-3",
"source": "Journal of Human Genetics, 9 September 2026",
"paper_title": "Osteoporosis genetic risk prediction using bone mineral density polygenic scores in Japanese: TMM CommCohort study",
"authors": "Otsuka-Yamasaki Y, Sutoh Y, Hachiya T, Nakao M, Minabe S, Komaki S et al.",
"doi": "10.1038/s10038-026-01498-3",
"type": "Peer-reviewed article",
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"kind": "item",
"title": "Review sets out why bone is lost during weight loss",
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"url": "https://www.coios.me/weight-loss-drives-bone-loss-through-endocrine-nutritional/",
"published_at": "2026-09-11T16:52:19.000Z",
"updated_at": "2026-10-18T12:17:08.000Z",
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"source_url": "https://doi.org/10.1007/s11914-026-00984-z",
"source": "Current Osteoporosis Reports, 9 September 2026",
"paper_title": "Why Do We Lose Bone During Weight Loss: Can It Be Prevented?",
"authors": "Shapses SA, McGuire BD",
"doi": "10.1007/s11914-026-00984-z",
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"kind": "item",
"title": "Coinfection with respiratory viruses did not worsen COVID-19 in hospitalised children",
"excerpt": "Among 938 children admitted at Canadian centres that tested every respiratory admission, 18.6% had a viral coinfection, which carried no higher odds of severe COVID-19.",
"url": "https://www.coios.me/sars-cov-2-respiratory-coinfections-not-linked-to-worse-covi/",
"published_at": "2026-09-11T00:48:53.000Z",
"updated_at": "2026-10-18T12:17:08.000Z",
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"countries": [
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"source_url": "https://doi.org/10.1097/inf.0000000000005396",
"source": "Pediatric Infectious Disease Journal, 10 September 2026",
"paper_title": "SARS-CoV-2 Coinfections and Severity in Hospitalized Children With Systematic Testing",
"authors": "Di Chiara C, Farrar DS, Bettinger JA, Campigotto A, Drouin O, Embree J et al.",
"doi": "10.1097/inf.0000000000005396",
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